diff --git a/commands/run/__tests__/__fixtures__/powered-by-nx/packages/package-1/package.json b/commands/run/__tests__/__fixtures__/powered-by-nx/packages/package-1/package.json
index b6b638e487..9978bcb211 100644
--- a/commands/run/__tests__/__fixtures__/powered-by-nx/packages/package-1/package.json
+++ b/commands/run/__tests__/__fixtures__/powered-by-nx/packages/package-1/package.json
@@ -3,6 +3,7 @@
   "version": "1.0.0",
   "scripts": {
     "fail": "exit 1",
-    "my-script": "echo package-1"
+    "my-script": "echo package-1",
+    "another-script:but-with-colons": "echo package-1-script-with-colons"
   }
-}
+}
\ No newline at end of file
diff --git a/commands/run/__tests__/run-command.test.js b/commands/run/__tests__/run-command.test.js
index 83dfbecbe6..3e95157577 100644
--- a/commands/run/__tests__/run-command.test.js
+++ b/commands/run/__tests__/run-command.test.js
@@ -331,6 +331,13 @@ describe("RunCommand", () => {
       expect(collectedOutput).toContain("Successfully ran target");
     });
 
+    it("runs a script with a colon in the script name", async () => {
+      collectedOutput = "";
+      await lernaRun(testDir)("another-script:but-with-colons");
+      expect(collectedOutput).toContain("package-1-script-with-colons");
+      expect(collectedOutput).toContain("Successfully ran target");
+    });
+
     it("runs a script only in scoped packages", async () => {
       collectedOutput = "";
       await lernaRun(testDir)("my-script", "--scope", "package-1");
diff --git a/commands/run/index.js b/commands/run/index.js
index 298af74d8f..56dbeb5ed9 100644
--- a/commands/run/index.js
+++ b/commands/run/index.js
@@ -170,6 +170,15 @@ class RunCommand extends Command {
     return chain;
   }
 
+  addQuotesAroundScriptNameIfItHasAColon(scriptName) {
+    // Nx requires quotes around script names of the form script:name
+    if (scriptName.includes(":")) {
+      return `"${scriptName}"`;
+    } else {
+      return scriptName;
+    }
+  }
+
   runScriptsUsingNx() {
     if (this.options.ci) {
       process.env.CI = "true";
@@ -179,7 +188,10 @@ class RunCommand extends Command {
     const { targetDependencies, options } = this.prepNxOptions();
     if (this.packagesWithScript.length === 1) {
       const { runOne } = require("nx/src/command-line/run-one");
-      const fullQualifiedTarget = this.packagesWithScript.map((p) => p.name)[0] + ":" + this.script;
+      const fullQualifiedTarget =
+        this.packagesWithScript.map((p) => p.name)[0] +
+        ":" +
+        this.addQuotesAroundScriptNameIfItHasAColon(this.script);
       return runOne(
         process.cwd(),
         {
diff --git a/e2e/tests/lerna-run/lerna-run.spec.ts b/e2e/tests/lerna-run/lerna-run.spec.ts
index 99c7e5b986..947fc04ea8 100644
--- a/e2e/tests/lerna-run/lerna-run.spec.ts
+++ b/e2e/tests/lerna-run/lerna-run.spec.ts
@@ -310,6 +310,22 @@ describe("useNx", () => {
         "print-name": "echo test-package-3",
       },
     });
+    await fixture.lerna("create package-4 -y");
+    await fixture.addScriptsToPackage({
+      packagePath: "packages/package-4",
+      scripts: {
+        "print:name": "echo test-package-4",
+        "print-name-run-one-only": "echo test-package-4-run-one-only",
+        "print:name:run-one-only": "echo test-package-4-run-one-only-with-colon",
+      },
+    });
+    await fixture.lerna("create package-5 -y");
+    await fixture.addScriptsToPackage({
+      packagePath: "packages/package-5",
+      scripts: {
+        "print:name": "echo test-package-5",
+      },
+    });
   });
   afterAll(() => fixture.destroy());
 
@@ -355,6 +371,92 @@ test-package-X
  >  Lerna (powered by Nx)   Successfully ran target print-name for 3 projects
 
 
+lerna notice cli v999.9.9-e2e.0
+
+`);
+  });
+
+  describe("run one", () => {
+    it("should run script on single child package using nx", async () => {
+      const output = await fixture.lerna(`run print-name-run-one-only`);
+
+      expect(output.combinedOutput).toMatchInlineSnapshot(`
+  
+  > package-X:print-name-run-one-only
+  
+  
+  > package-X@0.0.0 print-name-run-one-only
+  > echo test-package-X-run-one-only
+  
+  test-package-X-run-one-only
+  
+   
+  
+   >  Lerna (powered by Nx)   Successfully ran target print-name-run-one-only for project package-X
+  
+  
+  lerna notice cli v999.9.9-e2e.0
+  
+  `);
+    });
+
+    it("should run script with colon on single child package using nx", async () => {
+      const output = await fixture.lerna(`run print:name:run-one-only`);
+
+      expect(output.combinedOutput).toMatchInlineSnapshot(`
+
+  > package-X:"print:name:run-one-only"
+  
+  
+  > package-X@0.0.0 print:name:run-one-only
+  > echo test-package-X-run-one-only-with-colon
+  
+  test-package-X-run-one-only-with-colon
+  
+   
+  
+   >  Lerna (powered by Nx)   Successfully ran target print:name:run-one-only for project package-X
+  
+  
+  lerna notice cli v999.9.9-e2e.0
+  
+  `);
+    });
+  });
+
+  it("should run script with colon on all child package using nx", async () => {
+    const output = await fixture.lerna(`run print:name`);
+
+    expect(output.combinedOutput).toMatchInlineSnapshot(`
+
+ >  Lerna (powered by Nx)   Running target print:name for 2 project(s):
+
+    - package-X
+    - package-X
+
+ 
+
+> package-X:"print:name"
+
+
+> package-X@0.0.0 print:name
+> echo test-package-X
+
+test-package-X
+
+> package-X:"print:name"
+
+
+> package-X@0.0.0 print:name
+> echo test-package-X
+
+test-package-X
+
+ 
+
+ >  Lerna (powered by Nx)   Successfully ran target print:name for 2 projects
+
+
 lerna notice cli v999.9.9-e2e.0
 
 `);