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CoSMoS_Analysis is software written to analyze image data from CoSMoS (co-localization single-molecule spectroscopy) data. The general approach used is that described in Friedman, L. J.; Gelles, J. "Multi-wavelength single-molecule fluorescence analysis of transcription mechanisms." Methods 2015, 86:27–36 DOI: 10.1016/j.ymeth.2015.05.026.

Important caution: This is a preliminary version of the software. Documentation (see /imscroll/documentation/CoSMoS_Imscroll_instructions.docx in the repository) is basic and the user interface is not fully self-explanatory. Therefore, the software in its present state is of most value to individuals who have already been trained by someone expert in its use.

No support: We think that the CoSMoS image analysis approach implemented in the software is useful, and we would very much like to encourage its use by other investigators. Clearly, doing that will require preparing more documentation, implementing mechanisms to train new users and providing ways for users to have input into future development. Unfortunately, we simply do not have at present the funding to do any of those things. Therefore, we are currently unable to provide support for the software.

License: In order to allow it to be easily used by other researchers, this software is open-source software licensed under the GNU General Public License (GPL), version 3. The license does impose some restrictions; please read the license for details.

Author: Larry J. Friedman; Department of Biochemistry, MS009; Brandeis University; PO Box 549110; Waltham, MA 02454-9110; larryfj@brandeis.edu

Acknowledgements: Some parts of CoSMoS_Analysis development were funded by grants from NIGMS.

Citation: If you publish research that uses this software and need a literature citation for your Methods section, you can cite the Methods article mentioned above and/or https://github.com/gelles-brandeis/CoSMoS_Analysis