diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index 3ae94ac3..0f4cd85d 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -71,14 +71,6 @@ jobs:
           experimental: [false]
 
           include:
-          # Pythons too old for latest
-          - python-version: "3.7"
-            twisted-version: "lowest"
-            experimental: false
-
-          - python-version: "pypy-3.8"
-            twisted-version: "lowest"
-            experimental: false
 
           # Pythons too new for lowest
           - python-version: "3.11"
@@ -119,7 +111,6 @@ jobs:
       shell: python
       run: |
         table = {
-          "3.7": "py37",
           "3.8": "py38",
           "3.9": "py39",
           "3.10": "py310",
diff --git a/changelog.d/378.removal.rst b/changelog.d/378.removal.rst
new file mode 100644
index 00000000..33af59ea
--- /dev/null
+++ b/changelog.d/378.removal.rst
@@ -0,0 +1 @@
+Support for Python 3.7 and PyPy 3.8, which have reached end of support, has been dropped.
diff --git a/tox.ini b/tox.ini
index b22c5db0..c43dcf0b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 envlist =
-    py37-twisted_lowest,
+    py38-twisted_lowest,
     {pypy3,py38,py39,py310,py311,py312}-twisted_latest,
     {pypy3,py38,py39,py310,py311,py312}-twisted_trunk,
     twine, check-manifest, flake8, docs, coverage-report
@@ -72,7 +72,7 @@ commands =
     sphinx-build -b html . html
 
 [testenv:coverage-report]
-depends = pypy3,py37,py38,py39,py310,py311,py312
+depends = pypy3,py38,py39,py310,py311,py312
 commands =
     coverage combine
     coverage report