diff --git a/.flake8 b/.flake8
new file mode 100644
index 0000000000..564a578cf1
--- /dev/null
+++ b/.flake8
@@ -0,0 +1,3 @@
+[flake8]
+max-line-length = 119
+extend-ignore = E203
diff --git a/.github/workflows/deploy-release.yml b/.github/workflows/deploy-release.yml
index b8ea99519f..053986ddee 100644
--- a/.github/workflows/deploy-release.yml
+++ b/.github/workflows/deploy-release.yml
@@ -14,20 +14,20 @@ jobs:
       - name: Setup Python
         uses: actions/setup-python@v2
         with:
-          python-version: 3.7
+          python-version: 3.9
       - name: Install dependencies
         run: |
-          python -m pip install --upgrade pip setuptools wheel babel
+          python -m pip install -U hatch babel
       - name: Compile localization message files
         run: |
           pybabel compile --statistics --directory mkdocs/themes/mkdocs/locales
           pybabel compile --statistics --directory mkdocs/themes/readthedocs/locales
       - name: Build
         run: |
-          python setup.py bdist_wheel sdist --formats gztar
+          hatch build
       - name: Publish
-        if: success()
-        uses: pypa/gh-action-pypi-publish@v1.4.1
-        with:
-          user: __token__
-          password: ${{ secrets.PYPI_PASSWORD }}
+        run: |
+          hatch publish
+        env:
+          HATCH_INDEX_USER: __token__
+          HATCH_INDEX_AUTH: ${{ secrets.PYPI_PASSWORD }}
diff --git a/MANIFEST.in b/MANIFEST.in
deleted file mode 100644
index 032a060c09..0000000000
--- a/MANIFEST.in
+++ /dev/null
@@ -1,5 +0,0 @@
-include README.md
-include LICENSE
-recursive-include mkdocs *.ico *.js *.css *.png *.html *.eot *.svg *.ttf *.woff *.woff2 *.xml *.mustache *mkdocs_theme.yml *.mo
-recursive-exclude * __pycache__
-recursive-exclude * *.py[co]
diff --git a/docs/about/contributing.md b/docs/about/contributing.md
index 3f09efed85..8d21e43476 100644
--- a/docs/about/contributing.md
+++ b/docs/about/contributing.md
@@ -90,7 +90,7 @@ updated by running the `extract_messages` command. For example, to update the
 `pot` file of the `mkdocs` theme, run the following command:
 
 ```bash
-pybabel extract --project=MkDocs --copyright-holder=MkDocs --msgid-bugs-address='https://github.com/mkdocs/mkdocs/issues' --no-wrap --version="$(grep -Eo "\\b[123][^']+" mkdocs/__init__.py)" --mapping-file mkdocs/themes/babel.cfg --output-file mkdocs/themes/mkdocs/messages.pot mkdocs/themes/mkdocs
+pybabel extract --project=MkDocs --copyright-holder=MkDocs --msgid-bugs-address='https://github.com/mkdocs/mkdocs/issues' --no-wrap --version="$(hatch version)" --mapping-file mkdocs/themes/babel.cfg --output-file mkdocs/themes/mkdocs/messages.pot mkdocs/themes/mkdocs
 ```
 
 The updated `pot` file should be included in a PR with the updated template.
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000000..f80be6c62e
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,92 @@
+[build-system]
+requires = ["hatchling"]
+build-backend = "hatchling.build"
+
+[project]
+name = "mkdocs"
+description = "Project documentation with Markdown."
+readme = "README.md"
+license = "BSD-2-Clause"
+authors = [
+    {name = "Tom Christie", email = "tom@tomchristie.com"},
+]
+classifiers = [
+    "Development Status :: 5 - Production/Stable",
+    "Environment :: Console",
+    "Environment :: Web Environment",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: BSD License",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3 :: Only",
+    "Programming Language :: Python :: Implementation :: CPython",
+    "Programming Language :: Python :: Implementation :: PyPy",
+    "Topic :: Documentation",
+    "Topic :: Text Processing",
+]
+dynamic = ["version"]
+requires-python = ">=3.7"
+dependencies = [
+    "click >=7.0",
+    "Jinja2 >=2.11.1",
+    "Markdown >=3.2.1, <3.4",
+    "PyYAML >=5.1",
+    "watchdog >=2.0",
+    "ghp-import >=1.0",
+    "pyyaml_env_tag >=0.1",
+    "importlib_metadata >=4.3; python_version < '3.10'",
+    "typing_extensions >=3.10; python_version < '3.8'",
+    "packaging >=20.5",
+    "mergedeep >=1.3.4",
+    "colorama >=0.4; platform_system == 'Windows'",
+]
+[project.optional-dependencies]
+i18n = [
+    "babel >=2.9.0",
+]
+
+[project.urls]
+Documentation = "https://www.mkdocs.org/"
+Source = "https://github.com/mkdocs/mkdocs"
+Issues = "https://github.com/mkdocs/mkdocs/issues"
+History = "https://www.mkdocs.org/about/release-notes/"
+
+[project.scripts]
+mkdocs = "mkdocs.__main__:cli"
+
+[project.entry-points."mkdocs.themes"]
+mkdocs = "mkdocs.themes.mkdocs"
+readthedocs = "mkdocs.themes.readthedocs"
+
+[project.entry-points."mkdocs.plugins"]
+search = "mkdocs.contrib.search:SearchPlugin"
+
+[tool.hatch.version]
+path = "mkdocs/__init__.py"
+
+[tool.hatch.build]
+artifacts = ["/mkdocs/**/*.mo"]
+[tool.hatch.build.targets.sdist]
+include = ["/mkdocs"]
+[tool.hatch.build.targets.wheel]
+exclude = ["/mkdocs/tests/integration", "*.po", "*.pot", "babel.cfg"]
+
+[tool.black]
+line-length = 100
+target-version = ["py37"]
+skip-string-normalization = true
+
+[tool.isort]
+profile = "black"
+line_length = 100
+
+[tool.mypy]
+ignore_missing_imports = true
+warn_unreachable = true
+no_implicit_optional = true
+show_error_codes = true
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 5aa7537760..0000000000
--- a/setup.cfg
+++ /dev/null
@@ -1,16 +0,0 @@
-[metadata]
-license_files = LICENSE
-
-[flake8]
-max-line-length = 119
-extend-ignore = E203
-
-[isort]
-profile = black
-line_length = 100
-
-[mypy]
-ignore_missing_imports = true
-warn_unreachable = true
-no_implicit_optional = true
-show_error_codes = true
diff --git a/setup.py b/setup.py
old mode 100755
new mode 100644
index b5ef3f05ea..4d5ce0a930
--- a/setup.py
+++ b/setup.py
@@ -1,95 +1,13 @@
-#!/usr/bin/env python
+"""Installation using setup.py is no longer supported.
+Use `python -m pip install .` instead."""
 
-from setuptools import setup
-import re
-import os
 import sys
 
+from setuptools import setup
 
-with open('README.md') as f:
-    long_description = f.read()
-
-
-def get_version(package):
-    """Return package version as listed in `__version__` in `init.py`."""
-    with open(os.path.join(package, '__init__.py')) as f:
-        init_py = f.read()
-    return re.search("__version__ = ['\"]([^'\"]+)['\"]", init_py).group(1)
-
-
-def get_packages(package):
-    """Return root package and all sub-packages."""
-    return [dirpath
-            for dirpath, dirnames, filenames in os.walk(package)
-            if os.path.exists(os.path.join(dirpath, '__init__.py'))]
-
+sys.exit(__doc__)
 
+# Fake reference so GitHub still considers it a real package for statistics purposes.
 setup(
     name="mkdocs",
-    version=get_version("mkdocs"),
-    url='https://www.mkdocs.org',
-    project_urls={
-        'Source': 'https://github.com/mkdocs/mkdocs',
-    },
-    license='BSD',
-    description='Project documentation with Markdown.',
-    long_description=long_description,
-    long_description_content_type='text/markdown',
-    author='Tom Christie',
-    author_email='tom@tomchristie.com',  # SEE NOTE BELOW (*)
-    packages=get_packages("mkdocs"),
-    include_package_data=True,
-    package_data={'mkdocs': ['py.typed']},
-    install_requires=[
-        'click>=7.0',
-        'Jinja2>=2.11.1',
-        'Markdown>=3.2.1,<3.4',
-        'PyYAML>=5.1',
-        'watchdog>=2.0',
-        'ghp-import>=1.0',
-        'pyyaml_env_tag>=0.1',
-        'importlib_metadata>=4.3; python_version < "3.10"',
-        'typing_extensions>=3.10; python_version < "3.8"',
-        'packaging>=20.5',
-        'mergedeep>=1.3.4',
-        'colorama>=0.4; platform_system == "Windows"',
-    ],
-    extras_require={"i18n": ['babel>=2.9.0']},
-    python_requires='>=3.7',
-    entry_points={
-        'console_scripts': [
-            'mkdocs = mkdocs.__main__:cli',
-        ],
-        'mkdocs.themes': [
-            'mkdocs = mkdocs.themes.mkdocs',
-            'readthedocs = mkdocs.themes.readthedocs',
-        ],
-        'mkdocs.plugins': [
-            'search = mkdocs.contrib.search:SearchPlugin',
-        ],
-    },
-    classifiers=[
-        'Development Status :: 5 - Production/Stable',
-        'Environment :: Console',
-        'Environment :: Web Environment',
-        'Intended Audience :: Developers',
-        'License :: OSI Approved :: BSD License',
-        'Operating System :: OS Independent',
-        'Programming Language :: Python',
-        'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.6',
-        'Programming Language :: Python :: 3.7',
-        'Programming Language :: Python :: 3.8',
-        'Programming Language :: Python :: 3.9',
-        'Programming Language :: Python :: 3.10',
-        'Programming Language :: Python :: 3 :: Only',
-        "Programming Language :: Python :: Implementation :: CPython",
-        "Programming Language :: Python :: Implementation :: PyPy",
-        'Topic :: Documentation',
-        'Topic :: Text Processing',
-    ],
-    zip_safe=False,
 )
-
-# (*) Please direct queries to the discussion group:
-#     https://groups.google.com/forum/#!forum/mkdocs
diff --git a/tox.ini b/tox.ini
index bac7c3fbc8..1b181c349d 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,4 +1,5 @@
 [tox]
+isolated_build = true
 envlist =
     py{37,38,39,310,py3}-{unittests,min-req,integration,integration-no-babel},
     black, isort, flake8, markdown-lint, linkchecker, jshint, csslint, nobabel, codespell
@@ -19,7 +20,7 @@ commands=
 [testenv:black]
 deps=black
 skip_install=true
-commands={envbindir}/black -l100 -tpy37 --skip-string-normalization mkdocs
+commands={envbindir}/black mkdocs
 
 [testenv:isort]
 deps=isort