diff --git a/packages/integrations/useAxios/index.test.ts b/packages/integrations/useAxios/index.test.ts
index 9054f6d69a8..b069b4ab736 100644
--- a/packages/integrations/useAxios/index.test.ts
+++ b/packages/integrations/useAxios/index.test.ts
@@ -210,4 +210,42 @@ describe('useAxios', () => {
       expect(onRejected).toBeCalledTimes(0)
     }, onRejected)
   })
+
+  test('use generic type', async () => {
+    interface ReqType {
+      title: string
+      body: string
+      userId: number
+    }
+
+    interface ResType {
+      id: number
+      title: string
+      body: string
+      userId: number
+    }
+    const typeConfig: AxiosRequestConfig<ReqType> = {
+      method: 'POST',
+    }
+    const { isLoading, then, execute } = useAxios<ResType, ReqType>('/posts', typeConfig, instance, options)
+    expect(isLoading.value).toBeFalsy()
+    const requestData: ReqType = {
+      title: 'title',
+      body: 'body',
+      userId: 123,
+    }
+    execute({ data: requestData })
+    expect(isLoading.value).toBeTruthy()
+    const onRejected = vitest.fn()
+
+    await then((result) => {
+      expect(result.data).toBeDefined()
+      expect(result.data.value?.title).toBe('title')
+      expect(result.data.value?.body).toBe('body')
+      expect(result.data.value?.userId).toBe(123)
+      expect(result.data.value?.id).toBeDefined()
+      expect(isLoading.value).toBeFalsy()
+      expect(onRejected).toBeCalledTimes(0)
+    }, onRejected)
+  })
 })
diff --git a/packages/integrations/useAxios/index.ts b/packages/integrations/useAxios/index.ts
index 057b47108f4..905e538ae74 100644
--- a/packages/integrations/useAxios/index.ts
+++ b/packages/integrations/useAxios/index.ts
@@ -4,11 +4,11 @@ import { isString, until } from '@vueuse/shared'
 import type { AxiosError, AxiosInstance, AxiosRequestConfig, AxiosResponse, CancelTokenSource } from 'axios'
 import axios from 'axios'
 
-export interface UseAxiosReturn<T> {
+export interface UseAxiosReturn<T, D> {
   /**
    * Axios Response
    */
-  response: ShallowRef<AxiosResponse<T> | undefined>
+  response: ShallowRef<AxiosResponse<T, D> | undefined>
 
   /**
    * Axios response data
@@ -74,17 +74,17 @@ export interface UseAxiosReturn<T> {
    */
   isCanceled: Ref<boolean>
 }
-export interface StrictUseAxiosReturn<T> extends UseAxiosReturn<T> {
+export interface StrictUseAxiosReturn<T, D> extends UseAxiosReturn<T, D> {
   /**
    * Manually call the axios request
    */
-  execute: (url?: string | AxiosRequestConfig, config?: AxiosRequestConfig) => PromiseLike<StrictUseAxiosReturn<T>>
+  execute: (url?: string | AxiosRequestConfig<D>, config?: AxiosRequestConfig<D>) => PromiseLike<StrictUseAxiosReturn<T, D>>
 }
-export interface EasyUseAxiosReturn<T> extends UseAxiosReturn<T> {
+export interface EasyUseAxiosReturn<T, D> extends UseAxiosReturn<T, D> {
   /**
    * Manually call the axios request
    */
-  execute: (url: string, config?: AxiosRequestConfig) => PromiseLike<EasyUseAxiosReturn<T>>
+  execute: (url: string, config?: AxiosRequestConfig<D>) => PromiseLike<EasyUseAxiosReturn<T, D>>
 }
 export interface UseAxiosOptions {
   /**
@@ -93,24 +93,24 @@ export interface UseAxiosOptions {
    */
   immediate?: boolean
 }
-type OverallUseAxiosReturn<T> = StrictUseAxiosReturn<T> | EasyUseAxiosReturn<T>
+type OverallUseAxiosReturn<T, D> = StrictUseAxiosReturn<T, D> | EasyUseAxiosReturn<T, D>
 
-export function useAxios<T = any>(url: string, config?: AxiosRequestConfig, options?: UseAxiosOptions): StrictUseAxiosReturn<T> & PromiseLike<StrictUseAxiosReturn<T>>
-export function useAxios<T = any>(url: string, instance?: AxiosInstance, options?: UseAxiosOptions): StrictUseAxiosReturn<T> & PromiseLike<StrictUseAxiosReturn<T>>
-export function useAxios<T = any>(url: string, config: AxiosRequestConfig, instance: AxiosInstance, options?: UseAxiosOptions): StrictUseAxiosReturn<T> & PromiseLike<StrictUseAxiosReturn<T>>
-export function useAxios<T = any>(config?: AxiosRequestConfig): EasyUseAxiosReturn<T> & PromiseLike<EasyUseAxiosReturn<T>>
-export function useAxios<T = any>(instance?: AxiosInstance): EasyUseAxiosReturn<T> & PromiseLike<EasyUseAxiosReturn<T>>
-export function useAxios<T = any>(config?: AxiosRequestConfig, instance?: AxiosInstance): EasyUseAxiosReturn<T> & PromiseLike<EasyUseAxiosReturn<T>>
+export function useAxios<T = any, D = any>(url: string, config?: AxiosRequestConfig<D>, options?: UseAxiosOptions): StrictUseAxiosReturn<T, D> & PromiseLike<StrictUseAxiosReturn<T, D>>
+export function useAxios<T = any, D = any>(url: string, instance?: AxiosInstance, options?: UseAxiosOptions): StrictUseAxiosReturn<T, D> & PromiseLike<StrictUseAxiosReturn<T, D>>
+export function useAxios<T = any, D = any>(url: string, config: AxiosRequestConfig<D>, instance: AxiosInstance, options?: UseAxiosOptions): StrictUseAxiosReturn<T, D> & PromiseLike<StrictUseAxiosReturn<T, D>>
+export function useAxios<T = any, D = any>(config?: AxiosRequestConfig<D>): EasyUseAxiosReturn<T, D> & PromiseLike<EasyUseAxiosReturn<T, D>>
+export function useAxios<T = any, D = any>(instance?: AxiosInstance): EasyUseAxiosReturn<T, D> & PromiseLike<EasyUseAxiosReturn<T, D>>
+export function useAxios<T = any, D = any>(config?: AxiosRequestConfig<D>, instance?: AxiosInstance): EasyUseAxiosReturn<T, D> & PromiseLike<EasyUseAxiosReturn<T, D>>
 
 /**
  * Wrapper for axios.
  *
  * @see https://vueuse.org/useAxios
  */
-export function useAxios<T = any>(...args: any[]): OverallUseAxiosReturn<T> & PromiseLike<OverallUseAxiosReturn<T>> {
+export function useAxios<T = any, D = any>(...args: any[]): OverallUseAxiosReturn<T, D> & PromiseLike<OverallUseAxiosReturn<T, D>> {
   const url: string | undefined = typeof args[0] === 'string' ? args[0] : undefined
   const argsPlaceholder = isString(url) ? 1 : 0
-  let defaultConfig: AxiosRequestConfig = {}
+  let defaultConfig: AxiosRequestConfig<D> = {}
   let instance: AxiosInstance = axios
   let options: UseAxiosOptions = { immediate: !!argsPlaceholder }
 
@@ -160,15 +160,15 @@ export function useAxios<T = any>(...args: any[]): OverallUseAxiosReturn<T> & Pr
     isFinished.value = !loading
   }
   const waitUntilFinished = () =>
-    new Promise<OverallUseAxiosReturn<T>>((resolve, reject) => {
+    new Promise<OverallUseAxiosReturn<T, D>>((resolve, reject) => {
       until(isFinished).toBe(true)
         // eslint-disable-next-line @typescript-eslint/no-use-before-define
         .then(() => resolve(result))
         .catch(reject)
     })
-  const then: PromiseLike<OverallUseAxiosReturn<T>>['then'] = (onFulfilled, onRejected) =>
+  const then: PromiseLike<OverallUseAxiosReturn<T, D>>['then'] = (onFulfilled, onRejected) =>
     waitUntilFinished().then(onFulfilled, onRejected)
-  const execute: OverallUseAxiosReturn<T>['execute'] = (executeUrl: string | AxiosRequestConfig | undefined = url, config: AxiosRequestConfig = {}) => {
+  const execute: OverallUseAxiosReturn<T, D>['execute'] = (executeUrl: string | AxiosRequestConfig<D> | undefined = url, config: AxiosRequestConfig<D> = {}) => {
     error.value = undefined
     const _url = typeof executeUrl === 'string'
       ? executeUrl
@@ -186,7 +186,7 @@ export function useAxios<T = any>(...args: any[]): OverallUseAxiosReturn<T> & Pr
     return { then }
   }
   if (options.immediate && url)
-    (execute as StrictUseAxiosReturn<T>['execute'])()
+    (execute as StrictUseAxiosReturn<T, D>['execute'])()
 
   const result = {
     response,
@@ -203,7 +203,7 @@ export function useAxios<T = any>(...args: any[]): OverallUseAxiosReturn<T> & Pr
     isCanceled: isAborted,
     abort,
     execute,
-  } as OverallUseAxiosReturn<T>
+  } as OverallUseAxiosReturn<T, D>
 
   return {
     ...result,