diff --git a/CHANGELOG.md b/CHANGELOG.md
index 45b0f703e4bc..21d59d56382d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -52,6 +52,7 @@
 - `[jest-config]` Support `testTimeout` in project config ([#14697](https://github.com/jestjs/jest/pull/14697))
 - `[jest-config]` Support `coverageReporters` in project config ([#14697](https://github.com/jestjs/jest/pull/14830))
 - `[jest-config]` Allow `reporters` in project config ([#14768](https://github.com/jestjs/jest/pull/14768))
+- `[jest-config]` Allow Node16/NodeNext/Bundler `moduleResolution` in project's tsconfig ([#14739](https://github.com/jestjs/jest/pull/14739))
 - `[jest-each]` Allow `$keypath` templates with `null` or `undefined` values ([#14831](https://github.com/jestjs/jest/pull/14831))
 - `[@jest/expect-utils]` Fix comparison of `DataView` ([#14408](https://github.com/jestjs/jest/pull/14408))
 - `[@jest/expect-utils]` [**BREAKING**] exclude non-enumerable in object matching ([#14670](https://github.com/jestjs/jest/pull/14670))
diff --git a/e2e/__tests__/typescriptConfigFile.test.ts b/e2e/__tests__/typescriptConfigFile.test.ts
index df0e316c5bd3..d857e6bfc1d7 100644
--- a/e2e/__tests__/typescriptConfigFile.test.ts
+++ b/e2e/__tests__/typescriptConfigFile.test.ts
@@ -8,7 +8,7 @@
 import {tmpdir} from 'os';
 import * as path from 'path';
 import {cleanup, writeFiles} from '../Utils';
-import runJest from '../runJest';
+import runJest, {getConfig} from '../runJest';
 
 const DIR = path.resolve(tmpdir(), 'typescript-config-file');
 
@@ -107,3 +107,19 @@ test('works with multiple typescript configs that import something', () => {
   expect(exitCode).toBe(0);
   expect(stdout).toBe('');
 });
+
+test("works with single typescript config that does not import anything with project's moduleResolution set to Node16", () => {
+  const {configs} = getConfig(
+    'typescript-config/modern-module-resolution',
+    [],
+    {
+      skipPkgJsonCheck: true,
+    },
+  );
+
+  expect(configs).toHaveLength(1);
+  expect(configs[0].displayName).toEqual({
+    color: 'white',
+    name: 'Config from modern ts file',
+  });
+});
diff --git a/e2e/typescript-config/modern-module-resolution/__tests__/test.js b/e2e/typescript-config/modern-module-resolution/__tests__/test.js
new file mode 100644
index 000000000000..fc395e3a0f4a
--- /dev/null
+++ b/e2e/typescript-config/modern-module-resolution/__tests__/test.js
@@ -0,0 +1,10 @@
+/**
+ * Copyright (c) Meta Platforms, Inc. and affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+test('dummy test', () => {
+  expect(1).toBe(1);
+});
diff --git a/e2e/typescript-config/modern-module-resolution/jest.config.ts b/e2e/typescript-config/modern-module-resolution/jest.config.ts
new file mode 100644
index 000000000000..995821a204f5
--- /dev/null
+++ b/e2e/typescript-config/modern-module-resolution/jest.config.ts
@@ -0,0 +1,12 @@
+/**
+ * Copyright (c) Meta Platforms, Inc. and affiliates.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+const config = {
+  displayName: 'Config from modern ts file',
+  testEnvironment: 'node',
+};
+export default config;
diff --git a/e2e/typescript-config/modern-module-resolution/package.json b/e2e/typescript-config/modern-module-resolution/package.json
new file mode 100644
index 000000000000..5bbefffbabee
--- /dev/null
+++ b/e2e/typescript-config/modern-module-resolution/package.json
@@ -0,0 +1,3 @@
+{
+  "type": "commonjs"
+}
diff --git a/e2e/typescript-config/modern-module-resolution/tsconfig.json b/e2e/typescript-config/modern-module-resolution/tsconfig.json
new file mode 100644
index 000000000000..bdf27dc03284
--- /dev/null
+++ b/e2e/typescript-config/modern-module-resolution/tsconfig.json
@@ -0,0 +1,8 @@
+{
+  "compilerOptions": {
+    "target": "ESNext",
+    "module": "Node16",
+    "moduleResolution": "Node16",
+    "strict": true
+  }
+}
diff --git a/packages/jest-config/src/readConfigFileAndSetRootDir.ts b/packages/jest-config/src/readConfigFileAndSetRootDir.ts
index 84ec03e6ccc9..01ddb602dd07 100644
--- a/packages/jest-config/src/readConfigFileAndSetRootDir.ts
+++ b/packages/jest-config/src/readConfigFileAndSetRootDir.ts
@@ -119,6 +119,7 @@ async function registerTsNode(): Promise<Service> {
     return tsNode.register({
       compilerOptions: {
         module: 'CommonJS',
+        moduleResolution: 'Node10',
       },
       moduleTypes: {
         '**': 'cjs',