diff --git a/telegram/request/_requestparameter.py b/telegram/request/_requestparameter.py
index e7b931e480e..aa14770b827 100644
--- a/telegram/request/_requestparameter.py
+++ b/telegram/request/_requestparameter.py
@@ -20,7 +20,7 @@
 import json
 from dataclasses import dataclass
 from datetime import datetime
-from typing import List, Optional, Tuple
+from typing import List, Optional, Sequence, Tuple
 
 from telegram._files.inputfile import InputFile
 from telegram._files.inputmedia import InputMedia
@@ -143,7 +143,7 @@ def from_input(cls, key: str, value: object) -> "RequestParameter":
         """Builds an instance of this class for a given key-value pair that represents the raw
         input as passed along from a method of :class:`telegram.Bot`.
         """
-        if isinstance(value, list):
+        if not isinstance(value, str) and isinstance(value, Sequence):
             param_values = []
             input_files = []
             for obj in value: