diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7f621f66b734..a56f695b53df 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -48,6 +48,7 @@
 - `[jest-config]` [**BREAKING**] Change default file extension order by moving json behind ts and tsx ([10572](https://github.com/facebook/jest/pull/10572))
 - `[jest-console]` `console.dir` now respects the second argument correctly ([#10638](https://github.com/facebook/jest/pull/10638))
 - `[jest-core]` Don't report PerformanceObserver as open handle ([#11123](https://github.com/facebook/jest/pull/11123))
+- `[jest-core]` Run GC detecting open handles ([#11278](https://github.com/facebook/jest/pull/11278))
 - `[jest-each]` [**BREAKING**] Ignore excess words in headings ([#8766](https://github.com/facebook/jest/pull/8766))
 - `[jest-environment]` [**BREAKING**] Drop support for `runScript` for test environments ([#11155](https://github.com/facebook/jest/pull/11155))
 - `[jest-environment-jsdom]` Use inner realm’s `ArrayBuffer` constructor ([#10885](https://github.com/facebook/jest/pull/10885))
diff --git a/e2e/__tests__/detectOpenHandles.ts b/e2e/__tests__/detectOpenHandles.ts
index 977434965a3f..3a302f752c90 100644
--- a/e2e/__tests__/detectOpenHandles.ts
+++ b/e2e/__tests__/detectOpenHandles.ts
@@ -71,6 +71,17 @@ it('does not report promises', () => {
   expect(textAfterTest).toBe('');
 });
 
+it('does not report crypto random data', () => {
+  // The test here is basically that it exits cleanly without reporting anything (does not need `until`)
+  const {stderr} = runJest('detect-open-handles', [
+    'crypto',
+    '--detectOpenHandles',
+  ]);
+  const textAfterTest = getTextAfterTest(stderr);
+
+  expect(textAfterTest).toBe('');
+});
+
 onNodeVersions('>=11.10.0', () => {
   it('does not report ELD histograms', () => {
     const {stderr} = runJest('detect-open-handles', [
diff --git a/e2e/detect-open-handles/__tests__/crypto.js b/e2e/detect-open-handles/__tests__/crypto.js
new file mode 100644
index 000000000000..1a4284994d8e
--- /dev/null
+++ b/e2e/detect-open-handles/__tests__/crypto.js
@@ -0,0 +1,13 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates. All Rights Reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+const {randomFillSync} = require('crypto');
+
+test('randomFillSync()', () => {
+  const buf = Buffer.alloc(10);
+  randomFillSync(buf);
+});
diff --git a/packages/jest-core/src/cli/index.ts b/packages/jest-core/src/cli/index.ts
index 639b277129ce..8d57af3a0742 100644
--- a/packages/jest-core/src/cli/index.ts
+++ b/packages/jest-core/src/cli/index.ts
@@ -32,7 +32,7 @@ import watch from '../watch';
 
 const {print: preRunMessagePrint} = preRunMessage;
 
-type OnCompleteCallback = (results: AggregatedResult) => void;
+type OnCompleteCallback = (results: AggregatedResult) => void | undefined;
 
 export async function runCLI(
   argv: Config.Argv,
@@ -89,7 +89,9 @@ export async function runCLI(
     configsOfProjectsToRun,
     hasDeprecationWarnings,
     outputStream,
-    r => (results = r),
+    r => {
+      results = r;
+    },
   );
 
   if (argv.watch || argv.watchAll) {
diff --git a/packages/jest-core/src/collectHandles.ts b/packages/jest-core/src/collectHandles.ts
index 13a8181ec3b4..0ea2bd111a0c 100644
--- a/packages/jest-core/src/collectHandles.ts
+++ b/packages/jest-core/src/collectHandles.ts
@@ -8,11 +8,16 @@
 /* eslint-disable local/ban-types-eventually */
 
 import * as asyncHooks from 'async_hooks';
+import {promisify} from 'util';
+import {setFlagsFromString} from 'v8';
+import {runInNewContext} from 'vm';
 import stripAnsi = require('strip-ansi');
 import type {Config} from '@jest/types';
 import {formatExecError} from 'jest-message-util';
 import {ErrorWithStack} from 'jest-util';
 
+export type HandleCollectionResult = () => Promise<Array<Error>>;
+
 function stackIsFromUser(stack: string) {
   // Either the test file, or something required by it
   if (stack.includes('Runtime.requireModule')) {
@@ -37,13 +42,28 @@ function stackIsFromUser(stack: string) {
 
 const alwaysActive = () => true;
 
+const tick = promisify(setImmediate);
+
+function runGarbageCollector() {
+  const isGarbageCollectorHidden = !global.gc;
+
+  // GC is usually hidden, so we have to expose it before running.
+  setFlagsFromString('--expose-gc');
+  runInNewContext('gc')();
+
+  // The GC was not initially exposed, so let's hide it again.
+  if (isGarbageCollectorHidden) {
+    setFlagsFromString('--no-expose-gc');
+  }
+}
+
 // Inspired by https://github.com/mafintosh/why-is-node-running/blob/master/index.js
 // Extracted as we want to format the result ourselves
-export default function collectHandles(): () => Array<Error> {
-  const activeHandles: Map<
+export default function collectHandles(): HandleCollectionResult {
+  const activeHandles = new Map<
     number,
     {error: Error; isActive: () => boolean}
-  > = new Map();
+  >();
   const hook = asyncHooks.createHook({
     destroy(asyncId) {
       activeHandles.delete(asyncId);
@@ -88,7 +108,14 @@ export default function collectHandles(): () => Array<Error> {
 
   hook.enable();
 
-  return (): Array<Error> => {
+  return async () => {
+    runGarbageCollector();
+
+    // wait some ticks to allow GC to run properly, see https://github.com/nodejs/node/issues/34636#issuecomment-669366235
+    for (let i = 0; i < 10; i++) {
+      await tick();
+    }
+
     hook.disable();
 
     // Get errors for every async resource still referenced at this moment
diff --git a/packages/jest-core/src/runJest.ts b/packages/jest-core/src/runJest.ts
index 008f102a4a4e..9000e6da7b5a 100644
--- a/packages/jest-core/src/runJest.ts
+++ b/packages/jest-core/src/runJest.ts
@@ -26,7 +26,7 @@ import type FailedTestsCache from './FailedTestsCache';
 import SearchSource from './SearchSource';
 import TestScheduler, {TestSchedulerContext} from './TestScheduler';
 import type TestWatcher from './TestWatcher';
-import collectNodeHandles from './collectHandles';
+import collectNodeHandles, {HandleCollectionResult} from './collectHandles';
 import getNoTestsFoundMessage from './getNoTestsFoundMessage';
 import runGlobalHook from './runGlobalHook';
 import type {Filter, TestRunData} from './types';
@@ -70,12 +70,12 @@ type ProcessResultOptions = Pick<
   Config.GlobalConfig,
   'json' | 'outputFile' | 'testResultsProcessor'
 > & {
-  collectHandles?: () => Array<Error>;
+  collectHandles?: HandleCollectionResult;
   onComplete?: (result: AggregatedResult) => void;
   outputStream: NodeJS.WriteStream;
 };
 
-const processResults = (
+const processResults = async (
   runResults: AggregatedResult,
   options: ProcessResultOptions,
 ) => {
@@ -89,7 +89,7 @@ const processResults = (
   } = options;
 
   if (collectHandles) {
-    runResults.openHandles = collectHandles();
+    runResults.openHandles = await collectHandles();
   } else {
     runResults.openHandles = [];
   }
@@ -111,7 +111,7 @@ const processResults = (
     }
   }
 
-  return onComplete && onComplete(runResults);
+  onComplete?.(runResults);
 };
 
 const testSchedulerContext: TestSchedulerContext = {