diff --git a/packages/compiler-sfc/src/compileScript.ts b/packages/compiler-sfc/src/compileScript.ts
index d6e066d8066..719b53592d0 100644
--- a/packages/compiler-sfc/src/compileScript.ts
+++ b/packages/compiler-sfc/src/compileScript.ts
@@ -910,11 +910,11 @@ export function compileScript(
             } else {
               let start = decl.start! + startOffset
               let end = decl.end! + startOffset
-              if (i < total - 1) {
-                // not the last one, locate the start of the next
+              if (i === 0) {
+                // first one, locate the start of the next
                 end = node.declarations[i + 1].start! + startOffset
               } else {
-                // last one, locate the end of the prev
+                // not first one, locate the end of the prev
                 start = node.declarations[i - 1].end! + startOffset
               }
               s.remove(start, end)
diff --git a/packages/compiler-sfc/test/__snapshots__/compileScript.spec.ts.snap b/packages/compiler-sfc/test/__snapshots__/compileScript.spec.ts.snap
index bcecdb4efb5..594c909ee39 100644
--- a/packages/compiler-sfc/test/__snapshots__/compileScript.spec.ts.snap
+++ b/packages/compiler-sfc/test/__snapshots__/compileScript.spec.ts.snap
@@ -288,6 +288,22 @@ return { props, a, emit }
 }"
 `;
 
+exports[`SFC compile <script setup> > defineProps/defineEmits in multi-variable declaration fix #6757  1`] = `
+"export default {
+  props: ['item'],
+  emits: ['a'],
+  setup(__props, { emit }) {
+
+const props = __props
+
+    const a = 1;
+    
+return { a, props, emit }
+}
+
+}"
+`;
+
 exports[`SFC compile <script setup> > dev mode import usage check > TS annotations 1`] = `
 "import { defineComponent as _defineComponent } from 'vue'
 import { Foo, Baz, Qux, Fred } from './x'
diff --git a/packages/compiler-sfc/test/compileScript.spec.ts b/packages/compiler-sfc/test/compileScript.spec.ts
index 854178c39ed..b00ab82975c 100644
--- a/packages/compiler-sfc/test/compileScript.spec.ts
+++ b/packages/compiler-sfc/test/compileScript.spec.ts
@@ -141,6 +141,21 @@ const myEmit = defineEmits(['foo', 'bar'])
     expect(content).toMatch(`emits: ['a'],`)
   })
 
+  // vuejs/core #6757
+  test('defineProps/defineEmits in multi-variable declaration fix #6757 ', () => {
+    const { content } = compile(`
+    <script setup>
+    const a = 1,
+          props = defineProps(['item']),
+          emit = defineEmits(['a']);
+    </script>
+  `)
+    assertCode(content)
+    expect(content).toMatch(`const a = 1;`) // test correct removal
+    expect(content).toMatch(`props: ['item'],`)
+    expect(content).toMatch(`emits: ['a'],`)
+  })
+
   test('defineProps/defineEmits in multi-variable declaration (full removal)', () => {
     const { content } = compile(`
     <script setup>