diff --git a/CHANGELOG.md b/CHANGELOG.md
index c622bdf254bf..82fa1f1190a6 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,7 @@
 
 ### Fixes
 
+- `[jest-config]` Add `.pnp.js` to `transformIgnorePatterns` defaults ([#10383](https://github.com/facebook/jest/pull/10383))
 - `[jest-leak-detector]` Wait properly for GC runs due to changes in Node 14.7 ([#10366](https://github.com/facebook/jest/pull/10366))
 - `[jest-worker]` Downgrade minimum node version to 10.13 ([#10352](https://github.com/facebook/jest/pull/10352))
 - `[docs]` Update snapshot testing documentation([#10359](https://github.com/facebook/jest/pull/10359))
diff --git a/docs/Configuration.md b/docs/Configuration.md
index 65d80f43744b..406f48fa493f 100644
--- a/docs/Configuration.md
+++ b/docs/Configuration.md
@@ -1165,7 +1165,7 @@ _Note: when adding additional code transformers, this will overwrite the default
 
 ### `transformIgnorePatterns` [array\<string>]
 
-Default: `["/node_modules/"]`
+Default: `["/node_modules/", "\\.pnp\\.[^\\\/]+$"]`
 
 An array of regexp pattern strings that are matched against all source file paths before transformation. If the test path matches any of the patterns, it will not be transformed.
 
diff --git a/e2e/__tests__/__snapshots__/showConfig.test.ts.snap b/e2e/__tests__/__snapshots__/showConfig.test.ts.snap
index 3f4e045e6cc6..77708ecfc22e 100644
--- a/e2e/__tests__/__snapshots__/showConfig.test.ts.snap
+++ b/e2e/__tests__/__snapshots__/showConfig.test.ts.snap
@@ -72,7 +72,8 @@ exports[`--showConfig outputs config info and exits 1`] = `
         ]
       ],
       "transformIgnorePatterns": [
-        "/node_modules/"
+        "/node_modules/",
+        "<<REPLACED_PNP_PATH>>"
       ],
       "watchPathIgnorePatterns": []
     }
diff --git a/e2e/__tests__/showConfig.test.ts b/e2e/__tests__/showConfig.test.ts
index 44338280551d..0ef9c2a51ef5 100644
--- a/e2e/__tests__/showConfig.test.ts
+++ b/e2e/__tests__/showConfig.test.ts
@@ -31,6 +31,7 @@ test('--showConfig outputs config info and exits', () => {
 
   stdout = stdout
     .replace(/\\\\node_modules\\\\/g, 'node_modules')
+    .replace(/\\\\\.pnp\\\\\.\[\^[/\\]+\]\+\$/g, '<<REPLACED_PNP_PATH>>')
     .replace(/\\\\(?:([^.]+?)|$)/g, '/$1')
     .replace(/"cacheDirectory": "(.+)"/g, '"cacheDirectory": "/tmp/jest"')
     .replace(/"name": "(.+)"/g, '"name": "[md5 hash]"')
diff --git a/packages/jest-cli/src/init/__tests__/__snapshots__/init.test.js.snap b/packages/jest-cli/src/init/__tests__/__snapshots__/init.test.js.snap
index f00ac27eea2f..70e36b545cad 100644
--- a/packages/jest-cli/src/init/__tests__/__snapshots__/init.test.js.snap
+++ b/packages/jest-cli/src/init/__tests__/__snapshots__/init.test.js.snap
@@ -222,7 +222,8 @@ module.exports = {
 
   // An array of regexp pattern strings that are matched against all source file paths, matched files will skip transformation
   // transformIgnorePatterns: [
-  //   \\"/node_modules/\\"
+  //   \\"/node_modules/\\",
+  //   \\"\\\\\\\\.pnp\\\\\\\\.[^\\\\\\\\/]+$\\"
   // ],
 
   // An array of regexp pattern strings that are matched against all modules before the module loader will automatically return a mock for them
diff --git a/packages/jest-config/src/Defaults.ts b/packages/jest-config/src/Defaults.ts
index e86c3174785c..8f496952ea0e 100644
--- a/packages/jest-config/src/Defaults.ts
+++ b/packages/jest-config/src/Defaults.ts
@@ -5,6 +5,7 @@
  * LICENSE file in the root directory of this source tree.
  */
 
+import {sep} from 'path';
 import type {Config} from '@jest/types';
 import {replacePathSepForRegex} from 'jest-regex-util';
 import {NODE_MODULES} from './constants';
@@ -63,7 +64,7 @@ const defaultOptions: Config.DefaultOptions = {
   testSequencer: '@jest/test-sequencer',
   testURL: 'http://localhost',
   timers: 'real',
-  transformIgnorePatterns: [NODE_MODULES_REGEXP],
+  transformIgnorePatterns: [NODE_MODULES_REGEXP, `\\.pnp\\.[^\\${sep}]+$`],
   useStderr: false,
   watch: false,
   watchPathIgnorePatterns: [],