diff --git a/numpy/core/src/umath/loops_unary_fp.dispatch.c.src b/numpy/core/src/umath/loops_unary_fp.dispatch.c.src
index 3a1ea82f946..2d5917282c2 100644
--- a/numpy/core/src/umath/loops_unary_fp.dispatch.c.src
+++ b/numpy/core/src/umath/loops_unary_fp.dispatch.c.src
@@ -77,6 +77,56 @@ NPY_FINLINE double c_square_f64(double a)
  */
 #define CONTIG  0
 #define NCONTIG 1
+
+/*
+ * clang has a bug that's present at -O1 or greater.  When partially loading a
+ * vector register for a reciprocal operation, the remaining elements are set
+ * to 1 to avoid divide-by-zero.  The partial load is paired with a partial
+ * store after the reciprocal operation.  clang notices that the entire register
+ * is not needed for the store and optimizes out the fill of 1 to the remaining
+ * elements.  This causes either a divide-by-zero or 0/0 with invalid exception
+ * that we were trying to avoid by filling.
+ *
+ * Using a dummy variable marked 'volatile' convinces clang not to ignore
+ * the explicit fill of remaining elements.  If `-ftrapping-math` is
+ * supported, then it'll also avoid the bug.  `-ftrapping-math` is supported
+ * on Apple clang v12+ for x86_64.  It is not currently supported for arm64.
+ * `-ftrapping-math` is set by default of Numpy builds in
+ * numpy/distutils/ccompiler.py.
+ *
+ * Note: Apple clang and clang upstream have different versions that overlap
+ */
+#if defined(__clang__)
+    #if defined(__apple_build_version__)
+    // Apple Clang
+        #if __apple_build_version__ < 12000000
+        // Apple Clang before v12
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 1
+        #elif defined(NPY_CPU_X86) || defined(NPY_CPU_AMD64)
+        // Apple Clang after v12, targeting i386 or x86_64
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 0
+        #else
+        // Apple Clang after v12, not targeting i386 or x86_64
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 1
+        #endif
+    #else
+    // Clang, not Apple Clang
+        #if __clang_major__ < 10
+        // Clang before v10
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 1
+        #elif defined(NPY_CPU_X86) || defined(NPY_CPU_AMD64)
+        // Clang v10+, targeting i386 or x86_64
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 0
+        #else
+        // Clang v10+, not targeting i386 or x86_64
+        #define WORKAROUND_CLANG_RECIPROCAL_BUG 1
+        #endif
+    #endif
+#else
+// Not a Clang compiler
+#define WORKAROUND_CLANG_RECIPROCAL_BUG 0
+#endif
+
 /**begin repeat
  * #TYPE = FLOAT, DOUBLE#
  * #sfx  = f32, f64#
@@ -87,6 +137,7 @@ NPY_FINLINE double c_square_f64(double a)
  * #kind     = sqrt, absolute, square, reciprocal#
  * #intr     = sqrt, abs,      square, recip#
  * #repl_0w1 = 0,    0,        0,      1#
+ * #RECIP_WORKAROUND = 0, 0,   0,      WORKAROUND_CLANG_RECIPROCAL_BUG#
  */
 /**begin repeat2
  * #STYPE  = CONTIG, NCONTIG, CONTIG,  NCONTIG#
@@ -101,6 +152,8 @@ static void simd_@TYPE@_@kind@_@STYPE@_@DTYPE@
 
     const int vstep = npyv_nlanes_@sfx@;
     const int wstep = vstep * @unroll@;
+
+    // unrolled iterations
     for (; len >= wstep; len -= wstep, src += ssrc*wstep, dst += sdst*wstep) {
         /**begin repeat3
          * #N  = 0, 1, 2, 3#
@@ -126,7 +179,24 @@ static void simd_@TYPE@_@kind@_@STYPE@_@DTYPE@
         #endif
         /**end repeat3**/
     }
-    for (; len > 0; len -= vstep, src += ssrc*vstep, dst += sdst*vstep) {
+
+    // vector-sized iterations
+    for (; len >= vstep; len -= vstep, src += ssrc*vstep, dst += sdst*vstep) {
+    #if @STYPE@ == CONTIG
+        npyv_@sfx@ v_src0 = npyv_load_@sfx@(src);
+    #else
+        npyv_@sfx@ v_src0 = npyv_loadn_@sfx@(src, ssrc);
+    #endif
+        npyv_@sfx@ v_unary0 = npyv_@intr@_@sfx@(v_src0);
+    #if @DTYPE@ == CONTIG
+        npyv_store_@sfx@(dst, v_unary0);
+    #else
+        npyv_storen_@sfx@(dst, sdst, v_unary0);
+    #endif
+    }
+
+    // last partial iteration, if needed
+    if(len > 0){
     #if @STYPE@ == CONTIG
         #if @repl_0w1@
             npyv_@sfx@ v_src0 = npyv_load_till_@sfx@(src, len, 1);
@@ -140,6 +210,15 @@ static void simd_@TYPE@_@kind@_@STYPE@_@DTYPE@
             npyv_@sfx@ v_src0 = npyv_loadn_tillz_@sfx@(src, ssrc, len);
         #endif
     #endif
+        #if @RECIP_WORKAROUND@
+            /*
+             * Workaround clang bug.  We use a dummy variable marked 'volatile'
+             * to convince clang that the entire vector is needed.  We only
+             * want to do this for the last iteration / partial load-store of
+             * the loop since 'volatile' forces a refresh of the contents.
+             */
+             volatile npyv_@sfx@ unused_but_workaround_bug = v_src0;
+        #endif // @RECIP_WORKAROUND@
         npyv_@sfx@ v_unary0 = npyv_@intr@_@sfx@(v_src0);
     #if @DTYPE@ == CONTIG
         npyv_store_till_@sfx@(dst, len, v_unary0);
@@ -147,6 +226,7 @@ static void simd_@TYPE@_@kind@_@STYPE@_@DTYPE@
         npyv_storen_till_@sfx@(dst, sdst, len, v_unary0);
     #endif
     }
+
     npyv_cleanup();
 }
 /**end repeat2**/
@@ -154,6 +234,8 @@ static void simd_@TYPE@_@kind@_@STYPE@_@DTYPE@
 #endif // @VCHK@
 /**end repeat**/
 
+#undef WORKAROUND_CLANG_RECIPROCAL_BUG
+
 /********************************************************************************
  ** Defining ufunc inner functions
  ********************************************************************************/