diff --git a/package.json b/package.json
index a364f9fa38b3..af8fd7315dd9 100644
--- a/package.json
+++ b/package.json
@@ -64,6 +64,7 @@
     "@types/selenium-webdriver": "4.0.15",
     "@types/sharp": "0.29.3",
     "@types/string-hash": "1.1.1",
+    "@types/trusted-types": "2.0.2",
     "@typescript-eslint/eslint-plugin": "4.29.1",
     "@typescript-eslint/parser": "4.29.1",
     "@vercel/fetch": "6.1.1",
diff --git a/packages/next/client/route-loader.ts b/packages/next/client/route-loader.ts
index d1198fc2a024..56d0a0200ba8 100644
--- a/packages/next/client/route-loader.ts
+++ b/packages/next/client/route-loader.ts
@@ -1,5 +1,6 @@
 import type { ComponentType } from 'react'
 import getAssetPathFromRoute from '../shared/lib/router/utils/get-asset-path-from-route'
+import { __unsafeCreateTrustedScriptURL } from './trusted-types'
 import { requestIdleCallback } from './request-idle-callback'
 
 // 3.8s was arbitrarily chosen as it's what https://web.dev/interactive
@@ -135,7 +136,7 @@ export function isAssetError(err?: Error): boolean | undefined {
 }
 
 function appendScript(
-  src: string,
+  src: TrustedScriptURL | string,
   script?: HTMLScriptElement
 ): Promise<unknown> {
   return new Promise((resolve, reject) => {
@@ -154,7 +155,7 @@ function appendScript(
 
     // 3. Finally, set the source and inject into the DOM in case the child
     //    must be appended for fetching to start.
-    script.src = src
+    script.src = src as string
     document.body.appendChild(script)
   })
 }
@@ -254,7 +255,7 @@ export function getMiddlewareManifest() {
 }
 
 interface RouteFiles {
-  scripts: string[]
+  scripts: (TrustedScriptURL | string)[]
   css: string[]
 }
 function getFilesForRoute(
@@ -262,12 +263,12 @@ function getFilesForRoute(
   route: string
 ): Promise<RouteFiles> {
   if (process.env.NODE_ENV === 'development') {
+    const scriptUrl =
+      assetPrefix +
+      '/_next/static/chunks/pages' +
+      encodeURI(getAssetPathFromRoute(route, '.js'))
     return Promise.resolve({
-      scripts: [
-        assetPrefix +
-          '/_next/static/chunks/pages' +
-          encodeURI(getAssetPathFromRoute(route, '.js')),
-      ],
+      scripts: [__unsafeCreateTrustedScriptURL(scriptUrl)],
       // Styles are handled by `style-loader` in development:
       css: [],
     })
@@ -280,7 +281,9 @@ function getFilesForRoute(
       (entry) => assetPrefix + '/_next/' + encodeURI(entry)
     )
     return {
-      scripts: allFiles.filter((v) => v.endsWith('.js')),
+      scripts: allFiles
+        .filter((v) => v.endsWith('.js'))
+        .map((v) => __unsafeCreateTrustedScriptURL(v)),
       css: allFiles.filter((v) => v.endsWith('.css')),
     }
   })
@@ -294,12 +297,14 @@ export function createRouteLoader(assetPrefix: string): RouteLoader {
   const routes: Map<string, Future<RouteLoaderEntry> | RouteLoaderEntry> =
     new Map()
 
-  function maybeExecuteScript(src: string): Promise<unknown> {
+  function maybeExecuteScript(
+    src: TrustedScriptURL | string
+  ): Promise<unknown> {
     // With HMR we might need to "reload" scripts when they are
     // disposed and readded. Executing scripts twice has no functional
     // differences
     if (process.env.NODE_ENV !== 'development') {
-      let prom: Promise<unknown> | undefined = loadedScripts.get(src)
+      let prom: Promise<unknown> | undefined = loadedScripts.get(src.toString())
       if (prom) {
         return prom
       }
@@ -309,7 +314,7 @@ export function createRouteLoader(assetPrefix: string): RouteLoader {
         return Promise.resolve()
       }
 
-      loadedScripts.set(src, (prom = appendScript(src)))
+      loadedScripts.set(src.toString(), (prom = appendScript(src)))
       return prom
     } else {
       return appendScript(src)
@@ -432,7 +437,9 @@ export function createRouteLoader(assetPrefix: string): RouteLoader {
         .then((output) =>
           Promise.all(
             canPrefetch
-              ? output.scripts.map((script) => prefetchViaDom(script, 'script'))
+              ? output.scripts.map((script) =>
+                  prefetchViaDom(script.toString(), 'script')
+                )
               : []
           )
         )
diff --git a/packages/next/client/trusted-types.ts b/packages/next/client/trusted-types.ts
new file mode 100644
index 000000000000..9682635eb945
--- /dev/null
+++ b/packages/next/client/trusted-types.ts
@@ -0,0 +1,37 @@
+/**
+ * Stores the Trusted Types Policy. Starts as undefined and can be set to null
+ * if Trusted Types is not supported in the browser.
+ */
+let policy: TrustedTypePolicy | null | undefined
+
+/**
+ * Getter for the Trusted Types Policy. If it is undefined, it is instantiated
+ * here or set to null if Trusted Types is not supported in the browser.
+ */
+function getPolicy() {
+  if (typeof policy === 'undefined' && typeof window !== 'undefined') {
+    policy =
+      window.trustedTypes?.createPolicy('nextjs', {
+        createHTML: (input) => input,
+        createScript: (input) => input,
+        createScriptURL: (input) => input,
+      }) || null
+  }
+
+  return policy
+}
+
+/**
+ * Unsafely promote a string to a TrustedScriptURL, falling back to strings
+ * when Trusted Types are not available.
+ * This is a security-sensitive function; any use of this function
+ * must go through security review. In particular, it must be assured that the
+ * provided string will never cause an XSS vulnerability if used in a context
+ * that will cause a browser to load and execute a resource, e.g. when
+ * assigning to script.src.
+ */
+export function __unsafeCreateTrustedScriptURL(
+  url: string
+): TrustedScriptURL | string {
+  return getPolicy()?.createScriptURL(url) || url
+}
diff --git a/tsec-exemptions.json b/tsec-exemptions.json
index ec33c3b673ea..acbcecdaa91c 100644
--- a/tsec-exemptions.json
+++ b/tsec-exemptions.json
@@ -9,10 +9,8 @@
     "packages/next/client/script.tsx"
   ],
   "ban-script-content-assignments": ["packages/next/client/script.tsx"],
-  "ban-script-src-assignments": [
-    "packages/next/client/route-loader.ts",
-    "packages/next/client/script.tsx"
-  ],
+  "ban-script-src-assignments": ["packages/next/client/script.tsx"],
+  "ban-trustedtypes-createpolicy": ["packages/next/client/trusted-types.ts"],
   "ban-window-stringfunctiondef": [
     "packages/next/lib/recursive-delete.ts",
     "packages/next/client/dev/fouc.ts"
diff --git a/yarn.lock b/yarn.lock
index f3c7da9ae708..3cae0cb367a2 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -5407,6 +5407,11 @@
   dependencies:
     "@types/node" "*"
 
+"@types/trusted-types@2.0.2":
+  version "2.0.2"
+  resolved "https://registry.yarnpkg.com/@types/trusted-types/-/trusted-types-2.0.2.tgz#fc25ad9943bcac11cceb8168db4f275e0e72e756"
+  integrity sha512-F5DIZ36YVLE+PN+Zwws4kJogq47hNgX3Nx6WyDJ3kcplxyke3XIzB8uK5n/Lpm1HBsbGzd6nmGehL8cPekP+Tg==
+
 "@types/ua-parser-js@0.7.36":
   version "0.7.36"
   resolved "https://registry.yarnpkg.com/@types/ua-parser-js/-/ua-parser-js-0.7.36.tgz#9bd0b47f26b5a3151be21ba4ce9f5fa457c5f190"