diff --git a/src/jit/corePlugins.js b/src/jit/corePlugins.js
index 1ab4fb978e79..9b2f28cf77a4 100644
--- a/src/jit/corePlugins.js
+++ b/src/jit/corePlugins.js
@@ -3,6 +3,7 @@ import * as corePlugins from '../plugins'
 import buildMediaQuery from '../util/buildMediaQuery'
 import prefixSelector from '../util/prefixSelector'
 import {
+  applyPseudoToMarker,
   updateLastClasses,
   updateAllClasses,
   transformAllSelectors,
@@ -156,7 +157,7 @@ export default {
       )
     }
 
-    let baseGroupSelector = prefixSelector(config('prefix'), '.group')
+    let groupMarker = prefixSelector(config('prefix'), '.group')
     for (let variant of pseudoVariants) {
       let [variantName, state] = Array.isArray(variant) ? variant : [variant, variant]
       let groupVariantName = `group-${variantName}`
@@ -165,7 +166,7 @@ export default {
         groupVariantName,
         transformAllSelectors((selector) => {
           let variantSelector = updateAllClasses(selector, (className) => {
-            if (`.${className}` === baseGroupSelector) return className
+            if (`.${className}` === groupMarker) return className
             return `${groupVariantName}${config('separator')}${className}`
           })
 
@@ -173,28 +174,39 @@ export default {
             return null
           }
 
-          let states = [state]
+          return applyPseudoToMarker(
+            variantSelector,
+            groupMarker,
+            state,
+            (marker, selector) => `${marker} ${selector}`
+          )
+        })
+      )
+    }
 
-          // Stack group variants
-          let baseGroupIdx = variantSelector.indexOf(baseGroupSelector + ':')
-          if (baseGroupIdx !== -1) {
-            let groupClassName = variantSelector.slice(
-              baseGroupIdx,
-              variantSelector.indexOf(' ', baseGroupIdx)
-            )
+    let peerMarker = prefixSelector(config('prefix'), '.peer')
+    for (let variant of pseudoVariants) {
+      let [variantName, state] = Array.isArray(variant) ? variant : [variant, variant]
+      let peerVariantName = `peer-${variantName}`
 
-            // Pick all the states
-            states = states.concat(
-              variantSelector
-                .slice(baseGroupIdx + baseGroupSelector.length + 1, groupClassName.length)
-                .split(':')
-            )
+      addVariant(
+        peerVariantName,
+        transformAllSelectors((selector) => {
+          let variantSelector = updateAllClasses(selector, (className) => {
+            if (`.${className}` === peerMarker) return className
+            return `${peerVariantName}${config('separator')}${className}`
+          })
 
-            // Remove the base `.group:...`
-            variantSelector = variantSelector.replace(groupClassName, '')
+          if (variantSelector === selector) {
+            return null
           }
 
-          return `${[baseGroupSelector, ...states].join(':')} ${variantSelector}`
+          return applyPseudoToMarker(
+            variantSelector,
+            peerMarker,
+            state,
+            (marker, selector) => `${marker} ~ ${selector}`
+          )
         })
       )
     }
diff --git a/src/util/pluginUtils.js b/src/util/pluginUtils.js
index 33abffc20c54..9d12a87422a8 100644
--- a/src/util/pluginUtils.js
+++ b/src/util/pluginUtils.js
@@ -4,6 +4,24 @@ import createColor from 'color'
 import escapeCommas from './escapeCommas'
 import { withAlphaValue } from './withAlphaVariable'
 
+export function applyPseudoToMarker(selector, marker, state, join) {
+  let states = [state]
+
+  let targetIdx = selector.indexOf(marker + ':')
+
+  if (targetIdx !== -1) {
+    let existingTarget = selector.slice(targetIdx, selector.indexOf(' ', targetIdx))
+
+    states = states.concat(
+      selector.slice(targetIdx + marker.length + 1, existingTarget.length).split(':')
+    )
+
+    selector = selector.replace(existingTarget, '')
+  }
+
+  return join(`${[marker, ...states].join(':')}`, selector)
+}
+
 export function updateAllClasses(selectors, updateClass) {
   let parser = selectorParser((selectors) => {
     selectors.walkClasses((sel) => {
diff --git a/tests/jit/variants.test.css b/tests/jit/variants.test.css
index cba8caaa841c..9d577306cf5b 100644
--- a/tests/jit/variants.test.css
+++ b/tests/jit/variants.test.css
@@ -378,6 +378,161 @@
   box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
     var(--tw-shadow);
 }
+.peer:first-child ~ .peer-first\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:last-child ~ .peer-last\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:only-child ~ .peer-only\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:nth-child(odd) ~ .peer-odd\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:nth-child(even) ~ .peer-even\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:first-of-type ~ .peer-first-of-type\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:last-of-type ~ .peer-last-of-type\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:only-of-type ~ .peer-only-of-type\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:visited ~ .peer-visited\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:target ~ .peer-target\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:default ~ .peer-default\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:checked ~ .peer-checked\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:indeterminate ~ .peer-indeterminate\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:placeholder-shown ~ .peer-placeholder-shown\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:autofill ~ .peer-autofill\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:required ~ .peer-required\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:valid ~ .peer-valid\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:invalid ~ .peer-invalid\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:in-range ~ .peer-in-range\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:out-of-range ~ .peer-out-of-range\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:read-only ~ .peer-read-only\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:empty ~ .peer-empty\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:focus-within ~ .peer-focus-within\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:hover ~ .peer-hover\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:focus ~ .peer-focus\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:focus:hover ~ .peer-focus\:peer-hover\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:focus-visible ~ .peer-focus-visible\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:active ~ .peer-active\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:disabled ~ .peer-disabled\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:disabled:focus:hover ~ .peer-disabled\:peer-focus\:peer-hover\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
+.peer:disabled:focus:hover ~ .peer-disabled\:peer-focus\:peer-hover\:first\:shadow-md:first-child {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
 [dir='ltr'] .ltr\:shadow-md {
   --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
   box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
@@ -412,6 +567,11 @@
   box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
     var(--tw-shadow);
 }
+.dark .peer:disabled:focus:hover ~ .dark\:peer-disabled\:peer-focus\:peer-hover\:shadow-md {
+  --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
+  box-shadow: var(--tw-ring-offset-shadow, 0 0 #0000), var(--tw-ring-shadow, 0 0 #0000),
+    var(--tw-shadow);
+}
 @media (min-width: 640px) {
   .sm\:shadow-md {
     --tw-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
diff --git a/tests/jit/variants.test.html b/tests/jit/variants.test.html
index 3444bc462c69..9fb44452efeb 100644
--- a/tests/jit/variants.test.html
+++ b/tests/jit/variants.test.html
@@ -78,6 +78,36 @@
     <div class="group-read-only:shadow-md"></div>
     <div class="group-empty:shadow-md"></div>
 
+    <!-- Peer variants -->
+    <div class="peer-first:shadow-md"></div>
+    <div class="peer-last:shadow-md"></div>
+    <div class="peer-only:shadow-md"></div>
+    <div class="peer-even:shadow-md"></div>
+    <div class="peer-odd:shadow-md"></div>
+    <div class="peer-first-of-type:shadow-md"></div>
+    <div class="peer-last-of-type:shadow-md"></div>
+    <div class="peer-only-of-type:shadow-md"></div>
+    <div class="peer-hover:shadow-md"></div>
+    <div class="peer-focus:shadow-md"></div>
+    <div class="peer-disabled:shadow-md"></div>
+    <div class="peer-active:shadow-md"></div>
+    <div class="peer-target:shadow-md"></div>
+    <div class="peer-visited:shadow-md"></div>
+    <div class="peer-default:shadow-md"></div>
+    <div class="peer-checked:shadow-md"></div>
+    <div class="peer-indeterminate:shadow-md"></div>
+    <div class="peer-placeholder-shown:shadow-md"></div>
+    <div class="peer-autofill:shadow-md"></div>
+    <div class="peer-focus-within:shadow-md"></div>
+    <div class="peer-focus-visible:shadow-md"></div>
+    <div class="peer-required:shadow-md"></div>
+    <div class="peer-valid:shadow-md"></div>
+    <div class="peer-invalid:shadow-md"></div>
+    <div class="peer-in-range:shadow-md"></div>
+    <div class="peer-out-of-range:shadow-md"></div>
+    <div class="peer-read-only:shadow-md"></div>
+    <div class="peer-empty:shadow-md"></div>
+
     <!-- Reduced motion variants -->
     <div class="motion-safe:shadow-md"></div>
     <div class="motion-reduce:shadow-md"></div>
@@ -109,5 +139,11 @@
     <div class="group-disabled:group-focus:group-hover:shadow-md"></div>
     <div class="dark:group-disabled:group-focus:group-hover:shadow-md"></div>
     <div class="group-disabled:group-focus:group-hover:first:shadow-md"></div>
+
+    <!-- Stacked peer variants -->
+    <div class="peer-focus:peer-hover:shadow-md"></div>
+    <div class="peer-disabled:peer-focus:peer-hover:shadow-md"></div>
+    <div class="dark:peer-disabled:peer-focus:peer-hover:shadow-md"></div>
+    <div class="peer-disabled:peer-focus:peer-hover:first:shadow-md"></div>
   </body>
 </html>