diff --git a/src/cmap/connection.ts b/src/cmap/connection.ts
index 7aa913fbe4..4d5fb74935 100644
--- a/src/cmap/connection.ts
+++ b/src/cmap/connection.ts
@@ -384,7 +384,7 @@ export class Connection extends TypedEventEmitter<ConnectionEvents> {
       } else {
         // Get the first orphaned operation description.
         const entry = this[kQueue].entries().next();
-        if (entry) {
+        if (entry.value !== undefined) {
           const [requestId, orphaned]: [number, OperationDescription] = entry.value;
           // If the orphaned operation description exists then set it.
           operationDescription = orphaned;
diff --git a/test/unit/cmap/connection.test.ts b/test/unit/cmap/connection.test.ts
index a9b95bcea2..cb516858b3 100644
--- a/test/unit/cmap/connection.test.ts
+++ b/test/unit/cmap/connection.test.ts
@@ -287,6 +287,34 @@ describe('new Connection()', function () {
         });
       });
 
+      context('when no operation description is in the queue', function () {
+        const document = { ok: 1 };
+
+        beforeEach(function () {
+          // @ts-expect-error: driverSocket does not fully satisfy the stream type, but that's okay
+          connection = sinon.spy(new Connection(driverSocket, connectionOptionsDefaults));
+          connection.isMonitoringConnection = true;
+          const queueSymbol = getSymbolFrom(connection, 'queue');
+          queue = connection[queueSymbol];
+
+          // Emit a message that matches the existing operation description.
+          const msg = generateOpMsgBuffer(document);
+          const msgHeader: MessageHeader = {
+            length: msg.readInt32LE(0),
+            requestId: 2,
+            responseTo: 1,
+            opCode: msg.readInt32LE(12)
+          };
+          const msgBody = msg.subarray(16);
+
+          const message = new BinMsg(msg, msgHeader, msgBody);
+          connection.onMessage(message);
+        });
+
+        it('does not error', function () {
+        });
+      });
+
       context('when more than one operation description is in the queue', function () {
         let spyOne;
         let spyTwo;