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leiden alg with igraph flavor causes out of bounds freezing #2969

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3 tasks done
RubenVanEsch opened this issue Mar 28, 2024 · 19 comments · May be fixed by #3041
Open
3 tasks done

leiden alg with igraph flavor causes out of bounds freezing #2969

RubenVanEsch opened this issue Mar 28, 2024 · 19 comments · May be fixed by #3041
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@RubenVanEsch
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Please make sure these conditions are met

  • I have checked that this issue has not already been reported.
  • I have confirmed this bug exists on the latest version of scanpy.
  • (optional) I have confirmed this bug exists on the main branch of scanpy.

What happened?

was running the standard pipeline on some data and when i run
sc.tl.leiden(em_adata,flavor='igraph',n_iterations=2,random_state=1653,directed=False)
it spits out infinite lines of ignored exceptions. it does not actually crash the kernel, but does bog it down and causes everything to to take much more time than necesarry.
I am working in a conda env on a Win 10 , 64bit, x64 system
the problem also occurs using the pbmc3k dataset

Minimal code sample

# example with own data, but same happens with pbmc3k data
sc.pp.filter_cells(em_adata, min_genes=200)
sc.pp.filter_genes(em_adata, min_cells=3)
em_adata.shape
# [out] -> (42753, 21636)

sc.pp.calculate_qc_metrics(em_adata, qc_vars=["mt"], percent_top=None, log1p=False, inplace=True)
em_adata.obs["outlier_mt"] = em_adata.obs.pct_counts_mt > 15
em_adata.obs["outlier_total"] = em_adata.obs.total_counts > 30000
em_adata.obs["outlier_ngenes"] = em_adata.obs.n_genes_by_counts > 6000
em_adata = em_adata[~em_adata.obs["outlier_mt"], :]
em_adata = em_adata[~em_adata.obs["outlier_total"], :]
em_adata = em_adata[~em_adata.obs["outlier_ngenes"], :]
sc.pp.filter_genes(em_adata,min_cells=1)

sc.pp.scrublet(em_adata)
em_adata.layers['counts'] = em_adata.X.copy()
sc.pp.normalize_total(em_adata)
sc.pp.log1p(em_adata)
sc.pp.highly_variable_genes(em_adata,flavor='seurat')
sc.pl.highly_variable_genes(em_adata)
em_adata = em_adata[:, em_adata.var["highly_variable"]]
em_adata.shape
# [out] -> (41749, 1425)
sc.pp.pca(em_adata, n_comps=50)
sc.pp.neighbors(em_adata)
sc.tl.umap(em_adata)
sc.tl.leiden(em_adata,flavor='igraph',n_iterations=2,random_state=1653,directed=False)

Error output

Exception ignored in: <class 'ValueError'>
Traceback (most recent call last):
  File "numpy\\random\\mtrand.pyx", line 780, in numpy.random.mtrand.RandomState.randint
  File "numpy\\random\\_bounded_integers.pyx", line 2881, in numpy.random._bounded_integers._rand_int32
ValueError: high is out of bounds for int32

Versions

conda env:
# Name                    Version                   Build  Channel
_r-mutex                  1.0.0               anacondar_1
anndata                   0.10.6                   pypi_0    pypi
anyio                     4.3.0                    pypi_0    pypi
argon2-cffi               23.1.0                   pypi_0    pypi
argon2-cffi-bindings      21.2.0          py311h2bbff1b_0
array-api-compat          1.5.1                    pypi_0    pypi
arrow                     1.3.0                    pypi_0    pypi
asttokens                 2.4.1                    pypi_0    pypi
async-lru                 2.0.4           py311haa95532_0
attrs                     23.2.0                   pypi_0    pypi
babel                     2.14.0                   pypi_0    pypi
beautifulsoup4            4.12.3                   pypi_0    pypi
bleach                    6.1.0                    pypi_0    pypi
brotli-python             1.0.9           py311hd77b12b_7
bzip2                     1.0.8                h2bbff1b_5
ca-certificates           2023.12.12           haa95532_0
certifi                   2024.2.2        py311haa95532_0
cffi                      1.16.0          py311h2bbff1b_0
charset-normalizer        3.3.2                    pypi_0    pypi
colorama                  0.4.6           py311haa95532_0
comm                      0.2.2                    pypi_0    pypi
contourpy                 1.2.0                    pypi_0    pypi
cycler                    0.12.1                   pypi_0    pypi
debugpy                   1.8.1                    pypi_0    pypi
decorator                 5.1.1              pyhd3eb1b0_0
defusedxml                0.7.1              pyhd3eb1b0_0
executing                 2.0.1                    pypi_0    pypi
fastjsonschema            2.19.1                   pypi_0    pypi
fonttools                 4.50.0                   pypi_0    pypi
fqdn                      1.5.1                    pypi_0    pypi
h11                       0.14.0                   pypi_0    pypi
h5py                      3.10.0                   pypi_0    pypi
httpcore                  1.0.4                    pypi_0    pypi
httpx                     0.27.0                   pypi_0    pypi
idna                      3.6                      pypi_0    pypi
igraph                    0.11.4                   pypi_0    pypi
imageio                   2.34.0                   pypi_0    pypi
ipykernel                 6.29.3                   pypi_0    pypi
ipython                   8.22.2                   pypi_0    pypi
ipywidgets                8.1.2                    pypi_0    pypi
isoduration               20.11.0                  pypi_0    pypi
jedi                      0.19.1                   pypi_0    pypi
jinja2                    3.1.3           py311haa95532_0
joblib                    1.3.2                    pypi_0    pypi
json5                     0.9.22                   pypi_0    pypi
jsonpointer               2.4                      pypi_0    pypi
jsonschema                4.21.1                   pypi_0    pypi
jsonschema-specifications 2023.12.1                pypi_0    pypi
jupyter-client            8.6.1                    pypi_0    pypi
jupyter-core              5.7.2                    pypi_0    pypi
jupyter-events            0.9.1                    pypi_0    pypi
jupyter-lsp               2.2.4                    pypi_0    pypi
jupyter-server            2.13.0                   pypi_0    pypi
jupyter-server-terminals  0.5.3                    pypi_0    pypi
jupyter_client            8.6.0           py311haa95532_0
jupyter_core              5.5.0           py311haa95532_0
jupyter_events            0.8.0           py311haa95532_0
jupyter_server            2.10.0          py311haa95532_0
jupyter_server_terminals  0.4.4           py311haa95532_1
jupyterlab                4.1.5                    pypi_0    pypi
jupyterlab-pygments       0.3.0                    pypi_0    pypi
jupyterlab-server         2.25.4                   pypi_0    pypi
jupyterlab-widgets        3.0.10                   pypi_0    pypi
jupyterlab_pygments       0.1.2                      py_0
jupyterlab_server         2.25.1          py311haa95532_0
kiwisolver                1.4.5                    pypi_0    pypi
lazy-loader               0.3                      pypi_0    pypi
legacy-api-wrap           1.4                      pypi_0    pypi
leidenalg                 0.10.2                   pypi_0    pypi
libffi                    3.4.4                hd77b12b_0
libsodium                 1.0.18               h62dcd97_0
llvmlite                  0.42.0                   pypi_0    pypi
m2w64-bwidget             1.9.10                        2
m2w64-bzip2               1.0.6                         6
m2w64-expat               2.1.1                         2
m2w64-fftw                3.3.4                         6
m2w64-flac                1.3.1               # Name                    Version                   Build  Channel
_r-mutex                  1.0.0               anacondar_1  
anndata                   0.10.6                   pypi_0    pypi
anyio                     4.3.0                    pypi_0    pypi
argon2-cffi               23.1.0                   pypi_0    pypi
argon2-cffi-bindings      21.2.0          py311h2bbff1b_0  
array-api-compat          1.5.1                    pypi_0    pypi
arrow                     1.3.0                    pypi_0    pypi
asttokens                 2.4.1                    pypi_0    pypi
async-lru                 2.0.4           py311haa95532_0  
attrs                     23.2.0                   pypi_0    pypi
babel                     2.14.0                   pypi_0    pypi
beautifulsoup4            4.12.3                   pypi_0    pypi
bleach                    6.1.0                    pypi_0    pypi
brotli-python             1.0.9           py311hd77b12b_7  
bzip2                     1.0.8                h2bbff1b_5  
ca-certificates           2023.12.12           haa95532_0  
certifi                   2024.2.2        py311haa95532_0  
cffi                      1.16.0          py311h2bbff1b_0  
chardet                   5.2.0                    pypi_0    pypi
charset-normalizer        3.3.2                    pypi_0    pypi
colorama                  0.4.6           py311haa95532_0  
comm                      0.2.2                    pypi_0    pypi
contourpy                 1.2.0                    pypi_0    pypi
cycler                    0.12.1                   pypi_0    pypi
debugpy                   1.8.1                    pypi_0    pypi
decorator                 5.1.1              pyhd3eb1b0_0  
defusedxml                0.7.1              pyhd3eb1b0_0  
executing                 2.0.1                    pypi_0    pypi
fastjsonschema            2.19.1                   pypi_0    pypi
fonttools                 4.50.0                   pypi_0    pypi
fqdn                      1.5.1                    pypi_0    pypi
h11                       0.14.0                   pypi_0    pypi
h5py                      3.10.0                   pypi_0    pypi
httpcore                  1.0.4                    pypi_0    pypi
httpx                     0.27.0                   pypi_0    pypi
idna                      3.6                      pypi_0    pypi
igraph                    0.11.4                   pypi_0    pypi
imageio                   2.34.0                   pypi_0    pypi
ipykernel                 6.29.3                   pypi_0    pypi
ipython                   8.22.2                   pypi_0    pypi
ipywidgets                8.1.2                    pypi_0    pypi
isoduration               20.11.0                  pypi_0    pypi
jedi                      0.19.1                   pypi_0    pypi
jinja2                    3.1.3           py311haa95532_0  
joblib                    1.3.2                    pypi_0    pypi
json5                     0.9.22                   pypi_0    pypi
jsonpointer               2.4                      pypi_0    pypi
jsonschema                4.21.1                   pypi_0    pypi
jsonschema-specifications 2023.12.1                pypi_0    pypi
jupyter-client            8.6.1                    pypi_0    pypi
jupyter-core              5.7.2                    pypi_0    pypi
jupyter-events            0.9.1                    pypi_0    pypi
jupyter-lsp               2.2.4                    pypi_0    pypi
jupyter-server            2.13.0                   pypi_0    pypi
jupyter-server-terminals  0.5.3                    pypi_0    pypi
jupyter_client            8.6.0           py311haa95532_0  
jupyter_core              5.5.0           py311haa95532_0  
jupyter_events            0.8.0           py311haa95532_0  
jupyter_server            2.10.0          py311haa95532_0  
jupyter_server_terminals  0.4.4           py311haa95532_1  
jupyterlab                4.1.5                    pypi_0    pypi
jupyterlab-pygments       0.3.0                    pypi_0    pypi
jupyterlab-server         2.25.4                   pypi_0    pypi
jupyterlab-widgets        3.0.10                   pypi_0    pypi
jupyterlab_pygments       0.1.2                      py_0  
jupyterlab_server         2.25.1          py311haa95532_0  
kiwisolver                1.4.5                    pypi_0    pypi
lazy-loader               0.3                      pypi_0    pypi
legacy-api-wrap           1.4                      pypi_0    pypi
leidenalg                 0.10.2                   pypi_0    pypi
libffi                    3.4.4                hd77b12b_0  
libsodium                 1.0.18               h62dcd97_0  
llvmlite                  0.42.0                   pypi_0    pypi
m2w64-bwidget             1.9.10                        2  
m2w64-bzip2               1.0.6                         6  
m2w64-expat               2.1.1                         2  
m2w64-fftw                3.3.4                         6  
m2w64-flac                1.3.1                         3  
m2w64-gcc-libgfortran     5.3.0                         6  
m2w64-gcc-libs            5.3.0                         7  
m2w64-gcc-libs-core       5.3.0                         7  
m2w64-gettext             0.19.7                        2  
m2w64-gmp                 6.1.0                         2  
m2w64-gsl                 2.1                           2  
m2w64-libiconv            1.14                          6  
m2w64-libjpeg-turbo       1.4.2                         3  
m2w64-libogg              1.3.2                         3  
m2w64-libpng              1.6.21                        2  
m2w64-libsndfile          1.0.26                        2  
m2w64-libsodium           1.0.10                        2  
m2w64-libtiff             4.0.6                         2  
m2w64-libvorbis           1.3.5                         2  
m2w64-libwinpthread-git   5.0.0.4634.697f757               2  
m2w64-libxml2             2.9.3                         4  
m2w64-mpfr                3.1.4                         4  
m2w64-openblas            0.2.19                        1  
m2w64-pcre                8.38                          2  
m2w64-speex               1.2rc2                        3  
m2w64-speexdsp            1.2rc3                        3  
m2w64-tcl                 8.6.5                         3  
m2w64-tk                  8.6.5                         3  
m2w64-tktable             2.10                          5  
m2w64-wineditline         2.101                         5  
m2w64-xz                  5.2.2                         2  
m2w64-zeromq              4.1.4                         2  
m2w64-zlib                1.2.8                        10  
markupsafe                2.1.5                    pypi_0    pypi
matplotlib                3.8.3                    pypi_0    pypi
matplotlib-inline         0.1.6           py311haa95532_0  
mistune                   3.0.2                    pypi_0    pypi
msys2-conda-epoch         20160418                      1  
natsort                   8.4.0                    pypi_0    pypi
nbclient                  0.10.0                   pypi_0    pypi
nbconvert                 7.16.2                   pypi_0    pypi
nbformat                  5.10.3                   pypi_0    pypi
nest-asyncio              1.6.0           py311haa95532_0  
networkx                  3.2.1                    pypi_0    pypi
notebook                  7.1.2                    pypi_0    pypi
notebook-shim             0.2.4                    pypi_0    pypi
numba                     0.59.1                   pypi_0    pypi
numpy                     1.26.4                   pypi_0    pypi
openssl                   3.0.13               h2bbff1b_0  
overrides                 7.7.0                    pypi_0    pypi
packaging                 24.0                     pypi_0    pypi
pandas                    2.2.1                    pypi_0    pypi
pandocfilters             1.5.1                    pypi_0    pypi
parso                     0.8.3              pyhd3eb1b0_0  
patsy                     0.5.6                    pypi_0    pypi
pillow                    10.2.0                   pypi_0    pypi
pip                       23.3.1          py311haa95532_0  
platformdirs              4.2.0                    pypi_0    pypi
plotly                    5.20.0                   pypi_0    pypi
prometheus-client         0.20.0                   pypi_0    pypi
prometheus_client         0.14.1          py311haa95532_0  
prompt-toolkit            3.0.43          py311haa95532_0  
prompt_toolkit            3.0.43               hd3eb1b0_0  
psutil                    5.9.8                    pypi_0    pypi
pure_eval                 0.2.2              pyhd3eb1b0_0  
pycparser                 2.21               pyhd3eb1b0_0  
pygments                  2.17.2                   pypi_0    pypi
pynndescent               0.5.11                   pypi_0    pypi
pyparsing                 3.1.2                    pypi_0    pypi
pysocks                   1.7.1           py311haa95532_0  
python                    3.11.8               he1021f5_0  
python-dateutil           2.9.0.post0              pypi_0    pypi
python-fastjsonschema     2.16.2          py311haa95532_0  
python-json-logger        2.0.7           py311haa95532_0  
pytz                      2023.3.post1    py311haa95532_0  
pywin32                   306                      pypi_0    pypi
pywinpty                  2.0.13                   pypi_0    pypi
pyyaml                    6.0.1           py311h2bbff1b_0  
pyzmq                     25.1.2          py311hd77b12b_0  
r-askpass                 1.0                       r36_0  
r-assertthat              0.2.1             r36h6115d3f_0  
r-backports               1.1.4             r36h6115d3f_0  
r-base                    3.6.1                hf18239d_1  
r-base64enc               0.1_3             r36h6115d3f_4  
r-bh                      1.69.0_1          r36h6115d3f_0  
r-boot                    1.3_20            r36h6115d3f_0  
r-broom                   0.5.2             r36h6115d3f_0  
r-callr                   3.2.0             r36h6115d3f_0  
r-caret                   6.0_83            r36h6115d3f_0  
r-cellranger              1.1.0             r36h6115d3f_0  
r-class                   7.3_15            r36h6115d3f_0  
r-cli                     1.1.0             r36h6115d3f_0  
r-clipr                   0.6.0             r36h6115d3f_0  
r-cluster                 2.0.8             r36h6115d3f_0  
r-codetools               0.2_16            r36h6115d3f_0  
r-colorspace              1.4_1             r36h6115d3f_0  
r-crayon                  1.3.4             r36h6115d3f_0  
r-curl                    3.3               r36h6115d3f_0  
r-data.table              1.12.2            r36h6115d3f_0  
r-dbi                     1.0.0             r36h6115d3f_0  
r-dbplyr                  1.4.0             r36h6115d3f_0  
r-dichromat               2.0_0             r36h6115d3f_4  
r-digest                  0.6.18            r36h6115d3f_0  
r-dplyr                   0.8.0.1           r36h6115d3f_0  
r-ellipsis                0.1.0             r36h6115d3f_0  
r-essentials              3.6.0                     r36_0  
r-evaluate                0.13              r36h6115d3f_0  
r-fansi                   0.4.0             r36h6115d3f_0  
r-forcats                 0.4.0             r36h6115d3f_0  
r-foreach                 1.4.4             r36h6115d3f_0  
r-foreign                 0.8_71            r36h6115d3f_0  
r-formatr                 1.6               r36h6115d3f_0  
r-fs                      1.2.7             r36h6115d3f_0  
r-generics                0.0.2             r36h6115d3f_0  
r-ggplot2                 3.1.1             r36h6115d3f_0  
r-glmnet                  2.0_16            r36h6115d3f_0  
r-glue                    1.3.1             r36h6115d3f_0  
r-gower                   0.2.0             r36h6115d3f_0  
r-gtable                  0.3.0             r36h6115d3f_0  
r-haven                   2.1.0             r36h6115d3f_0  
r-hexbin                  1.27.2            r36h6115d3f_0  
r-highr                   0.8               r36h6115d3f_0  
r-hms                     0.4.2             r36h6115d3f_0  
r-htmltools               0.3.6             r36h6115d3f_0  
r-htmlwidgets             1.3               r36h6115d3f_0  
r-httpuv                  1.5.1             r36h6115d3f_0  
r-httr                    1.4.0             r36h6115d3f_0  
r-ipred                   0.9_8             r36h6115d3f_0  
r-irdisplay               0.7.0             r36h6115d3f_0  
r-irkernel                0.8.15                    r36_0  
r-iterators               1.0.10            r36h6115d3f_0  
r-jsonlite                1.6               r36h6115d3f_0  
r-kernsmooth              2.23_15           r36h6115d3f_4  
r-knitr                   1.22              r36h6115d3f_0  
r-labeling                0.3               r36h6115d3f_4  
r-later                   0.8.0             r36h6115d3f_0  
r-lattice                 0.20_38           r36h6115d3f_0  
r-lava                    1.6.5             r36h6115d3f_0  
r-lazyeval                0.2.2             r36h6115d3f_0  
r-lubridate               1.7.4             r36h6115d3f_0  
r-magrittr                1.5               r36h6115d3f_4  
r-maps                    3.3.0             r36h6115d3f_0  
r-markdown                0.9               r36h6115d3f_0  
r-mass                    7.3_51.3          r36h6115d3f_0  
r-matrix                  1.2_17            r36h6115d3f_0  
r-mgcv                    1.8_28            r36h6115d3f_0  
r-mime                    0.6               r36h6115d3f_0  
r-modelmetrics            1.2.2             r36h6115d3f_0  
r-modelr                  0.1.4             r36h6115d3f_0  
r-munsell                 0.5.0             r36h6115d3f_0  
r-nlme                    3.1_139           r36h6115d3f_0  
r-nnet                    7.3_12            r36h6115d3f_0  
r-numderiv                2016.8_1          r36h6115d3f_0  
r-openssl                 1.3               r36h6115d3f_0  
r-pbdzmq                  0.3_3             r36h6115d3f_0  
r-pillar                  1.3.1             r36h6115d3f_0  
r-pkgconfig               2.0.2             r36h6115d3f_0  
r-plogr                   0.2.0             r36h6115d3f_0  
r-plyr                    1.8.4             r36h6115d3f_0  
r-prettyunits             1.0.2             r36h6115d3f_0  
r-processx                3.3.0             r36h6115d3f_0  
r-prodlim                 2018.04.18        r36h6115d3f_0  
r-progress                1.2.0             r36h6115d3f_0  
r-promises                1.0.1             r36h6115d3f_0  
r-ps                      1.3.0             r36h6115d3f_0  
r-purrr                   0.3.2             r36h6115d3f_0  
r-quantmod                0.4_14            r36h6115d3f_0  
r-r6                      2.4.0             r36h6115d3f_0  
r-randomforest            4.6_14            r36h6115d3f_0  
r-rbokeh                  0.6.3                     r36_0  
r-rcolorbrewer            1.1_2             r36h6115d3f_0  
r-rcpp                    1.0.1             r36h6115d3f_0  
r-rcpproll                0.3.0             r36h6115d3f_0  
r-readr                   1.3.1             r36h6115d3f_0  
r-readxl                  1.3.1             r36h6115d3f_0  
r-recipes                 0.1.5             r36h6115d3f_0  
r-recommended             3.6.0                     r36_0  
r-rematch                 1.0.1             r36h6115d3f_0  
r-repr                    0.19.2            r36h6115d3f_0  
r-reprex                  0.2.1             r36h6115d3f_0  
r-reshape2                1.4.3             r36h6115d3f_0  
r-rlang                   0.3.4             r36h6115d3f_0  
r-rmarkdown               1.12              r36h6115d3f_0  
r-rpart                   4.1_15            r36h6115d3f_0  
r-rstudioapi              0.10              r36h6115d3f_0  
r-rvest                   0.3.3             r36h6115d3f_0  
r-scales                  1.0.0             r36h6115d3f_0  
r-selectr                 0.4_1             r36h6115d3f_0  
r-shiny                   1.3.2             r36h6115d3f_0  
r-sourcetools             0.1.7             r36h6115d3f_0  
r-spatial                 7.3_11            r36h6115d3f_4  
r-squarem                 2017.10_1         r36h6115d3f_0  
r-stringi                 1.4.3             r36h6115d3f_0  
r-stringr                 1.4.0             r36h6115d3f_0  
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r-tibble                  2.1.1             r36h6115d3f_0  
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r-tidyverse               1.2.1             r36h6115d3f_0  
r-timedate                3043.102          r36h6115d3f_0  
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r-viridislite             0.3.0             r36h6115d3f_0  
r-whisker                 0.3_2             r36h6115d3f_4  
r-withr                   2.1.2             r36h6115d3f_0  
r-xfun                    0.6               r36h6115d3f_0  
r-xml2                    1.2.0             r36h6115d3f_0  
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r-yaml                    2.2.0             r36h6115d3f_0  
r-zoo                     1.8_5             r36h6115d3f_0  
referencing               0.33.0                   pypi_0    pypi
requests                  2.31.0          py311haa95532_1  
rfc3339-validator         0.1.4           py311haa95532_0  
rfc3986-validator         0.1.1           py311haa95532_0  
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tk                        8.6.12               h2bbff1b_0  
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winpty                    0.4.3                         4  
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zeromq                    4.3.5                hd77b12b_0  
zlib                      1.2.13               h8cc25b3_0  
@ilan-gold
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ilan-gold commented Apr 3, 2024

@RubenVanEsch Can you provide a more minimally reproducible example?

For example, paring down a bit the above to just:

import scanpy as sc

em_adata = sc.datasets.pbmc3k()

sc.pp.pca(em_adata, n_comps=50)
sc.pp.neighbors(em_adata)
sc.tl.umap(em_adata)
sc.tl.leiden(em_adata,flavor='igraph',n_iterations=2,random_state=1653,directed=False)

does not yield any error. Could you share your system info i.e., widows or mac?

@RubenVanEsch
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RubenVanEsch commented Apr 3, 2024

@ilan-gold your minimal example causes the exact same error:

Exception ignored in: <class 'ValueError'>
Traceback (most recent call last):
File "numpy\random\mtrand.pyx", line 780, in numpy.random.mtrand.RandomState.randint
File "numpy\random\_bounded_integers.pyx", line 2881, in numpy.random._bounded_integers._rand_int32
ValueError: high is out of bounds for int32

if you are curious, it spits the error out 14.210 times (71050 lines of error message)

EDIT: the random state does not seem to matter btw, also happens with different random states

@ilan-gold
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Ok @RubenVanEsch we have to assume that this is a windows problem then. I think we will try to set up a test job and hopefully this catches the problem, although will likely catch others. What happens without a random_state set?

@RubenVanEsch
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@ilan-gold same thing without random state
I think there might be some windows error relating to numpy on linux defaulting to 64 bit integer vs windows sometimes defaulting to 32 bit (those were the first couple of google hits when i searched the error). though i dont know where the seed is generated in the source code though.

@ilan-gold
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@RubenVanEsch Yes, and the issue there is that we're not the ones calling randint. We may be able to hack it. I'll have a look at how the pipeline errors out on our CI to maybe see where the call is coming from.

@ivirshup
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ivirshup commented Apr 3, 2024

If the problem is windows, it's possible it will be solved by numpy 2.0. Not sure how easy the upgrade path to numpy 2.0 will be, however.

@ilan-gold
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I got the test runner to do windows and while there were other errors, this one was seemingly not present: https://dev.azure.com/scverse/scanpy/_build/results?buildId=6287&view=logs&j=4eb20215-89fc-58e4-6218-2c2fa88ddf72&t=482e4b16-75d9-5f8c-9594-aadcd098d2cb&l=3977

We have a test that is strikingly similar to the more minimal example from above: https://github.com/scverse/scanpy/blob/main/scanpy/tests/notebooks/test_pbmc3k.py minus the umap. Could you try this test (which doesn't call umap) and also try it with umap so it's exactly as our little demo and let us know what you get? We also set resolution in the test. This test seems to actually pass on our CI.

In general there will be some back and forth here until we find someone near us with a windows machine since using CI to fix this problem isn't really feasible, but at least we can narrow the scope.

@ivirshup
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ivirshup commented Apr 4, 2024

@RubenVanEsch, are you able to run this in WSL? Also, does the number you pass for random seed matter?

@ilan-gold
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ilan-gold commented Apr 5, 2024

Also, does the number you pass for random seed matter?

From @RubenVanEsch :

EDIT: the random state does not seem to matter btw, also happens with different random states

@RubenVanEsch
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@ivirshup @ilan-gold just got back to this, thought i could not install wsl as I am on a somewhat company restricted laptop, but turns out i can. installing it now (and probably using that from here on out). will run the tester in a bit and let you know

@ivirshup
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ivirshup commented Apr 5, 2024

import scanpy as sc

em_adata = sc.datasets.pbmc3k()

sc.pp.pca(em_adata, n_comps=50)
sc.pp.neighbors(em_adata)
sc.tl.umap(em_adata)
sc.tl.leiden(em_adata,flavor='igraph',n_iterations=2,random_state=1653,directed=False)

@melonora, would you mind running this on your windows machine with the latest scanpy release to see if you can reproduce it?

@melonora
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melonora commented Apr 5, 2024

Yes I will and report back. Most likely in the evening.

@melonora
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melonora commented Apr 6, 2024

I can reproduce, this is the error that I get:
afbeelding

From a first glance it seems like the default for randint is used which is int32. I can check whether switching to int64 fixes the issue.

@melonora
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melonora commented Apr 6, 2024

I will see if I can reproduce on main and pinpoint where the problem arises.

@RubenVanEsch
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Do you guys still want me to try and run the test from @ilan-gold ? Or is it fine now that it is reproduced on your side as well?

@melonora
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melonora commented Apr 8, 2024

It is reproduced. It is due to the randint producing a value outside the range of the default dtype int32. On windows 64 bit systems the default is int32 despite the system being 64 bit. This is due to default for c long being int32 on these systems.

The part of the code that fails due to this is when using the context manager to perform the leiden clustering with igraph flavor.

@melonora
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melonora commented Apr 8, 2024

In particular here is the piece of code:

with _utils.set_igraph_random_state(random_state):
part = g.community_leiden(**clustering_args)

Though the randint is called from within c code within igraph itself. @ivirshup, do you think asking for calling with dtype int64 would be a problem until this part is fixed on the numpy side?

@ivirshup
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ivirshup commented Apr 8, 2024

Where would you put the dtype=int64 argument?

@melonora
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melonora commented Apr 8, 2024

It wouldn't be on our side. As far as I know the numpy random number generator is called from within c code within igraph itself.

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