diff --git a/sphinx/domains/python.py b/sphinx/domains/python.py
index a634a51d2b2..fd43b15b262 100644
--- a/sphinx/domains/python.py
+++ b/sphinx/domains/python.py
@@ -396,7 +396,7 @@ def make_xrefs(self, rolename: str, domain: str, target: str,
                 results.append(self.make_xref(rolename, domain, sub_target,
                                               innernode, contnode, env, inliner, location))
 
-            if sub_target in ('Literal', 'typing.Literal'):
+            if sub_target in ('Literal', 'typing.Literal', '~typing.Literal'):
                 in_literal = True
 
         return results