diff --git a/src/Illuminate/Contracts/Queue/UniqueJob.php b/src/Illuminate/Contracts/Queue/UniqueJob.php
new file mode 100644
index 000000000000..603be95f5d42
--- /dev/null
+++ b/src/Illuminate/Contracts/Queue/UniqueJob.php
@@ -0,0 +1,8 @@
+<?php
+
+namespace Illuminate\Contracts\Queue;
+
+interface UniqueJob
+{
+    //
+}
diff --git a/src/Illuminate/Foundation/Bus/PendingDispatch.php b/src/Illuminate/Foundation/Bus/PendingDispatch.php
index 74e37b269522..98c36b3504b4 100644
--- a/src/Illuminate/Foundation/Bus/PendingDispatch.php
+++ b/src/Illuminate/Foundation/Bus/PendingDispatch.php
@@ -2,7 +2,10 @@
 
 namespace Illuminate\Foundation\Bus;
 
+use Illuminate\Container\Container;
 use Illuminate\Contracts\Bus\Dispatcher;
+use Illuminate\Contracts\Cache\Repository as Cache;
+use Illuminate\Contracts\Queue\UniqueJob;
 
 class PendingDispatch
 {
@@ -121,6 +124,29 @@ public function afterResponse()
         return $this;
     }
 
+    /**
+     * Determine if the job should be dispatched.
+     *
+     * @return bool
+     */
+    protected function shouldDispatch()
+    {
+        if (! ($this->job instanceof UniqueJob)) {
+            return true;
+        }
+
+        $uniqueId = method_exists($this->job, 'uniqueId')
+                    ? $this->job->uniqueId()
+                    : ($this->job->uniqueId ?? '');
+
+        $lock = Container::getInstance()->make(Cache::class)->lock(
+            $key = 'unique:'.get_class($this->job).$uniqueId,
+            $this->job->uniqueFor ?? 0
+        );
+
+        return (bool) $lock->get();
+    }
+
     /**
      * Dynamically proxy methods to the underlying job.
      *
@@ -142,7 +168,9 @@ public function __call($method, $parameters)
      */
     public function __destruct()
     {
-        if ($this->afterResponse) {
+        if (! $this->shouldDispatch()) {
+            // Do nothing.
+        } elseif ($this->afterResponse) {
             app(Dispatcher::class)->dispatchAfterResponse($this->job);
         } else {
             app(Dispatcher::class)->dispatch($this->job);
diff --git a/src/Illuminate/Foundation/Console/stubs/job.queued.stub b/src/Illuminate/Foundation/Console/stubs/job.queued.stub
index 5f0651cb1789..0be12826fb73 100644
--- a/src/Illuminate/Foundation/Console/stubs/job.queued.stub
+++ b/src/Illuminate/Foundation/Console/stubs/job.queued.stub
@@ -4,6 +4,7 @@ namespace {{ namespace }};
 
 use Illuminate\Bus\Queueable;
 use Illuminate\Contracts\Queue\ShouldQueue;
+use Illuminate\Contracts\Queue\UniqueJob;
 use Illuminate\Foundation\Bus\Dispatchable;
 use Illuminate\Queue\InteractsWithQueue;
 use Illuminate\Queue\SerializesModels;
diff --git a/src/Illuminate/Queue/CallQueuedHandler.php b/src/Illuminate/Queue/CallQueuedHandler.php
index 4a9c9e1f20e4..ec3bfa48ea27 100644
--- a/src/Illuminate/Queue/CallQueuedHandler.php
+++ b/src/Illuminate/Queue/CallQueuedHandler.php
@@ -5,8 +5,10 @@
 use Exception;
 use Illuminate\Bus\Batchable;
 use Illuminate\Contracts\Bus\Dispatcher;
+use Illuminate\Contracts\Cache\Repository as Cache;
 use Illuminate\Contracts\Container\Container;
 use Illuminate\Contracts\Queue\Job;
+use Illuminate\Contracts\Queue\UniqueJob;
 use Illuminate\Database\Eloquent\ModelNotFoundException;
 use Illuminate\Pipeline\Pipeline;
 use ReflectionClass;
@@ -59,6 +61,10 @@ public function call(Job $job, array $data)
 
         $this->dispatchThroughMiddleware($job, $command);
 
+        if (! $job->isReleased()) {
+            $this->ensureUniqueJobLockIsReleased($command);
+        }
+
         if (! $job->hasFailed() && ! $job->isReleased()) {
             $this->ensureNextJobInChainIsDispatched($command);
             $this->ensureSuccessfulBatchJobIsRecorded($command);
@@ -153,6 +159,25 @@ protected function ensureSuccessfulBatchJobIsRecorded($command)
         $command->batch()->recordSuccessfulJob($command->job->uuid());
     }
 
+    /**
+     * Ensure the lock for the unique job is released.
+     *
+     * @param  mixed  $command
+     * @return void
+     */
+    protected function ensureUniqueJobLockIsReleased($command)
+    {
+        if ($command instanceof UniqueJob) {
+            $uniqueId = method_exists($command, 'uniqueId')
+                        ? $command->uniqueId()
+                        : ($command->uniqueId ?? '');
+
+            $this->container->make(Cache::class)
+                    ->lock('unique:'.get_class($command).$uniqueId)
+                    ->forceRelease();
+        }
+    }
+
     /**
      * Handle a model not found exception.
      *
@@ -192,6 +217,7 @@ public function failed(array $data, $e, string $uuid)
     {
         $command = unserialize($data['command']);
 
+        $this->ensureUniqueJobLockIsReleased($command);
         $this->ensureFailedBatchJobIsRecorded($uuid, $command, $e);
         $this->ensureChainCatchCallbacksAreInvoked($uuid, $command, $e);
 
diff --git a/tests/Integration/Queue/RateLimitedTest.php b/tests/Integration/Queue/RateLimitedTest.php
index c4f12f6144e0..d73dd58a2c29 100644
--- a/tests/Integration/Queue/RateLimitedTest.php
+++ b/tests/Integration/Queue/RateLimitedTest.php
@@ -88,7 +88,7 @@ protected function assertJobRanSuccessfully($class)
         $job = m::mock(Job::class);
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
-        $job->shouldReceive('isReleased')->once()->andReturn(false);
+        $job->shouldReceive('isReleased')->andReturn(false);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(false);
         $job->shouldReceive('delete')->once();
 
@@ -108,7 +108,7 @@ protected function assertJobWasReleased($class)
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
         $job->shouldReceive('release')->once();
-        $job->shouldReceive('isReleased')->once()->andReturn(true);
+        $job->shouldReceive('isReleased')->andReturn(true);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(true);
 
         $instance->call($job, [
@@ -126,7 +126,7 @@ protected function assertJobWasSkipped($class)
         $job = m::mock(Job::class);
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
-        $job->shouldReceive('isReleased')->once()->andReturn(false);
+        $job->shouldReceive('isReleased')->andReturn(false);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(false);
         $job->shouldReceive('delete')->once();
 
diff --git a/tests/Integration/Queue/RateLimitedWithRedisTest.php b/tests/Integration/Queue/RateLimitedWithRedisTest.php
index 5956fff06180..175f531bbfa0 100644
--- a/tests/Integration/Queue/RateLimitedWithRedisTest.php
+++ b/tests/Integration/Queue/RateLimitedWithRedisTest.php
@@ -119,7 +119,7 @@ protected function assertJobRanSuccessfully($testJob)
         $job = m::mock(Job::class);
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
-        $job->shouldReceive('isReleased')->once()->andReturn(false);
+        $job->shouldReceive('isReleased')->andReturn(false);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(false);
         $job->shouldReceive('delete')->once();
 
@@ -139,7 +139,7 @@ protected function assertJobWasReleased($testJob)
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
         $job->shouldReceive('release')->once();
-        $job->shouldReceive('isReleased')->once()->andReturn(true);
+        $job->shouldReceive('isReleased')->andReturn(true);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(true);
 
         $instance->call($job, [
@@ -157,7 +157,7 @@ protected function assertJobWasSkipped($testJob)
         $job = m::mock(Job::class);
 
         $job->shouldReceive('hasFailed')->once()->andReturn(false);
-        $job->shouldReceive('isReleased')->once()->andReturn(false);
+        $job->shouldReceive('isReleased')->andReturn(false);
         $job->shouldReceive('isDeletedOrReleased')->once()->andReturn(false);
         $job->shouldReceive('delete')->once();
 
diff --git a/tests/Integration/Queue/UniqueJobTest.php b/tests/Integration/Queue/UniqueJobTest.php
new file mode 100644
index 000000000000..45c09338ae40
--- /dev/null
+++ b/tests/Integration/Queue/UniqueJobTest.php
@@ -0,0 +1,196 @@
+<?php
+
+namespace Illuminate\Tests\Integration\Queue;
+
+use Illuminate\Bus\Queueable;
+use Illuminate\Contracts\Cache\Repository as Cache;
+use Illuminate\Contracts\Queue\ShouldQueue;
+use Illuminate\Contracts\Queue\UniqueJob;
+use Illuminate\Database\Schema\Blueprint;
+use Illuminate\Foundation\Bus\Dispatchable;
+use Illuminate\Queue\InteractsWithQueue;
+use Illuminate\Support\Facades\Bus;
+use Mockery as m;
+use Orchestra\Testbench\TestCase;
+
+/**
+ * @group integration
+ */
+class UniqueJobTest extends TestCase
+{
+    protected function getEnvironmentSetUp($app)
+    {
+        $app['config']->set('database.default', 'testbench');
+        $app['config']->set('database.connections.testbench', [
+            'driver' => 'sqlite',
+            'database' => ':memory:',
+            'prefix' => '',
+        ]);
+
+        $app['db']->connection()->getSchemaBuilder()->create('jobs', function (Blueprint $table) {
+            $table->bigIncrements('id');
+            $table->string('queue');
+            $table->longText('payload');
+            $table->tinyInteger('attempts')->unsigned();
+            $table->unsignedInteger('reserved_at')->nullable();
+            $table->unsignedInteger('available_at');
+            $table->unsignedInteger('created_at');
+            $table->index(['queue', 'reserved_at']);
+        });
+    }
+
+    protected function tearDown(): void
+    {
+        $this->app['db']->connection()->getSchemaBuilder()->drop('jobs');
+
+        parent::tearDown();
+
+        m::close();
+    }
+
+    public function testUniqueJobsAreNotDispatched()
+    {
+        Bus::fake();
+        UniqueTestJob::dispatch();
+        Bus::assertDispatched(UniqueTestJob::class);
+
+        $this->assertFalse(
+            $this->app->get(Cache::class)->lock($this->getLockKey(UniqueTestJob::class), 10)->get()
+        );
+
+        Bus::fake();
+        UniqueTestJob::dispatch();
+        Bus::assertNotDispatched(UniqueTestJob::class);
+
+        $this->assertFalse(
+            $this->app->get(Cache::class)->lock($this->getLockKey(UniqueTestJob::class), 10)->get()
+        );
+    }
+
+    public function testLockIsReleasedForSuccessfulJobs()
+    {
+        UniqueTestJob::$handled = false;
+        dispatch($job = new UniqueTestJob);
+
+        $this->assertTrue($job::$handled);
+        $this->assertTrue($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+    }
+
+    public function testLockIsReleasedForFailedJobs()
+    {
+        UniqueTestFailJob::$handled = false;
+
+        $this->expectException(\Exception::class);
+
+        try {
+            dispatch($job = new UniqueTestFailJob);
+        } finally {
+            $this->assertTrue($job::$handled);
+            $this->assertTrue($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+        }
+    }
+
+    public function testLockIsNotReleasedForJobRetries()
+    {
+        UniqueTestRetryJob::$handled = false;
+        dispatch($job = new UniqueTestRetryJob);
+
+        $this->assertFalse($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+
+        $this->artisan('queue:work', [
+            'connection' => 'database',
+            '--once' => true,
+        ]);
+
+        $this->assertTrue($job::$handled);
+        $this->assertFalse($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+
+        UniqueTestRetryJob::$handled = false;
+        $this->artisan('queue:work', [
+            'connection' => 'database',
+            '--once' => true,
+        ]);
+
+        $this->assertTrue($job::$handled);
+        $this->assertTrue($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+    }
+
+    public function testLockIsNotReleasedForJobReleases()
+    {
+        UniqueTestReleasedJob::$handled = false;
+        dispatch($job = new UniqueTestReleasedJob);
+
+        $this->assertFalse($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+
+        $this->artisan('queue:work', [
+            'connection' => 'database',
+            '--once' => true,
+        ]);
+
+        $this->assertTrue($job::$handled);
+        $this->assertFalse($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+
+        UniqueTestReleasedJob::$handled = false;
+        $this->artisan('queue:work', [
+            'connection' => 'database',
+            '--once' => true,
+        ]);
+
+        $this->assertFalse($job::$handled);
+        $this->assertTrue($this->app->get(Cache::class)->lock($this->getLockKey($job), 10)->get());
+    }
+
+    protected function getLockKey($job)
+    {
+        return 'unique:'.(is_string($job) ? $job : get_class($job));
+    }
+}
+
+class UniqueTestJob implements ShouldQueue, UniqueJob
+{
+    use InteractsWithQueue, Queueable, Dispatchable;
+
+    public static $handled = false;
+
+    public function handle()
+    {
+        static::$handled = true;
+    }
+}
+
+class UniqueTestFailJob implements ShouldQueue, UniqueJob
+{
+    use InteractsWithQueue, Queueable, Dispatchable;
+
+    public $tries = 1;
+
+    public static $handled = false;
+
+    public function handle()
+    {
+        static::$handled = true;
+
+        throw new \Exception;
+    }
+}
+
+class UniqueTestReleasedJob extends UniqueTestFailJob
+{
+    public $tries = 1;
+
+    public $connection = 'database';
+
+    public function handle()
+    {
+        static::$handled = true;
+
+        $this->release();
+    }
+}
+
+class UniqueTestRetryJob extends UniqueTestFailJob
+{
+    public $tries = 2;
+
+    public $connection = 'database';
+}