diff --git a/docs/changelog/2060.bugfix.rst b/docs/changelog/2060.bugfix.rst
new file mode 100644
index 000000000..dbd54cd7e
--- /dev/null
+++ b/docs/changelog/2060.bugfix.rst
@@ -0,0 +1 @@
+Bump embedded pip and setuptools packages to latest upstream supported (``21.0.1`` and ``52.0.0``) - by :user:`gaborbernat`.
diff --git a/src/virtualenv/seed/wheels/embed/__init__.py b/src/virtualenv/seed/wheels/embed/__init__.py
index 672d67bd1..992c85670 100644
--- a/src/virtualenv/seed/wheels/embed/__init__.py
+++ b/src/virtualenv/seed/wheels/embed/__init__.py
@@ -6,32 +6,32 @@
 BUNDLE_FOLDER = Path(__file__).absolute().parent
 BUNDLE_SUPPORT = {
     "3.10": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
-        "setuptools": "setuptools-51.3.3-py3-none-any.whl",
+        "pip": "pip-21.0.1-py3-none-any.whl",
+        "setuptools": "setuptools-52.0.0-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
     "3.9": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
-        "setuptools": "setuptools-51.3.3-py3-none-any.whl",
+        "pip": "pip-21.0.1-py3-none-any.whl",
+        "setuptools": "setuptools-52.0.0-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
     "3.8": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
-        "setuptools": "setuptools-51.3.3-py3-none-any.whl",
+        "pip": "pip-21.0.1-py3-none-any.whl",
+        "setuptools": "setuptools-52.0.0-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
     "3.7": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
-        "setuptools": "setuptools-51.3.3-py3-none-any.whl",
+        "pip": "pip-21.0.1-py3-none-any.whl",
+        "setuptools": "setuptools-52.0.0-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
     "3.6": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
-        "setuptools": "setuptools-51.3.3-py3-none-any.whl",
+        "pip": "pip-21.0.1-py3-none-any.whl",
+        "setuptools": "setuptools-52.0.0-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
     "3.5": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
+        "pip": "pip-20.3.4-py2.py3-none-any.whl",
         "setuptools": "setuptools-50.3.2-py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
@@ -41,7 +41,7 @@
         "wheel": "wheel-0.33.6-py2.py3-none-any.whl",
     },
     "2.7": {
-        "pip": "pip-20.3.3-py2.py3-none-any.whl",
+        "pip": "pip-20.3.4-py2.py3-none-any.whl",
         "setuptools": "setuptools-44.1.1-py2.py3-none-any.whl",
         "wheel": "wheel-0.36.2-py2.py3-none-any.whl",
     },
diff --git a/src/virtualenv/seed/wheels/embed/pip-20.3.3-py2.py3-none-any.whl b/src/virtualenv/seed/wheels/embed/pip-20.3.4-py2.py3-none-any.whl
similarity index 91%
rename from src/virtualenv/seed/wheels/embed/pip-20.3.3-py2.py3-none-any.whl
rename to src/virtualenv/seed/wheels/embed/pip-20.3.4-py2.py3-none-any.whl
index b753b722f..95de4d7a5 100644
Binary files a/src/virtualenv/seed/wheels/embed/pip-20.3.3-py2.py3-none-any.whl and b/src/virtualenv/seed/wheels/embed/pip-20.3.4-py2.py3-none-any.whl differ
diff --git a/src/virtualenv/seed/wheels/embed/pip-21.0.1-py3-none-any.whl b/src/virtualenv/seed/wheels/embed/pip-21.0.1-py3-none-any.whl
new file mode 100644
index 000000000..6d55137b9
Binary files /dev/null and b/src/virtualenv/seed/wheels/embed/pip-21.0.1-py3-none-any.whl differ
diff --git a/src/virtualenv/seed/wheels/embed/setuptools-51.3.3-py3-none-any.whl b/src/virtualenv/seed/wheels/embed/setuptools-52.0.0-py3-none-any.whl
similarity index 91%
rename from src/virtualenv/seed/wheels/embed/setuptools-51.3.3-py3-none-any.whl
rename to src/virtualenv/seed/wheels/embed/setuptools-52.0.0-py3-none-any.whl
index 0419aa31a..9eb776ecf 100644
Binary files a/src/virtualenv/seed/wheels/embed/setuptools-51.3.3-py3-none-any.whl and b/src/virtualenv/seed/wheels/embed/setuptools-52.0.0-py3-none-any.whl differ