diff --git a/src/body.js b/src/body.js
index f1233034d..6304cfa8b 100644
--- a/src/body.js
+++ b/src/body.js
@@ -14,6 +14,7 @@ import {FetchError} from './errors/fetch-error.js';
 import {FetchBaseError} from './errors/base.js';
 import {formDataIterator, getBoundary, getFormDataLength} from './utils/form-data.js';
 import {isBlob, isURLSearchParameters, isFormData} from './utils/is.js';
+import {blobToNodeStream} from './utils/blob-to-stream.js';
 
 const INTERNALS = Symbol('Body internals');
 
@@ -177,7 +178,7 @@ async function consumeBody(data) {
 
 	// Body is blob
 	if (isBlob(body)) {
-		body = body.stream();
+		body = blobToNodeStream(body);
 	}
 
 	// Body is buffer
@@ -371,7 +372,7 @@ export const writeToStream = (dest, {body}) => {
 		dest.end();
 	} else if (isBlob(body)) {
 		// Body is Blob
-		body.stream().pipe(dest);
+		blobToNodeStream(body).pipe(dest);
 	} else if (Buffer.isBuffer(body)) {
 		// Body is buffer
 		dest.write(body);
diff --git a/src/utils/blob-to-stream.js b/src/utils/blob-to-stream.js
new file mode 100644
index 000000000..824956252
--- /dev/null
+++ b/src/utils/blob-to-stream.js
@@ -0,0 +1,23 @@
+import {Readable} from 'stream';
+
+// 64 KiB (same size chrome slice theirs blob into Uint8array's)
+const POOL_SIZE = 65536;
+
+/* c8 ignore start */
+async function * read(blob) {
+	let position = 0;
+	while (position !== blob.size) {
+		const chunk = blob.slice(position, Math.min(blob.size, position + POOL_SIZE));
+		// eslint-disable-next-line no-await-in-loop
+		const buffer = await chunk.arrayBuffer();
+		position += buffer.byteLength;
+		yield new Uint8Array(buffer);
+	}
+}
+/* c8 ignore end */
+
+export function blobToNodeStream(blob) {
+	return Readable.from(blob.stream ? blob.stream() : read(blob), {
+		objectMode: false
+	});
+}
diff --git a/src/utils/is.js b/src/utils/is.js
index fa8d15922..f690b3c58 100644
--- a/src/utils/is.js
+++ b/src/utils/is.js
@@ -38,9 +38,13 @@ export const isBlob = object => {
 		typeof object === 'object' &&
 		typeof object.arrayBuffer === 'function' &&
 		typeof object.type === 'string' &&
-		typeof object.stream === 'function' &&
+		// typeof object.stream === 'function' &&
 		typeof object.constructor === 'function' &&
-		/^(Blob|File)$/.test(object[NAME])
+		(
+			/* c8 ignore next 2 */
+			/^(Blob|File)$/.test(object[NAME]) ||
+			/^(Blob|File)$/.test(object.constructor.name)
+		)
 	);
 };
 
diff --git a/test/response.js b/test/response.js
index f02b67f4d..cd4753974 100644
--- a/test/response.js
+++ b/test/response.js
@@ -3,6 +3,7 @@ import * as stream from 'stream';
 import {TextEncoder} from 'util';
 import chai from 'chai';
 import Blob from 'fetch-blob';
+import buffer from 'buffer';
 import {Response} from '../src/index.js';
 import TestServer from './utils/server.js';
 
@@ -173,6 +174,15 @@ describe('Response', () => {
 		});
 	});
 
+	if (buffer.Blob) {
+		it('should support Buffer.Blob as body', () => {
+			const res = new Response(new buffer.Blob(['a=1']));
+			return res.text().then(result => {
+				expect(result).to.equal('a=1');
+			});
+		});
+	}
+
 	it('should support Uint8Array as body', () => {
 		const encoder = new TextEncoder();
 		const res = new Response(encoder.encode('a=1'));