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Modeling heme pathogenicity and pathway dysregulation in the context of hemolytic disorders

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HemeKG

Assembling and modeling the knowledge around heme pathogenicity and pathway dysregulation in the context of hemolytic disorders. The data hosted in this repo was curated by Farah Humayun in context of her Master's Thesis. The curated documents are located in the hemekg directory.

Citation

If you find HemeKG useful in your work, please consider citing:

[1]Humayun, F., et al. (2020). A computational approach for mapping heme biology in the context of hemolytic disorders. Front. Bioeng. Biotechnol. 8:74.

Installation

The hemekg python package can be installed from PyPI with the following code in your shell:

$ pip install hemekg

The development version can be installed from GitHub with:

$ git clone https://github.com/hemekg/hemekg.git
$ cd hemekg
$ pip install -e .

Commands

To see all the commands, simply run:

$ hemekg

Usage

To get the BEL graph, use the following code:

>>> import hemekg
>>> graph = hemekg.get_graph()
>>> graph.summarize()

Annotations

Auxiliary annotations are located in the hemekg/annotations directory. These include:

  1. TimePoint.
  2. Species.
  3. Concentration.

More BEL Content

See A Listing of Publicly Available Content in the Biological Expression Language (BEL) on Charles Tapley Hoyt's blog for more BEL content.