diff --git a/lib/selector.js b/lib/selector.js
index 123f38f96..2b8f68c25 100644
--- a/lib/selector.js
+++ b/lib/selector.js
@@ -1,3 +1,5 @@
+let { list } = require('postcss')
+
 let OldSelector = require('./old-selector')
 let Prefixer = require('./prefixer')
 let Browsers = require('./browsers')
@@ -53,15 +55,30 @@ class Selector extends Prefixer {
      */
   prefixeds (rule) {
     if (rule._autoprefixerPrefixeds) {
-      return rule._autoprefixerPrefixeds
+      if (rule._autoprefixerPrefixeds[this.name]) {
+        return rule._autoprefixerPrefixeds
+      }
+    } else {
+      rule._autoprefixerPrefixeds = {}
     }
 
     let prefixeds = {}
-    for (let prefix of this.possible()) {
-      prefixeds[prefix] = this.replace(rule.selector, prefix)
+    if (rule.selector.includes(',')) {
+      let ruleParts = list.comma(rule.selector)
+      let toProcess = ruleParts.filter(el => el.includes(this.name))
+
+      for (let prefix of this.possible()) {
+        prefixeds[prefix] = toProcess
+          .map(el => this.replace(el, prefix))
+          .join(', ')
+      }
+    } else {
+      for (let prefix of this.possible()) {
+        prefixeds[prefix] = this.replace(rule.selector, prefix)
+      }
     }
 
-    rule._autoprefixerPrefixeds = prefixeds
+    rule._autoprefixerPrefixeds[this.name] = prefixeds
     return rule._autoprefixerPrefixeds
   }
 
@@ -79,8 +96,8 @@ class Selector extends Prefixer {
       }
 
       let some = false
-      for (let key in prefixeds) {
-        let prefixed = prefixeds[key]
+      for (let key in prefixeds[this.name]) {
+        let prefixed = prefixeds[this.name][key]
         if (before.selector === prefixed) {
           if (prefix === key) {
             return true
@@ -117,7 +134,7 @@ class Selector extends Prefixer {
       return
     }
 
-    let cloned = this.clone(rule, { selector: prefixeds[prefix] })
+    let cloned = this.clone(rule, { selector: prefixeds[this.name][prefix] })
     rule.parent.insertBefore(rule, cloned)
   }
 
diff --git a/test/autoprefixer.test.js b/test/autoprefixer.test.js
index f05096ac0..ee677ea96 100644
--- a/test/autoprefixer.test.js
+++ b/test/autoprefixer.test.js
@@ -44,6 +44,10 @@ let uncascader = autoprefixer({
 let gradienter = autoprefixer({
   overrideBrowserslist: ['Chrome 25', 'Opera 12', 'Android 2.3']
 })
+let grouping = autoprefixer({
+  overrideBrowserslist: ['Chrome 25', 'Firefox > 17', 'IE 10', 'Edge 12'],
+  grid: 'autoplace'
+})
 let ffgradienter = autoprefixer({
   overrideBrowserslist: ['Chrome 25', 'Opera 12', 'Firefox 6']
 })
@@ -90,6 +94,8 @@ function prefixer (name) {
     return gradienter
   } else if (name === 'gradient-fix') {
     return ffgradienter
+  } else if (name === 'grouping-rule') {
+    return grouping
   } else if (name === 'flexbox' || name === 'flex-rewrite') {
     return flexboxer
   } else if (name === 'double') {
@@ -244,6 +250,7 @@ it('saves declaration style', () => check('style'))
 it('uses ignore next control comments', () => check('ignore-next'))
 it('uses block control comments', () => check('disabled'))
 it('has actual example in docs', () => check('example'))
+it('process grouping rules correctly', () => check('grouping-rule'))
 
 it('uses control comments to whole scope', () => {
   let input = read('scope')
diff --git a/test/cases/grouping-rule.css b/test/cases/grouping-rule.css
new file mode 100644
index 000000000..0a59e477f
--- /dev/null
+++ b/test/cases/grouping-rule.css
@@ -0,0 +1,23 @@
+.grid {
+  display: grid;
+}
+
+.a,
+.b,
+.c::selection,
+.d:read-only,
+.e::placeholder {
+  color: yellow;
+}
+
+::selection {
+  color: red;
+}
+
+:read-only {
+  color: black;
+}
+
+.f:read-write, .g:read-write {
+  background: #fff;
+}
diff --git a/test/cases/grouping-rule.out.css b/test/cases/grouping-rule.out.css
new file mode 100644
index 000000000..829872bc1
--- /dev/null
+++ b/test/cases/grouping-rule.out.css
@@ -0,0 +1,64 @@
+.grid {
+  display: -ms-grid;
+  display: grid;
+}
+
+.c::-moz-selection {
+  color: yellow;
+}
+
+.e::-webkit-input-placeholder {
+  color: yellow;
+}
+
+.e:-moz-placeholder {
+  color: yellow;
+}
+
+.e::-moz-placeholder {
+  color: yellow;
+}
+
+.e:-ms-input-placeholder {
+  color: yellow;
+}
+
+.e::-ms-input-placeholder {
+  color: yellow;
+}
+
+.d:-moz-read-only {
+  color: yellow;
+}
+
+.a,
+.b,
+.c::selection,
+.d:read-only,
+.e::placeholder {
+  color: yellow;
+}
+
+::-moz-selection {
+  color: red;
+}
+
+::selection {
+  color: red;
+}
+
+:-moz-read-only {
+  color: black;
+}
+
+:read-only {
+  color: black;
+}
+
+.f:-moz-read-write, .g:-moz-read-write {
+  background: #fff;
+}
+
+.f:read-write, .g:read-write {
+  background: #fff;
+}
diff --git a/test/selector.test.js b/test/selector.test.js
index de590fd9d..afe4109b9 100644
--- a/test/selector.test.js
+++ b/test/selector.test.js
@@ -28,7 +28,7 @@ describe('regexp()', () => {
 })
 
 describe('check()', () => {
-  it('shecks rule selectors', () => {
+  it('checks rule selectors', () => {
     let css = parse('body .selection {}, ' +
             ':::selection {}, body ::selection {}')
     expect(selector.check(css.nodes[0])).toBeFalsy()
@@ -38,13 +38,36 @@ describe('check()', () => {
 })
 
 describe('prefixeds()', () => {
-  it('returns all avaiable prefixed selectors', () => {
+  it('grouping rule gets correct _autoprefixerPrefixeds property', () => {
+    let css = parse('.c::selection, .d:read-only {}')
+    let rSel = new Selector(':read-only', ['-moz-'])
+    selector.prefixeds(css.first)
+    rSel.prefixeds(css.first)
+    expect(css.first._autoprefixerPrefixeds).toEqual({
+      '::selection': {
+        '-webkit-': '.c::-webkit-selection',
+        '-moz-': '.c::-moz-selection',
+        '-ms-': '.c::-ms-selection',
+        '-o-': '.c::-o-selection'
+      },
+      ':read-only': {
+        '-webkit-': '.d:-webkit-read-only',
+        '-moz-': '.d:-moz-read-only',
+        '-ms-': '.d:-ms-read-only',
+        '-o-': '.d:-o-read-only'
+      }
+    })
+  })
+
+  it('returns all available prefixed selectors', () => {
     let css = parse('::selection {}')
     expect(selector.prefixeds(css.first)).toEqual({
-      '-webkit-': '::-webkit-selection',
-      '-moz-': '::-moz-selection',
-      '-ms-': '::-ms-selection',
-      '-o-': '::-o-selection'
+      '::selection': {
+        '-webkit-': '::-webkit-selection',
+        '-moz-': '::-moz-selection',
+        '-ms-': '::-ms-selection',
+        '-o-': '::-o-selection'
+      }
     })
   })
 })