diff --git a/bindgen-cli/options.rs b/bindgen-cli/options.rs
index 5c3960e92b..3e4b3f224c 100644
--- a/bindgen-cli/options.rs
+++ b/bindgen-cli/options.rs
@@ -568,6 +568,12 @@ where
             Arg::new("merge-extern-blocks")
                 .long("merge-extern-blocks")
                 .help("Deduplicates extern blocks."),
+            Arg::new("remove-alias")
+                .long("remove-alias")
+                .help("Remove type aliases matching <regex>.")
+                .value_name("regex")
+                .multiple_occurrences(true)
+                .number_of_values(1),
             Arg::new("V")
                 .long("version")
                 .help("Prints the version, and exits"),
@@ -1088,5 +1094,11 @@ where
         builder = builder.merge_extern_blocks(true);
     }
 
+    if let Some(remove_alias) = matches.values_of("remove-alias") {
+        for regex in remove_alias {
+            builder = builder.remove_alias(regex);
+        }
+    }
+
     Ok((builder, output, verbose))
 }
diff --git a/bindgen-tests/tests/expectations/tests/remove_alias.rs b/bindgen-tests/tests/expectations/tests/remove_alias.rs
new file mode 100644
index 0000000000..bae0fd07f3
--- /dev/null
+++ b/bindgen-tests/tests/expectations/tests/remove_alias.rs
@@ -0,0 +1,51 @@
+#![allow(
+    dead_code,
+    non_snake_case,
+    non_camel_case_types,
+    non_upper_case_globals
+)]
+
+pub type i32_ = ::std::os::raw::c_int;
+#[repr(C)]
+#[derive(Debug, Default, Copy, Clone)]
+pub struct int32_ {
+    pub inner: ::std::os::raw::c_int,
+}
+#[test]
+fn bindgen_test_layout_int32_() {
+    const UNINIT: ::std::mem::MaybeUninit<int32_> =
+        ::std::mem::MaybeUninit::uninit();
+    let ptr = UNINIT.as_ptr();
+    assert_eq!(
+        ::std::mem::size_of::<int32_>(),
+        4usize,
+        concat!("Size of: ", stringify!(int32_))
+    );
+    assert_eq!(
+        ::std::mem::align_of::<int32_>(),
+        4usize,
+        concat!("Alignment of ", stringify!(int32_))
+    );
+    assert_eq!(
+        unsafe { ::std::ptr::addr_of!((*ptr).inner) as usize - ptr as usize },
+        0usize,
+        concat!(
+            "Offset of field: ",
+            stringify!(int32_),
+            "::",
+            stringify!(inner)
+        )
+    );
+}
+extern "C" {
+    pub fn foo() -> ::std::os::raw::c_longlong;
+}
+extern "C" {
+    pub fn bar() -> ::std::os::raw::c_int;
+}
+extern "C" {
+    pub fn baz() -> i32_;
+}
+extern "C" {
+    pub fn qux() -> int32_;
+}
diff --git a/bindgen-tests/tests/expectations/tests/remove_template_alias.rs b/bindgen-tests/tests/expectations/tests/remove_template_alias.rs
new file mode 100644
index 0000000000..e06ffadab3
--- /dev/null
+++ b/bindgen-tests/tests/expectations/tests/remove_template_alias.rs
@@ -0,0 +1,8 @@
+#![allow(
+    dead_code,
+    non_snake_case,
+    non_camel_case_types,
+    non_upper_case_globals
+)]
+
+pub type Wrapped<T> = T;
diff --git a/bindgen-tests/tests/headers/remove_alias.h b/bindgen-tests/tests/headers/remove_alias.h
new file mode 100644
index 0000000000..1b83396c25
--- /dev/null
+++ b/bindgen-tests/tests/headers/remove_alias.h
@@ -0,0 +1,14 @@
+// bindgen-flags: --remove-alias "int.*"
+
+typedef long long int64;
+typedef int int32;
+typedef int32 i32;
+
+struct int32_ {
+    int32 inner;
+};
+
+int64 foo();
+int32 bar();
+i32 baz();
+struct int32_ qux();
diff --git a/bindgen-tests/tests/headers/remove_template_alias.hpp b/bindgen-tests/tests/headers/remove_template_alias.hpp
new file mode 100644
index 0000000000..a77021f726
--- /dev/null
+++ b/bindgen-tests/tests/headers/remove_template_alias.hpp
@@ -0,0 +1,4 @@
+// bindgen-flags: --remove-alias "Wrapped"
+
+template<typename T>
+using Wrapped = T;
diff --git a/bindgen/Cargo.toml b/bindgen/Cargo.toml
index dca779bd0c..3965ad4d4c 100644
--- a/bindgen/Cargo.toml
+++ b/bindgen/Cargo.toml
@@ -45,7 +45,7 @@ lazycell = "1"
 lazy_static = "1"
 peeking_take_while = "0.1.2"
 quote = { version = "1", default-features = false }
-syn = { version = "1.0.99", features = ["full", "extra-traits"]}
+syn = { version = "1.0.99", features = ["full", "extra-traits", "visit-mut"]}
 regex = { version = "1.5", default-features = false , features = ["std", "unicode"] }
 which = { version = "4.2.1", optional = true, default-features = false }
 shlex = "1"
diff --git a/bindgen/codegen/postprocessing/merge_extern_blocks.rs b/bindgen/codegen/postprocessing/merge_extern_blocks.rs
index 2b7614941e..f0bf594271 100644
--- a/bindgen/codegen/postprocessing/merge_extern_blocks.rs
+++ b/bindgen/codegen/postprocessing/merge_extern_blocks.rs
@@ -1,6 +1,11 @@
 use syn::{Item, ItemForeignMod};
 
-pub(super) fn merge_extern_blocks(items: &mut Vec<Item>) {
+use crate::BindgenOptions;
+
+pub(super) fn merge_extern_blocks(
+    items: &mut Vec<Item>,
+    _options: &BindgenOptions,
+) {
     // Keep all the extern blocks in a different `Vec` for faster search.
     let mut foreign_mods = Vec::<ItemForeignMod>::new();
 
diff --git a/bindgen/codegen/postprocessing/mod.rs b/bindgen/codegen/postprocessing/mod.rs
index c6612f2b91..6969c7bfc7 100644
--- a/bindgen/codegen/postprocessing/mod.rs
+++ b/bindgen/codegen/postprocessing/mod.rs
@@ -5,14 +5,16 @@ use syn::Item;
 use crate::BindgenOptions;
 
 mod merge_extern_blocks;
+mod remove_alias;
 mod sort_semantically;
 
 use merge_extern_blocks::merge_extern_blocks;
+use remove_alias::remove_alias;
 use sort_semantically::sort_semantically;
 
 struct PostProcessingPass {
     should_run: fn(&BindgenOptions) -> bool,
-    run: fn(&mut Vec<Item>),
+    run: fn(&mut Vec<Item>, &BindgenOptions),
 }
 
 // TODO: This can be a const fn when mutable references are allowed in const
@@ -21,13 +23,19 @@ macro_rules! pass {
     ($pass:ident) => {
         PostProcessingPass {
             should_run: |options| options.$pass,
-            run: |items| $pass(items),
+            run: |items, options| $pass(items, options),
         }
     };
 }
 
-const PASSES: &[PostProcessingPass] =
-    &[pass!(merge_extern_blocks), pass!(sort_semantically)];
+const PASSES: &[PostProcessingPass] = &[
+    pass!(merge_extern_blocks),
+    pass!(sort_semantically),
+    PostProcessingPass {
+        should_run: |options| !options.remove_alias.is_empty(),
+        run: |items, options| remove_alias(items, options),
+    },
+];
 
 pub(crate) fn postprocessing(
     items: Vec<TokenStream>,
@@ -56,7 +64,7 @@ pub(crate) fn postprocessing(
 
     for pass in PASSES {
         if (pass.should_run)(options) {
-            (pass.run)(&mut items);
+            (pass.run)(&mut items, options);
         }
     }
 
diff --git a/bindgen/codegen/postprocessing/remove_alias.rs b/bindgen/codegen/postprocessing/remove_alias.rs
new file mode 100644
index 0000000000..9312527e75
--- /dev/null
+++ b/bindgen/codegen/postprocessing/remove_alias.rs
@@ -0,0 +1,53 @@
+use syn::visit_mut::{visit_type_mut, VisitMut};
+use syn::{Item, Type};
+
+use crate::BindgenOptions;
+
+pub(super) fn remove_alias(items: &mut Vec<Item>, options: &BindgenOptions) {
+    let visitors: Vec<_> = items
+        .iter()
+        .enumerate()
+        .rev()
+        .filter_map(|(index, item)| {
+            if let Item::Type(alias_item) = item {
+                if alias_item.generics.params.is_empty() {
+                    let ident = alias_item.ident.to_string();
+                    if options.remove_alias.matches(&ident) {
+                        return Some((
+                            index,
+                            Visitor {
+                                ident,
+                                ty: alias_item.ty.clone(),
+                            },
+                        ));
+                    }
+                }
+            }
+            None
+        })
+        .collect();
+
+    for (index, mut visitor) in visitors {
+        items.remove(index);
+        for item in items.iter_mut() {
+            visitor.visit_item_mut(item);
+        }
+    }
+}
+
+struct Visitor {
+    ident: String,
+    ty: Box<Type>,
+}
+
+impl VisitMut for Visitor {
+    fn visit_type_mut(&mut self, ty: &mut Type) {
+        if let Type::Path(type_path) = ty {
+            if type_path.path.is_ident(&self.ident) {
+                *ty = self.ty.as_ref().clone();
+            }
+        }
+
+        visit_type_mut::<_>(self, ty)
+    }
+}
diff --git a/bindgen/codegen/postprocessing/sort_semantically.rs b/bindgen/codegen/postprocessing/sort_semantically.rs
index 96596cb01e..019c7ad478 100644
--- a/bindgen/codegen/postprocessing/sort_semantically.rs
+++ b/bindgen/codegen/postprocessing/sort_semantically.rs
@@ -1,6 +1,8 @@
 use syn::Item;
 
-pub(super) fn sort_semantically(items: &mut [Item]) {
+use crate::BindgenOptions;
+
+pub(super) fn sort_semantically(items: &mut [Item], _options: &BindgenOptions) {
     items.sort_by_key(|item| match item {
         Item::Type(_) => 0,
         Item::Struct(_) => 1,
diff --git a/bindgen/lib.rs b/bindgen/lib.rs
index 6e6fa225d6..878a6935b6 100644
--- a/bindgen/lib.rs
+++ b/bindgen/lib.rs
@@ -358,6 +358,7 @@ impl Builder {
             (&self.options.no_default_types, "--no-default"),
             (&self.options.no_hash_types, "--no-hash"),
             (&self.options.must_use_types, "--must-use-type"),
+            (&self.options.remove_alias, "--remove-alias"),
         ];
 
         for (set, flag) in regex_sets {
@@ -1770,6 +1771,13 @@ impl Builder {
         self.options.c_naming = doit;
         self
     }
+
+    /// Remove a type alias that matches the provided argument. Regular
+    /// expressions are supported.
+    pub fn remove_alias<T: Into<String>>(mut self, arg: T) -> Self {
+        self.options.remove_alias.insert(arg.into());
+        self
+    }
 }
 
 /// Configuration options for generated bindings.
@@ -2105,6 +2113,9 @@ struct BindgenOptions {
 
     /// Deduplicate `extern` blocks.
     merge_extern_blocks: bool,
+
+    /// The set of type aliases that should be removed.
+    remove_alias: RegexSet,
 }
 
 /// TODO(emilio): This is sort of a lie (see the error message that results from
@@ -2142,6 +2153,7 @@ impl BindgenOptions {
             &mut self.no_default_types,
             &mut self.no_hash_types,
             &mut self.must_use_types,
+            &mut self.remove_alias,
         ];
         let record_matches = self.record_matches;
         for regex_set in &mut regex_sets {
@@ -2261,6 +2273,7 @@ impl Default for BindgenOptions {
             vtable_generation: false,
             sort_semantically: false,
             merge_extern_blocks: false,
+            remove_alias: Default::default(),
         }
     }
 }