diff --git a/lib/markdown2.py b/lib/markdown2.py
index 58c1b707..b023fae5 100755
--- a/lib/markdown2.py
+++ b/lib/markdown2.py
@@ -389,12 +389,17 @@ def convert(self, text):
             # return the removed text warning to its markdown.py compatible form
             text = text.replace(self.html_removed_text, self.html_removed_text_compat)
 
-        if "nofollow" in self.extras:
-            text = self._a_nofollow.sub(r'<\1 rel="nofollow"\2', text)
-
         if "target-blank-links" in self.extras:
             text = self._a_blank.sub(r'<\1 target="_blank"\2', text)
 
+        if "nofollow" in self.extras:
+            if "target-blank-links" in self.extras:
+                text = self._a_nofollow.sub(r'<\1 rel="nofollow noopener"\2', text)
+            else:
+                text = self._a_nofollow.sub(r'<\1 rel="nofollow"\2', text)
+        elif "target-blank-links" in self.extras:
+            text = self._a_nofollow.sub(r'<\1 rel="noopener"\2', text)
+
         if "toc" in self.extras and self._toc:
             self._toc_html = calculate_toc_html(self._toc)
 
@@ -2234,7 +2239,7 @@ def _encode_amps_and_angles(self, text):
     def _encode_incomplete_tags(self, text):
         if self.safe_mode not in ("replace", "escape"):
             return text
-            
+
         if text.endswith(">"):
             return text  # this is not an incomplete tag, this is a link in the form <http://x.y.z>
 
diff --git a/test/tm-cases/link_with_blank.html b/test/tm-cases/link_with_blank.html
index 0d6e1dfe..df2c0037 100644
--- a/test/tm-cases/link_with_blank.html
+++ b/test/tm-cases/link_with_blank.html
@@ -1,5 +1,5 @@
-<p><a target="_blank" href="http://www.example.com">Ref</a></p>
+<p><a rel="noopener" target="_blank" href="http://www.example.com">Ref</a></p>
 
 <p><a href="#bar">Foo</a></p>
 
-<p><a target="_blank" href="http://www.example.com/two#three">One</a></p>
+<p><a rel="noopener" target="_blank" href="http://www.example.com/two#three">One</a></p>