diff --git a/mypy/checkpattern.py b/mypy/checkpattern.py
index a23be464b825..1ef2cdd5d6f0 100644
--- a/mypy/checkpattern.py
+++ b/mypy/checkpattern.py
@@ -302,24 +302,42 @@ def visit_sequence_pattern(self, o: SequencePattern) -> PatternType:
         new_type: Type
         rest_type: Type = current_type
         if isinstance(current_type, TupleType) and unpack_index is None:
-            narrowed_inner_types = []
-            inner_rest_types = []
-            for inner_type, new_inner_type in zip(inner_types, new_inner_types):
-                (narrowed_inner_type, inner_rest_type) = (
-                    self.chk.conditional_types_with_intersection(
-                        new_inner_type, [get_type_range(inner_type)], o, default=new_inner_type
-                    )
-                )
-                narrowed_inner_types.append(narrowed_inner_type)
-                inner_rest_types.append(inner_rest_type)
-            if all(not is_uninhabited(typ) for typ in narrowed_inner_types):
-                new_type = TupleType(narrowed_inner_types, current_type.partial_fallback)
+            if all(not is_uninhabited(typ) for typ in new_inner_types):
+                new_type = TupleType(new_inner_types, current_type.partial_fallback)
             else:
                 new_type = UninhabitedType()
 
-            if all(is_uninhabited(typ) for typ in inner_rest_types):
-                # All subpatterns always match, so we can apply negative narrowing
-                rest_type = TupleType(rest_inner_types, current_type.partial_fallback)
+            if all(is_uninhabited(typ) for typ in rest_inner_types):
+                # If all types are uninhabited there is no other pattern that can
+                # match this tuple
+                rest_type = UninhabitedType()
+            elif any(is_uninhabited(typ) for typ in rest_inner_types):
+                # If at least one rest type is uninhabited the rest type can be narrowed
+                narrowed_types: list[Type] = []
+                for inner_type, rest_type in zip(inner_types, rest_inner_types):
+                    # if the narrowed rest type is Uninhabited that means that that the next
+                    # pattern could match any of the original inner types of the tuple.
+                    if is_uninhabited(rest_type):
+                        narrowed_types.append(inner_type)
+                    else:
+                        narrowed_types.append(rest_type)
+                rest_type = TupleType(narrowed_types, current_type.partial_fallback)
+            elif len(rest_inner_types) == 1:
+                # Otherwise we need can apply negative narrowing if the alternative type
+                # is totally disjoint from the pattern narrowed type. And there is only
+                # one field in the tuple.
+                narrowed_inner_types = []
+                inner_rest_types = []
+                for inner_type, new_inner_type in zip(inner_types, new_inner_types):
+                    (narrowed_inner_type, inner_rest_type) = (
+                        self.chk.conditional_types_with_intersection(
+                            new_inner_type, [get_type_range(inner_type)], o, default=new_inner_type
+                        )
+                    )
+                    narrowed_inner_types.append(narrowed_inner_type)
+                    inner_rest_types.append(inner_rest_type)
+                if all(is_uninhabited(typ) for typ in inner_rest_types):
+                    rest_type = TupleType(rest_inner_types, current_type.partial_fallback)
         elif isinstance(current_type, TupleType):
             # For variadic tuples it is too tricky to match individual items like for fixed
             # tuples, so we instead try to narrow the entire type.
diff --git a/test-data/unit/check-python310.test b/test-data/unit/check-python310.test
index 2b56d2db07a9..e50618b65285 100644
--- a/test-data/unit/check-python310.test
+++ b/test-data/unit/check-python310.test
@@ -407,6 +407,66 @@ match m, (n, o):
         pass
 [builtins fixtures/tuple.pyi]
 
+[case testPartialMatchTuplePatternNarrowsUnion]
+from typing import Tuple, Union
+
+m: Tuple[Union[int, None], Union[int, None]]
+
+match m:
+    case a, None:
+        reveal_type(a) # N: Revealed type is "Union[builtins.int, None]"
+        reveal_type(m) # N: Revealed type is "Tuple[Union[builtins.int, None], None]"
+    case None, b:
+        reveal_type(b) # N: Revealed type is "builtins.int"
+        reveal_type(m) # N: Revealed type is "Tuple[None, builtins.int]"
+    case t:
+        reveal_type(t) # N: Revealed type is "Tuple[builtins.int, builtins.int]"
+[builtins fixtures/tuple.pyi]
+
+[case testPartialMatchTuplePatternNarrowsUnionWithFullMatch]
+from typing import Tuple, Union
+
+m: Tuple[Union[int, None], Union[int, None]]
+
+match m:
+    case None, None:
+        reveal_type(m) # N: Revealed type is "Tuple[None, None]"
+    case a, None:
+        reveal_type(a) # N: Revealed type is "Union[builtins.int, None]"
+        reveal_type(m) # N: Revealed type is "Tuple[Union[builtins.int, None], None]"
+    case None, b:
+        reveal_type(b) # N: Revealed type is "builtins.int"
+        reveal_type(m) # N: Revealed type is "Tuple[None, builtins.int]"
+    case t:
+        reveal_type(t) # N: Revealed type is "Tuple[builtins.int, builtins.int]"
+[builtins fixtures/tuple.pyi]
+
+[case testPartialMatchTuplePatternNarrowsUnionWithUninhibitedMatch]
+from typing import Tuple, Union
+
+m: Tuple[Union[int, None], Union[int, None]]
+
+match m:
+    case a, b:
+        reveal_type(m) # N: Revealed type is "Tuple[Union[builtins.int, None], Union[builtins.int, None]]"
+    case t:
+        reveal_type(t)
+[builtins fixtures/tuple.pyi]
+
+[case testMatchTuplePatterNarrowsWithOrMatch]
+from typing import Tuple, Union
+
+m: Tuple[Union[int, None], Union[int, None]]
+
+match m:
+    case (None, _) | (_, None):
+        reveal_type(m) # N: Revealed type is "Union[Tuple[None, Union[builtins.int, None]], Tuple[builtins.int, None]]"
+    case a, b:
+        reveal_type(a) # N: Revealed type is "builtins.int"
+        reveal_type(b) # N: Revealed type is "builtins.int"
+[builtins fixtures/tuple.pyi]
+
+
 -- Mapping Pattern --
 
 [case testMatchMappingPatternCaptures]