diff --git a/CHANGELOG.md b/CHANGELOG.md
index 83e9e0fe63..df11b95e10 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,7 +15,8 @@ We use *breaking :warning:* to mark changes that are not backward compatible (re
 ### Changed
 
 - [#5205](https://github.com/thanos-io/thanos/pull/5205) Rule: Add ruler labels as external labels in stateless ruler mode.
-- [#5206](https://github.com/thanos-io/thanos/pull/5206) Cache: add timeout for groupcache's fetch operation
+- [#5206](https://github.com/thanos-io/thanos/pull/5206) Cache: add timeout for groupcache's fetch operation.
+- [#5218](https://github.com/thanos-io/thanos/pull/5218) Tools: Run bucket downsample tools continuously.
 
 ### Removed
 
diff --git a/cmd/thanos/downsample.go b/cmd/thanos/downsample.go
index 3537028268..bd299c1e3e 100644
--- a/cmd/thanos/downsample.go
+++ b/cmd/thanos/downsample.go
@@ -69,6 +69,7 @@ func RunDownsample(
 	httpTLSConfig string,
 	httpGracePeriod time.Duration,
 	dataDir string,
+	waitInterval time.Duration,
 	downsampleConcurrency int,
 	objStoreConfig *extflag.PathOrContent,
 	comp component.Component,
@@ -113,31 +114,32 @@ func RunDownsample(
 			defer runutil.CloseWithLogOnErr(logger, bkt, "bucket client")
 			statusProber.Ready()
 
-			level.Info(logger).Log("msg", "start first pass of downsampling")
-			metas, _, err := metaFetcher.Fetch(ctx)
-			if err != nil {
-				return errors.Wrap(err, "sync before first pass of downsampling")
-			}
-
-			for _, meta := range metas {
-				groupKey := meta.Thanos.GroupKey()
-				metrics.downsamples.WithLabelValues(groupKey)
-				metrics.downsampleFailures.WithLabelValues(groupKey)
-			}
-			if err := downsampleBucket(ctx, logger, metrics, bkt, metas, dataDir, downsampleConcurrency, hashFunc); err != nil {
-				return errors.Wrap(err, "downsampling failed")
-			}
+			return runutil.Repeat(waitInterval, ctx.Done(), func() error {
+				level.Info(logger).Log("msg", "start first pass of downsampling")
+				metas, _, err := metaFetcher.Fetch(ctx)
+				if err != nil {
+					return errors.Wrap(err, "sync before first pass of downsampling")
+				}
 
-			level.Info(logger).Log("msg", "start second pass of downsampling")
-			metas, _, err = metaFetcher.Fetch(ctx)
-			if err != nil {
-				return errors.Wrap(err, "sync before second pass of downsampling")
-			}
-			if err := downsampleBucket(ctx, logger, metrics, bkt, metas, dataDir, downsampleConcurrency, hashFunc); err != nil {
-				return errors.Wrap(err, "downsampling failed")
-			}
+				for _, meta := range metas {
+					groupKey := meta.Thanos.GroupKey()
+					metrics.downsamples.WithLabelValues(groupKey)
+					metrics.downsampleFailures.WithLabelValues(groupKey)
+				}
+				if err := downsampleBucket(ctx, logger, metrics, bkt, metas, dataDir, downsampleConcurrency, hashFunc); err != nil {
+					return errors.Wrap(err, "downsampling failed")
+				}
 
-			return nil
+				level.Info(logger).Log("msg", "start second pass of downsampling")
+				metas, _, err = metaFetcher.Fetch(ctx)
+				if err != nil {
+					return errors.Wrap(err, "sync before second pass of downsampling")
+				}
+				if err := downsampleBucket(ctx, logger, metrics, bkt, metas, dataDir, downsampleConcurrency, hashFunc); err != nil {
+					return errors.Wrap(err, "downsampling failed")
+				}
+				return nil
+			})
 		}, func(error) {
 			cancel()
 		})
diff --git a/cmd/thanos/tools_bucket.go b/cmd/thanos/tools_bucket.go
index d9d612362e..6964b4c71b 100644
--- a/cmd/thanos/tools_bucket.go
+++ b/cmd/thanos/tools_bucket.go
@@ -129,6 +129,7 @@ type bucketReplicateConfig struct {
 }
 
 type bucketDownsampleConfig struct {
+	waitInterval          time.Duration
 	downsampleConcurrency int
 	dataDir               string
 	hashFunc              string
@@ -224,6 +225,8 @@ func (tbc *bucketRewriteConfig) registerBucketRewriteFlag(cmd extkingpin.FlagCla
 }
 
 func (tbc *bucketDownsampleConfig) registerBucketDownsampleFlag(cmd extkingpin.FlagClause) *bucketDownsampleConfig {
+	cmd.Flag("wait-interval", "Wait interval between downsample runs.").
+		Default("5m").DurationVar(&tbc.waitInterval)
 	cmd.Flag("downsample.concurrency", "Number of goroutines to use when downsampling blocks.").
 		Default("1").IntVar(&tbc.downsampleConcurrency)
 	cmd.Flag("data-dir", "Data directory in which to cache blocks and process downsamplings.").
@@ -747,7 +750,8 @@ func registerBucketDownsample(app extkingpin.AppClause, objStoreConfig *extflag.
 	tbc.registerBucketDownsampleFlag(cmd)
 
 	cmd.Setup(func(g *run.Group, logger log.Logger, reg *prometheus.Registry, tracer opentracing.Tracer, _ <-chan struct{}, _ bool) error {
-		return RunDownsample(g, logger, reg, *httpAddr, *httpTLSConfig, time.Duration(*httpGracePeriod), tbc.dataDir, tbc.downsampleConcurrency, objStoreConfig, component.Downsample, metadata.HashFunc(tbc.hashFunc))
+		return RunDownsample(g, logger, reg, *httpAddr, *httpTLSConfig, time.Duration(*httpGracePeriod), tbc.dataDir,
+			tbc.waitInterval, tbc.downsampleConcurrency, objStoreConfig, component.Downsample, metadata.HashFunc(tbc.hashFunc))
 	})
 }
 
diff --git a/docs/components/tools.md b/docs/components/tools.md
index efa9dc475b..80ceed9585 100644
--- a/docs/components/tools.md
+++ b/docs/components/tools.md
@@ -652,6 +652,7 @@ Flags:
                               format details:
                               https://thanos.io/tip/thanos/tracing.md/#configuration
       --version               Show application version.
+      --wait-interval=5m      Wait interval between downsample runs.
 
 ```