diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8fca48ea0867..2a7d61e3b338 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -50,7 +50,7 @@
 - `[jest-console]` `console.dir` now respects the second argument correctly ([#10638](https://github.com/facebook/jest/pull/10638))
 - `[jest-core]` Don't report PerformanceObserver as open handle ([#11123](https://github.com/facebook/jest/pull/11123))
 - `[jest-core]` Use `WeakRef` to hold timers when detecting open handles ([#11277](https://github.com/facebook/jest/pull/11277))
-- `[jest-core]` Run GC detecting open handles ([#11278](https://github.com/facebook/jest/pull/11278))
+- `[jest-core]` Do not collect `RANDOMBYTESREQUEST` as open handles ([#11278](https://github.com/facebook/jest/pull/11278))
 - `[jest-each]` [**BREAKING**] Ignore excess words in headings ([#8766](https://github.com/facebook/jest/pull/8766))
 - `[jest-environment]` [**BREAKING**] Drop support for `runScript` for test environments ([#11155](https://github.com/facebook/jest/pull/11155))
 - `[jest-environment-jsdom]` Use inner realm’s `ArrayBuffer` constructor ([#10885](https://github.com/facebook/jest/pull/10885))
diff --git a/packages/jest-core/src/collectHandles.ts b/packages/jest-core/src/collectHandles.ts
index 633ba3756ff4..45fd328dab22 100644
--- a/packages/jest-core/src/collectHandles.ts
+++ b/packages/jest-core/src/collectHandles.ts
@@ -8,15 +8,12 @@
 /* eslint-disable local/ban-types-eventually */
 
 import * as asyncHooks from 'async_hooks';
-import {promisify} from 'util';
-import {setFlagsFromString} from 'v8';
-import {runInNewContext} from 'vm';
 import stripAnsi = require('strip-ansi');
 import type {Config} from '@jest/types';
 import {formatExecError} from 'jest-message-util';
 import {ErrorWithStack} from 'jest-util';
 
-export type HandleCollectionResult = () => Promise<Array<Error>>;
+export type HandleCollectionResult = () => Array<Error>;
 
 function stackIsFromUser(stack: string) {
   // Either the test file, or something required by it
@@ -44,21 +41,6 @@ const alwaysActive = () => true;
 
 const hasWeakRef = typeof WeakRef === 'function';
 
-const tick = promisify(setImmediate);
-
-function runGarbageCollector() {
-  const isGarbageCollectorHidden = !global.gc;
-
-  // GC is usually hidden, so we have to expose it before running.
-  setFlagsFromString('--expose-gc');
-  runInNewContext('gc')();
-
-  // The GC was not initially exposed, so let's hide it again.
-  if (isGarbageCollectorHidden) {
-    setFlagsFromString('--no-expose-gc');
-  }
-}
-
 // Inspired by https://github.com/mafintosh/why-is-node-running/blob/master/index.js
 // Extracted as we want to format the result ourselves
 export default function collectHandles(): HandleCollectionResult {
@@ -80,7 +62,8 @@ export default function collectHandles(): HandleCollectionResult {
         type === 'PROMISE' ||
         type === 'TIMERWRAP' ||
         type === 'ELDHISTOGRAM' ||
-        type === 'PerformanceObserver'
+        type === 'PerformanceObserver' ||
+        type === 'RANDOMBYTESREQUEST'
       ) {
         return;
       }
@@ -118,14 +101,7 @@ export default function collectHandles(): HandleCollectionResult {
 
   hook.enable();
 
-  return async () => {
-    runGarbageCollector();
-
-    // wait some ticks to allow GC to run properly, see https://github.com/nodejs/node/issues/34636#issuecomment-669366235
-    for (let i = 0; i < 10; i++) {
-      await tick();
-    }
-
+  return () => {
     hook.disable();
 
     // Get errors for every async resource still referenced at this moment
diff --git a/packages/jest-core/src/runJest.ts b/packages/jest-core/src/runJest.ts
index 9000e6da7b5a..65f191802eac 100644
--- a/packages/jest-core/src/runJest.ts
+++ b/packages/jest-core/src/runJest.ts
@@ -75,7 +75,7 @@ type ProcessResultOptions = Pick<
   outputStream: NodeJS.WriteStream;
 };
 
-const processResults = async (
+const processResults = (
   runResults: AggregatedResult,
   options: ProcessResultOptions,
 ) => {
@@ -89,7 +89,7 @@ const processResults = async (
   } = options;
 
   if (collectHandles) {
-    runResults.openHandles = await collectHandles();
+    runResults.openHandles = collectHandles();
   } else {
     runResults.openHandles = [];
   }
@@ -278,7 +278,7 @@ export default async function runJest({
     await runGlobalHook({allTests, globalConfig, moduleName: 'globalTeardown'});
   }
 
-  await processResults(results, {
+  processResults(results, {
     collectHandles,
     json: globalConfig.json,
     onComplete,