Provide an expansion of the abbreviation/acronym, neuronym even, in plain text on first use, use an to mark up the abbreviation, which provides a hint to user agents on how to announce/display the content
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<abbr>FWIW</abbr> (For what it's worth) I often get the following confused: <abbr>WTF</abbr> and <abbr>FTW</abbr>.
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By providing a plain text expansion besides the acronyms, myself and probably others, are less confused by the jargon. Thus improving usability and <abbr>a11y</abbr> (accessibility).
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