diff --git a/bin/cassandra.in.sh b/bin/cassandra.in.sh
index cb955d7e67..070a7e3a56 100755
--- a/bin/cassandra.in.sh
+++ b/bin/cassandra.in.sh
@@ -99,6 +99,10 @@ JAVA_OPTS="$JAVA_OPTS:-Djava.library.path=$CASSANDRA_HOME/lib/sigar-bin"
 CASSANDRA_TEMP_DIR=$SERVICE_HOME/var/data/tmp
 JVM_OPTS="${JVM_OPTS} -Djava.io.tmpdir=$CASSANDRA_TEMP_DIR"
 JVM_OPTS="${JVM_OPTS} -Djna.tmpdir=$CASSANDRA_TEMP_DIR"
+# See https://access.redhat.com/solutions/6991416
+# https://davecturner.github.io/2021/08/30/seven-year-old-segfault.html
+export LIBFFI_TMPDIR="$CASSANDRA_TEMP_DIR"
+export TMPDIR="$CASSANDRA_TEMP_DIR"
 
 # parse the jvm options files and add them to JVM_OPTS
 JVM_OPTS_FILE=$CASSANDRA_CONF/jvm${jvmoptions_variant:--clients}.options
diff --git a/build.xml b/build.xml
index ec2b029909..94733eb318 100644
--- a/build.xml
+++ b/build.xml
@@ -416,7 +416,7 @@
             <exclusion groupId="hsqldb" artifactId="hsqldb"/> <!-- outdated version -->
             <exclusion groupId="antlr" artifactId="antlr"/> <!-- outdated version -->
           </dependency>
-          <dependency groupId="net.java.dev.jna" artifactId="jna" version="4.0.0"/>
+          <dependency groupId="net.java.dev.jna" artifactId="jna" version="5.13.0"/>
 
           <dependency groupId="net.sourceforge.cobertura" artifactId="cobertura" version="${cobertura.version}">
             <exclusion groupId="xerces" artifactId="xercesImpl"/>
diff --git a/lib/jna-4.0.0.jar b/lib/jna-4.0.0.jar
deleted file mode 100644
index 9038048dc2..0000000000
Binary files a/lib/jna-4.0.0.jar and /dev/null differ
diff --git a/lib/jna-5.13.0.jar b/lib/jna-5.13.0.jar
new file mode 100644
index 0000000000..3d49c81881
Binary files /dev/null and b/lib/jna-5.13.0.jar differ
diff --git a/lib/licenses/jna-4.0.0.txt b/lib/licenses/jna-5.13.0.txt
similarity index 100%
rename from lib/licenses/jna-4.0.0.txt
rename to lib/licenses/jna-5.13.0.txt