diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 6287eaadf..b1fec8c8b 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -42,7 +42,7 @@ jobs:
         ]
         include:
           # Test minimal supported Rust version
-          - rust: 1.39.0
+          - rust: 1.41.1
             python-version: 3.8
             platform: { os: "ubuntu-latest", python-architecture: "x64", rust-target: "x86_64-unknown-linux-gnu" }
             msrv: "MSRV"
diff --git a/Cargo.lock b/Cargo.lock
index 613eb7502..08c537600 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -337,16 +337,16 @@ dependencies = [
 
 [[package]]
 name = "numpy"
-version = "0.12.2"
+version = "0.13.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9fd9e8e652becf4ba6c11803945f8bf463c23f482f704bb33f70ae9d22482d10"
+checksum = "a7073fae1e0b82409533a29c6f804b79783d7b2d3c07728fdc4d884eda8cd4f0"
 dependencies = [
  "cfg-if 0.1.10",
  "libc",
  "ndarray",
  "num-complex",
  "num-traits",
- "pyo3 0.12.4",
+ "pyo3",
 ]
 
 [[package]]
@@ -424,22 +424,6 @@ dependencies = [
  "unicode-xid",
 ]
 
-[[package]]
-name = "pyo3"
-version = "0.12.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bf6bbbe8f70d179260b3728e5d04eb012f4f0c7988e58c11433dd689cecaa72e"
-dependencies = [
- "ctor",
- "indoc",
- "inventory",
- "libc",
- "parking_lot",
- "paste",
- "pyo3cls",
- "unindent",
-]
-
 [[package]]
 name = "pyo3"
 version = "0.13.2"
@@ -458,17 +442,6 @@ dependencies = [
  "unindent",
 ]
 
-[[package]]
-name = "pyo3-derive-backend"
-version = "0.12.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "10ecd0eb6ed7b3d9965b4f4370b5b9e99e3e5e8742000e1c452c018f8c2a322f"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn",
-]
-
 [[package]]
 name = "pyo3-macros"
 version = "0.13.2"
@@ -491,17 +464,6 @@ dependencies = [
  "syn",
 ]
 
-[[package]]
-name = "pyo3cls"
-version = "0.12.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d344fdaa6a834a06dd1720ff104ea12fe101dad2e8db89345af9db74c0bb11a0"
-dependencies = [
- "pyo3-derive-backend",
- "quote",
- "syn",
-]
-
 [[package]]
 name = "quote"
 version = "1.0.9"
@@ -609,7 +571,7 @@ dependencies = [
  "ndarray",
  "numpy",
  "petgraph",
- "pyo3 0.13.2",
+ "pyo3",
  "rand",
  "rand_pcg",
  "rayon",
diff --git a/Cargo.toml b/Cargo.toml
index 7dab14d74..6fc95354a 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -19,7 +19,7 @@ crate-type = ["cdylib"]
 [dependencies]
 petgraph = "0.5.1"
 fixedbitset = "0.2.0"
-numpy = "0.12.1"
+numpy = "0.13.1"
 rand = "0.8"
 rand_pcg = "0.3"
 rayon = "1.5"
diff --git a/README.md b/README.md
index 9eb9613d6..cc2a13333 100644
--- a/README.md
+++ b/README.md
@@ -5,7 +5,7 @@
 [![](https://img.shields.io/github/release/Qiskit/retworkx.svg?style=popout-square)](https://github.com/Qiskit/retworkx/releases)
 [![](https://img.shields.io/pypi/dm/retworkx.svg?style=popout-square)](https://pypi.org/project/retworkx/)
 [![Coverage Status](https://coveralls.io/repos/github/Qiskit/retworkx/badge.svg?branch=master)](https://coveralls.io/github/Qiskit/retworkx?branch=master)
-[![Minimum rustc 1.39](https://img.shields.io/badge/rustc-1.39+-blue.svg)](https://rust-lang.github.io/rfcs/2495-min-rust-version.html)
+[![Minimum rustc 1.41.1](https://img.shields.io/badge/rustc-1.41.19+-blue.svg)](https://rust-lang.github.io/rfcs/2495-min-rust-version.html)
 
   - You can see the full rendered docs at:
     <https://retworkx.readthedocs.io/en/latest/index.html>
@@ -37,7 +37,7 @@ environment.
 
 If there are no precompiled binaries published for your system you'll have to
 build the package from source. However, to be able able to build the package
-from the published source package you need to have rust >=1.39 installed (and
+from the published source package you need to have rust >=1.41.1 installed (and
 also [cargo](https://doc.rust-lang.org/cargo/) which is normally included with
 rust) You can use [rustup](https://rustup.rs/) (a cross platform installer for
 rust) to make this simpler, or rely on