diff --git a/kokoro/macos/prepare_build_macos_rc b/kokoro/macos/prepare_build_macos_rc
index 13b00706756f..9b9b2df7b88c 100755
--- a/kokoro/macos/prepare_build_macos_rc
+++ b/kokoro/macos/prepare_build_macos_rc
@@ -6,6 +6,10 @@ set -eux
 
 export HOMEBREW_PREFIX=$(brew --prefix)
 
+##
+# Remove any pre-existing protobuf installation.
+brew uninstall protobuf
+
 ##
 # Select Xcode version
 
diff --git a/kokoro/release/python/macos/build_artifacts.sh b/kokoro/release/python/macos/build_artifacts.sh
index 75644539fa05..4ab9bb8744bc 100755
--- a/kokoro/release/python/macos/build_artifacts.sh
+++ b/kokoro/release/python/macos/build_artifacts.sh
@@ -2,6 +2,9 @@
 
 set -ex
 
+# Remove any pre-existing protobuf installation.
+brew uninstall protobuf
+
 # change to repo root
 pushd $(dirname $0)/../../../..
 
diff --git a/objectivec/DevTools/full_mac_build.sh b/objectivec/DevTools/full_mac_build.sh
index 9ed5b15b2357..4bf336958696 100755
--- a/objectivec/DevTools/full_mac_build.sh
+++ b/objectivec/DevTools/full_mac_build.sh
@@ -290,7 +290,7 @@ if [[ "${DO_XCODE_IOS_TESTS}" == "yes" ]] ; then
           -disable-concurrent-destination-testing
       )
       ;;
-    11.* | 12.* | 13.*)
+    11.* | 12.* | 13.* | 14.*)
       # Dropped 32bit as Apple doesn't seem support the simulators either.
       XCODEBUILD_TEST_BASE_IOS+=(
           -destination "platform=iOS Simulator,name=iPhone 8,OS=latest" # 64bit
@@ -358,7 +358,7 @@ if [[ "${DO_XCODE_TVOS_TESTS}" == "yes" ]] ; then
         -destination "platform=tvOS Simulator,name=Apple TV 4K,OS=latest"
       )
       ;;
-    13.*)
+    13.* | 14.*)
       XCODEBUILD_TEST_BASE_TVOS+=(
         -destination "platform=tvOS Simulator,name=Apple TV 4K (2nd generation),OS=latest"
       )
diff --git a/objectivec/Tests/CocoaPods/run_tests.sh b/objectivec/Tests/CocoaPods/run_tests.sh
index 4f65042bca7d..dfc0aa47d3c9 100755
--- a/objectivec/Tests/CocoaPods/run_tests.sh
+++ b/objectivec/Tests/CocoaPods/run_tests.sh
@@ -128,7 +128,7 @@ do_test() {
     # errors.
     xcodebuild_args+=(
         -sdk iphonesimulator ONLY_ACTIVE_ARCH=NO
-        -destination "platform=iOS Simulator,name=iPad Air (5th generation),OS=15.4"
+        -destination "platform=iOS Simulator,name=iPad Air (5th generation),OS=16.0"
     )
   fi