diff --git a/packages/vite/src/node/__tests__/plugins/import.spec.ts b/packages/vite/src/node/__tests__/plugins/import.spec.ts
index fb9ae3b132325c..38349ad2f59274 100644
--- a/packages/vite/src/node/__tests__/plugins/import.spec.ts
+++ b/packages/vite/src/node/__tests__/plugins/import.spec.ts
@@ -44,7 +44,7 @@ describe('transformCjsImport', () => {
       ),
     ).toBe(
       'import __vite__cjsImport0_react from "./node_modules/.vite/deps/react.js"; ' +
-        'const React = __vite__cjsImport0_react.__esModule ? __vite__cjsImport0_react.default : __vite__cjsImport0_react',
+        'const React = __vite__cjsImport0_react.__esModule && Object.prototype.hasOwnProperty.call(__vite__cjsImport0_react, "default") ? __vite__cjsImport0_react.default : __vite__cjsImport0_react',
     )
 
     expect(
@@ -58,7 +58,7 @@ describe('transformCjsImport', () => {
       ),
     ).toBe(
       'import __vite__cjsImport0_react from "./node_modules/.vite/deps/react.js"; ' +
-        'const React = __vite__cjsImport0_react.__esModule ? __vite__cjsImport0_react.default : __vite__cjsImport0_react',
+        'const React = __vite__cjsImport0_react.__esModule && Object.prototype.hasOwnProperty.call(__vite__cjsImport0_react, "default") ? __vite__cjsImport0_react.default : __vite__cjsImport0_react',
     )
   })
 
@@ -74,7 +74,7 @@ describe('transformCjsImport', () => {
       ),
     ).toBe(
       'import __vite__cjsImport0_react from "./node_modules/.vite/deps/react.js"; ' +
-        `const react = ((m) => m?.__esModule ? m : { ...typeof m === "object" && !Array.isArray(m) || typeof m === "function" ? m : {}, default: m })(__vite__cjsImport0_react)`,
+        `const react = ((m) => m?.__esModule && Object.prototype.hasOwnProperty.call(m, "default") ? m : { ...typeof m === "object" && !Array.isArray(m) || typeof m === "function" ? m : {}, default: m })(__vite__cjsImport0_react)`,
     )
   })
 
@@ -154,7 +154,7 @@ describe('transformCjsImport', () => {
       ),
     ).toBe(
       'import __vite__cjsImport0_react from "./node_modules/.vite/deps/react.js"; ' +
-        'const __vite__cjsExportDefault_0 = __vite__cjsImport0_react.__esModule ? __vite__cjsImport0_react.default : __vite__cjsImport0_react; ' +
+        'const __vite__cjsExportDefault_0 = __vite__cjsImport0_react.__esModule && Object.prototype.hasOwnProperty.call(__vite__cjsImport0_react, "default") ? __vite__cjsImport0_react.default : __vite__cjsImport0_react; ' +
         'export default __vite__cjsExportDefault_0',
     )
 
@@ -169,7 +169,7 @@ describe('transformCjsImport', () => {
       ),
     ).toBe(
       'import __vite__cjsImport0_react from "./node_modules/.vite/deps/react.js"; ' +
-        'const __vite__cjsExport_React = __vite__cjsImport0_react.__esModule ? __vite__cjsImport0_react.default : __vite__cjsImport0_react; ' +
+        'const __vite__cjsExport_React = __vite__cjsImport0_react.__esModule && Object.prototype.hasOwnProperty.call(__vite__cjsImport0_react, "default") ? __vite__cjsImport0_react.default : __vite__cjsImport0_react; ' +
         'export { __vite__cjsExport_React as React }',
     )
 
diff --git a/packages/vite/src/node/plugins/importAnalysis.ts b/packages/vite/src/node/plugins/importAnalysis.ts
index a4c1b9fd38a033..99b630823ae84c 100644
--- a/packages/vite/src/node/plugins/importAnalysis.ts
+++ b/packages/vite/src/node/plugins/importAnalysis.ts
@@ -845,7 +845,7 @@ export function createParseErrorInfo(
   }
 }
 // prettier-ignore
-const interopHelper = (m: any) => m?.__esModule ? m : { ...(typeof m === 'object' && !Array.isArray(m) || typeof m === 'function' ? m : {}), default: m }
+const interopHelper = (m: any) => m?.__esModule && Object.prototype.hasOwnProperty.call(m, 'default') ? m : { ...(typeof m === 'object' && !Array.isArray(m) || typeof m === 'function' ? m : {}), default: m }
 
 export function interopNamedImports(
   str: MagicString,
@@ -1010,7 +1010,7 @@ export function transformCjsImport(
         )
       } else if (importedName === 'default') {
         lines.push(
-          `const ${localName} = ${cjsModuleName}.__esModule ? ${cjsModuleName}.default : ${cjsModuleName}`,
+          `const ${localName} = ${cjsModuleName}.__esModule && Object.prototype.hasOwnProperty.call(${cjsModuleName}, "default") ? ${cjsModuleName}.default : ${cjsModuleName}`,
         )
       } else {
         lines.push(`const ${localName} = ${cjsModuleName}["${importedName}"]`)
diff --git a/playground/optimize-deps/cjs-dynamic.js b/playground/optimize-deps/cjs-dynamic.js
index b75e4c2d0ba118..aa2585cc1b3647 100644
--- a/playground/optimize-deps/cjs-dynamic.js
+++ b/playground/optimize-deps/cjs-dynamic.js
@@ -28,6 +28,15 @@
     text('.cjs-dynamic-dep-cjs-compiled-from-cjs', 'ok')
   }
 
+  const cjsWithEsModuleTag = await import(
+    '@vitejs/test-dep-cjs-with-es-module-flag'
+  )
+  console.log('cjsWithEsModuleTag', cjsWithEsModuleTag)
+  text(
+    '.cjs-dynamic-dep-cjs-with-es-module-flag',
+    cjsWithEsModuleTag.default.info,
+  )
+
   function App() {
     const [count, setCount] = useState(0)
 
diff --git a/playground/optimize-deps/cjs.js b/playground/optimize-deps/cjs.js
index ba3e0aa783e69c..5d24ac52affe6e 100644
--- a/playground/optimize-deps/cjs.js
+++ b/playground/optimize-deps/cjs.js
@@ -5,7 +5,7 @@ import React, { useState } from 'react'
 import ReactDOM from 'react-dom/client'
 import { Socket } from 'phoenix'
 import clip from 'clipboard'
-
+import m from '@vitejs/test-dep-cjs-with-es-module-flag'
 // Test exporting a name that was already imported
 export { useState } from 'react'
 export { useState as anotherNameForUseState } from 'react'
@@ -19,6 +19,8 @@ if (typeof Socket === 'function') {
   text('.cjs-phoenix', 'ok')
 }
 
+text('.cjs-with-es-module-flag', m.info)
+
 function App() {
   const [count, setCount] = useState(0)
 
diff --git a/playground/optimize-deps/dep-cjs-with-es-module-flag/index.js b/playground/optimize-deps/dep-cjs-with-es-module-flag/index.js
new file mode 100644
index 00000000000000..4b006a74d82270
--- /dev/null
+++ b/playground/optimize-deps/dep-cjs-with-es-module-flag/index.js
@@ -0,0 +1,4 @@
+module.exports = {
+  __esModule: true,
+  info: 'ok',
+}
diff --git a/playground/optimize-deps/dep-cjs-with-es-module-flag/package.json b/playground/optimize-deps/dep-cjs-with-es-module-flag/package.json
new file mode 100644
index 00000000000000..d17358e7152afe
--- /dev/null
+++ b/playground/optimize-deps/dep-cjs-with-es-module-flag/package.json
@@ -0,0 +1,5 @@
+{
+  "name": "@vitejs/test-dep-cjs-with-es-module-flag",
+  "version": "1.0.0",
+  "main": "index.js"
+}
diff --git a/playground/optimize-deps/index.html b/playground/optimize-deps/index.html
index 9b992b7dd4892a..01bf85354694fc 100644
--- a/playground/optimize-deps/index.html
+++ b/playground/optimize-deps/index.html
@@ -6,6 +6,8 @@ <h2>CommonJS w/ named imports (phoenix)</h2>
 <div class="cjs-phoenix">fail</div>
 <h2>CommonJS w/ default export (clipboard)</h2>
 <div class="cjs-clipboard">fail</div>
+<h2>CommonJS w/ default export (dep-cjs-with-es-module-flag)</h2>
+<div class="cjs-with-es-module-flag">fail</div>
 
 <script type="module" src="./cjs.js"></script>
 
@@ -19,6 +21,8 @@ <h2>CommonJS dynamic import default (dep-cjs-compiled-from-esm)</h2>
 <div class="cjs-dynamic-dep-cjs-compiled-from-esm"></div>
 <h2>CommonJS dynamic import default (dep-cjs-compiled-from-cjs)</h2>
 <div class="cjs-dynamic-dep-cjs-compiled-from-cjs"></div>
+<h2>CommonJS dynamic import default (dep-cjs-with-es-module-flag)</h2>
+<div class="cjs-dynamic-dep-cjs-with-es-module-flag"></div>
 
 <script type="module" src="./cjs-dynamic.js"></script>
 
diff --git a/playground/optimize-deps/package.json b/playground/optimize-deps/package.json
index e5f8d8a22dfcef..967e7bd8ecb93d 100644
--- a/playground/optimize-deps/package.json
+++ b/playground/optimize-deps/package.json
@@ -36,6 +36,7 @@
     "@vitejs/test-dep-with-optional-peer-dep-submodule": "file:./dep-with-optional-peer-dep-submodule",
     "@vitejs/test-dep-non-optimized": "file:./dep-non-optimized",
     "@vitejs/test-added-in-entries": "file:./added-in-entries",
+    "@vitejs/test-dep-cjs-with-es-module-flag": "file:./dep-cjs-with-es-module-flag",
     "lodash-es": "^4.17.21",
     "@vitejs/test-nested-exclude": "file:./nested-exclude",
     "phoenix": "^1.7.11",
diff --git a/playground/optimize-deps/vite.config.js b/playground/optimize-deps/vite.config.js
index a2c2fdf3c6d5e7..c717db43324e32 100644
--- a/playground/optimize-deps/vite.config.js
+++ b/playground/optimize-deps/vite.config.js
@@ -22,6 +22,7 @@ export default defineConfig({
       '@vitejs/test-dep-optimize-exports-with-glob/**/*',
       '@vitejs/test-dep-optimize-exports-with-root-glob/**/*.js',
       '@vitejs/test-dep-optimize-with-glob/**/*.js',
+      '@vitejs/test-dep-cjs-with-es-module-flag',
     ],
     exclude: ['@vitejs/test-nested-exclude', '@vitejs/test-dep-non-optimized'],
     esbuildOptions: {
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 603da0897e4f80..d90ce26caca168 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -906,6 +906,9 @@ importers:
       '@vitejs/test-dep-cjs-with-assets':
         specifier: file:./dep-cjs-with-assets
         version: file:playground/optimize-deps/dep-cjs-with-assets
+      '@vitejs/test-dep-cjs-with-es-module-flag':
+        specifier: file:./dep-cjs-with-es-module-flag
+        version: file:playground/optimize-deps/dep-cjs-with-es-module-flag
       '@vitejs/test-dep-css-require':
         specifier: file:./dep-css-require
         version: file:playground/optimize-deps/dep-css-require
@@ -1027,6 +1030,8 @@ importers:
 
   playground/optimize-deps/dep-cjs-with-assets: {}
 
+  playground/optimize-deps/dep-cjs-with-es-module-flag: {}
+
   playground/optimize-deps/dep-css-require: {}
 
   playground/optimize-deps/dep-esbuild-plugin-transform: {}
@@ -10572,6 +10577,11 @@ packages:
     name: '@vitejs/test-dep-cjs-with-assets'
     dev: false
 
+  file:playground/optimize-deps/dep-cjs-with-es-module-flag:
+    resolution: {directory: playground/optimize-deps/dep-cjs-with-es-module-flag, type: directory}
+    name: '@vitejs/test-dep-cjs-with-es-module-flag'
+    dev: false
+
   file:playground/optimize-deps/dep-css-require:
     resolution: {directory: playground/optimize-deps/dep-css-require, type: directory}
     name: '@vitejs/test-dep-css-require'