diff --git a/numpy/typing/_array_like.py b/numpy/typing/_array_like.py
index 9f57b22956cc..cfd9aacb4927 100644
--- a/numpy/typing/_array_like.py
+++ b/numpy/typing/_array_like.py
@@ -77,7 +77,7 @@ def __array__(self) -> ndarray[Any, _DType_co]: ...
 ArrayLike = Union[
     _RecursiveSequence,
     _ArrayLike[
-        "dtype[Any]",
+        dtype,
         Union[bool, int, float, complex, str, bytes]
     ],
 ]
diff --git a/numpy/typing/_dtype_like.py b/numpy/typing/_dtype_like.py
index a41e2f358d97..636e2209b45f 100644
--- a/numpy/typing/_dtype_like.py
+++ b/numpy/typing/_dtype_like.py
@@ -1,5 +1,15 @@
 import sys
-from typing import Any, List, Sequence, Tuple, Union, Type, TypeVar, TYPE_CHECKING
+from typing import (
+    Any,
+    List,
+    Sequence,
+    Tuple,
+    Union,
+    Type,
+    TypeVar,
+    Generic,
+    TYPE_CHECKING,
+)
 
 import numpy as np
 from ._shape import _ShapeLike
@@ -81,7 +91,9 @@ def dtype(self) -> _DType_co: ...
 
 else:
     _DTypeDict = Any
-    _SupportsDType = Any
+
+    class _SupportsDType(Generic[_DType_co]):
+        pass
 
 
 # Would create a dtype[np.void]
@@ -112,7 +124,7 @@ def dtype(self) -> _DType_co: ...
     # array-scalar types and generic types
     type,  # TODO: enumerate these when we add type hints for numpy scalars
     # anything with a dtype attribute
-    "_SupportsDType[np.dtype[Any]]",
+    _SupportsDType[np.dtype],
     # character codes, type strings or comma-separated fields, e.g., 'float64'
     str,
     _VoidDTypeLike,
diff --git a/numpy/typing/tests/test_runtime.py b/numpy/typing/tests/test_runtime.py
new file mode 100644
index 000000000000..e82b08ac26a0
--- /dev/null
+++ b/numpy/typing/tests/test_runtime.py
@@ -0,0 +1,90 @@
+"""Test the runtime usage of `numpy.typing`."""
+
+from __future__ import annotations
+
+import sys
+from typing import get_type_hints, Union, Tuple, NamedTuple
+
+import pytest
+import numpy as np
+import numpy.typing as npt
+
+try:
+    from typing_extensions import get_args, get_origin
+    SKIP = False
+except ImportError:
+    SKIP = True
+
+
+class TypeTup(NamedTuple):
+    typ: type
+    args: Tuple[type, ...]
+    origin: None | type
+
+
+if sys.version_info >= (3, 9):
+    NDArrayTup = TypeTup(npt.NDArray, npt.NDArray.__args__, np.ndarray)
+else:
+    NDArrayTup = TypeTup(npt.NDArray, (), None)
+
+TYPES = {
+    "ArrayLike": TypeTup(npt.ArrayLike, npt.ArrayLike.__args__, Union),
+    "DTypeLike": TypeTup(npt.DTypeLike, npt.DTypeLike.__args__, Union),
+    "NBitBase": TypeTup(npt.NBitBase, (), None),
+    "NDArray": NDArrayTup,
+}
+
+
+@pytest.mark.parametrize("name,tup", TYPES.items(), ids=TYPES.keys())
+@pytest.mark.skipif(SKIP, reason="requires typing-extensions")
+def test_get_args(name: type, tup: TypeTup) -> None:
+    """Test `typing.get_args`."""
+    typ, ref = tup.typ, tup.args
+    out = get_args(typ)
+    assert out == ref
+
+
+@pytest.mark.parametrize("name,tup", TYPES.items(), ids=TYPES.keys())
+@pytest.mark.skipif(SKIP, reason="requires typing-extensions")
+def test_get_origin(name: type, tup: TypeTup) -> None:
+    """Test `typing.get_origin`."""
+    typ, ref = tup.typ, tup.origin
+    out = get_origin(typ)
+    assert out == ref
+
+
+@pytest.mark.parametrize("name,tup", TYPES.items(), ids=TYPES.keys())
+def test_get_type_hints(name: type, tup: TypeTup) -> None:
+    """Test `typing.get_type_hints`."""
+    typ = tup.typ
+
+    # Explicitly set `__annotations__` in order to circumvent the
+    # stringification performed by `from __future__ import annotations`
+    def func(a): pass
+    func.__annotations__ = {"a": typ, "return": None}
+
+    out = get_type_hints(func)
+    ref = {"a": typ, "return": type(None)}
+    assert out == ref
+
+
+@pytest.mark.parametrize("name,tup", TYPES.items(), ids=TYPES.keys())
+def test_get_type_hints_str(name: type, tup: TypeTup) -> None:
+    """Test `typing.get_type_hints` with string-representation of types."""
+    typ_str, typ = f"npt.{name}", tup.typ
+
+    # Explicitly set `__annotations__` in order to circumvent the
+    # stringification performed by `from __future__ import annotations`
+    def func(a): pass
+    func.__annotations__ = {"a": typ_str, "return": None}
+
+    out = get_type_hints(func)
+    ref = {"a": typ, "return": type(None)}
+    assert out == ref
+
+
+def test_keys() -> None:
+    """Test that ``TYPES.keys()`` and ``numpy.typing.__all__`` are synced."""
+    keys = TYPES.keys()
+    ref = set(npt.__all__)
+    assert keys == ref