diff --git a/Tests/images/tiff_strip_cmyk_16l_jpeg.tif b/Tests/images/tiff_strip_cmyk_16l_jpeg.tif
new file mode 100644
index 00000000000..8bfd8bd6a89
Binary files /dev/null and b/Tests/images/tiff_strip_cmyk_16l_jpeg.tif differ
diff --git a/Tests/test_file_libtiff.py b/Tests/test_file_libtiff.py
index 0292b7733f1..1d30393d4df 100644
--- a/Tests/test_file_libtiff.py
+++ b/Tests/test_file_libtiff.py
@@ -687,6 +687,12 @@ def test_strip_cmyk_jpeg(self):
 
         self.assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
 
+    def test_strip_cmyk_16l_jpeg(self):
+        infile = "Tests/images/tiff_strip_cmyk_16l_jpeg.tif"
+        im = Image.open(infile)
+
+        self.assert_image_similar_tofile(im, "Tests/images/pil_sample_cmyk.jpg", 0.5)
+
     def test_strip_ycbcr_jpeg_2x2_sampling(self):
         infile = "Tests/images/tiff_strip_ycbcr_jpeg_2x2_sampling.tif"
         im = Image.open(infile)
diff --git a/src/PIL/TiffImagePlugin.py b/src/PIL/TiffImagePlugin.py
index 44dde19956c..0056dc7f5da 100644
--- a/src/PIL/TiffImagePlugin.py
+++ b/src/PIL/TiffImagePlugin.py
@@ -263,6 +263,8 @@
     (II, 5, (1,), 1, (8, 8, 8, 8, 8, 8), (0, 0)): ("CMYK", "CMYKXX"),
     (MM, 5, (1,), 1, (8, 8, 8, 8, 8, 8), (0, 0)): ("CMYK", "CMYKXX"),
 
+    (II, 5, (1,), 1, (16, 16, 16, 16), ()): ("CMYK", "CMYK;16L"),
+
     # JPEG compressed images handled by LibTiff and auto-converted to RGBX
     # Minimal Baseline TIFF requires YCbCr images to have 3 SamplesPerPixel
     (II, 6, (1,), 1, (8, 8, 8), ()): ("RGB", "RGBX"),
diff --git a/src/libImaging/Unpack.c b/src/libImaging/Unpack.c
index 2e29b20f417..d9a948b3246 100644
--- a/src/libImaging/Unpack.c
+++ b/src/libImaging/Unpack.c
@@ -1417,6 +1417,7 @@ static struct {
     {"CMYK",    "CMYKXX",       48,     copy4skip2},
     {"CMYK",    "CMYK;I",       32,     unpackCMYKI},
     {"CMYK",    "CMYK;L",       32,     unpackRGBAL},
+    {"CMYK",    "CMYK;16L",     64,     unpackRGBA16L},
     {"CMYK",    "C",            8,      band0},
     {"CMYK",    "M",            8,      band1},
     {"CMYK",    "Y",            8,      band2},