diff --git a/src/ast/nodes/Literal.ts b/src/ast/nodes/Literal.ts
index 5259ada5ef2..97bab48e2bf 100644
--- a/src/ast/nodes/Literal.ts
+++ b/src/ast/nodes/Literal.ts
@@ -70,6 +70,13 @@ export default class Literal<T extends LiteralValue = LiteralValue> extends Node
 				return true;
 			}
 			case INTERACTION_CALLED: {
+				if (
+					this.included &&
+					this.value instanceof RegExp &&
+					(this.value.global || this.value.sticky)
+				) {
+					return true;
+				}
 				return (
 					path.length !== 1 ||
 					hasMemberEffectWhenCalled(this.members, path[0], interaction, context)
diff --git a/src/ast/values.ts b/src/ast/values.ts
index 4d91b067f99..3a479a29136 100644
--- a/src/ast/values.ts
+++ b/src/ast/values.ts
@@ -200,6 +200,11 @@ const literalNumberMembers: MemberDescriptions = assembleMemberDescriptions(
 	objectMembers
 );
 
+/**
+ * RegExp are stateful when they have the global or sticky flags set.
+ * But if we actually don't use them, the side effect does not matter.
+ * the check logic in `hasEffectsOnInteractionAtPath`.
+ */
 const literalRegExpMembers: MemberDescriptions = assembleMemberDescriptions(
 	{
 		exec: returnsUnknown,
diff --git a/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_config.js b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_config.js
new file mode 100644
index 00000000000..6001c39d55d
--- /dev/null
+++ b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_config.js
@@ -0,0 +1,3 @@
+module.exports = {
+	description: 'check tree-shake on RegExp if it is used'
+};
diff --git a/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_expected.js b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_expected.js
new file mode 100644
index 00000000000..72a94a069d1
--- /dev/null
+++ b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/_expected.js
@@ -0,0 +1,23 @@
+const commonRegexp_1 = /1/;
+const commonRegexp_2 = /1/;
+
+assert.strictEqual(commonRegexp_1.test('1'), true);
+assert.ok(commonRegexp_2.exec('1'));
+
+const globalRegexp_1 = /1/g;
+const globalRegexp_2 = /1/g;
+
+globalRegexp_1.test('1');
+globalRegexp_2.exec('1');
+
+assert.strictEqual(globalRegexp_1.test('1'), null);
+assert.strictEqual(globalRegexp_2.exec('1'), null);
+
+const stickyRegexp_1 = /1/y;
+const stickyRegexp_2 = /1/y;
+
+stickyRegexp_1.test('1');
+stickyRegexp_2.exec('1');
+
+assert.strictEqual(stickyRegexp_1.test('1'), null);
+assert.strictEqual(stickyRegexp_2.exec('1'), null);
diff --git a/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/main.js b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/main.js
new file mode 100644
index 00000000000..4124af7072d
--- /dev/null
+++ b/test/form/samples/builtin-prototypes/check-tree-shake-on-regexp-if-it-is-used/main.js
@@ -0,0 +1,26 @@
+const commonRegexp_1 = /1/;
+const commonRegexp_2 = /1/;
+
+commonRegexp_1.test('1');
+commonRegexp_2.exec('1');
+
+assert.strictEqual(commonRegexp_1.test('1'), true);
+assert.ok(commonRegexp_2.exec('1'));
+
+const globalRegexp_1 = /1/g;
+const globalRegexp_2 = /1/g;
+
+globalRegexp_1.test('1');
+globalRegexp_2.exec('1');
+
+assert.strictEqual(globalRegexp_1.test('1'), null);
+assert.strictEqual(globalRegexp_2.exec('1'), null);
+
+const stickyRegexp_1 = /1/y;
+const stickyRegexp_2 = /1/y;
+
+stickyRegexp_1.test('1');
+stickyRegexp_2.exec('1');
+
+assert.strictEqual(stickyRegexp_1.test('1'), null);
+assert.strictEqual(stickyRegexp_2.exec('1'), null);
diff --git a/test/form/samples/builtin-prototypes/literal/main.js b/test/form/samples/builtin-prototypes/literal/main.js
index e079316f4d7..cb99661a2ed 100644
--- a/test/form/samples/builtin-prototypes/literal/main.js
+++ b/test/form/samples/builtin-prototypes/literal/main.js
@@ -49,8 +49,12 @@ const _numberIsPrototypeOf = (1).isPrototypeOf(1).valueOf();
 const _numberPropertyIsEnumerable = (1).propertyIsEnumerable('toString').valueOf();
 
 // RegExp prototype
-/1/.test(2);
-/1/.exec(1);
+/1/.test('1');
+/1/.exec('1');
+/1/y.test('1');
+/1/y.exec('1');
+/1/g.test('1');
+/1/g.exec('1');
 
 // string prototype
 'ab'.valueOf();