diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6c74a6b548c5..0017592475c4 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,7 @@
 - `[jest-resolve-dependencies]` Resolve mocks as dependencies ([#10713](https://github.com/facebook/jest/pull/10713))
 - `[jest-runtime]` Handle file URLs in dynamic imports ([#10744](https://github.com/facebook/jest/pull/10744))
 - `[jest-runtime, babel-jest]` Pass more ESM options to `@jest/transform` ([#10752](https://github.com/facebook/jest/pull/10752))
+- `[jest-runtime]` Properly inject `extraGlobals` into the runtime ([#10758](https://github.com/facebook/jest/pull/10758))
 - `[jest-transform]` Link to ESM docs on syntax errors ([#10748](https://github.com/facebook/jest/pull/10748))
 
 ### Chore & Maintenance
diff --git a/e2e/__tests__/extraGlobals.test.ts b/e2e/__tests__/extraGlobals.test.ts
new file mode 100644
index 000000000000..62d063f66895
--- /dev/null
+++ b/e2e/__tests__/extraGlobals.test.ts
@@ -0,0 +1,34 @@
+/**
+ * Copyright (c) Facebook, Inc. and its affiliates. All Rights Reserved.
+ *
+ * This source code is licensed under the MIT license found in the
+ * LICENSE file in the root directory of this source tree.
+ */
+
+import {tmpdir} from 'os';
+import * as path from 'path';
+import {cleanup, createEmptyPackage, writeFiles} from '../Utils';
+import {json as runJest} from '../runJest';
+
+const DIR = path.resolve(tmpdir(), 'extra-globals');
+
+beforeEach(() => {
+  cleanup(DIR);
+  createEmptyPackage(DIR, {jest: {extraGlobals: ['Math']}});
+});
+
+afterAll(() => cleanup(DIR));
+
+test('works with injected globals', () => {
+  writeFiles(DIR, {
+    'test.js': `
+       test('Math works when injected', () => {
+         expect(Math.floor(1.5)).toBe(1);
+       });
+  `,
+  });
+
+  const {exitCode} = runJest(DIR);
+
+  expect(exitCode).toBe(0);
+});
diff --git a/packages/jest-runtime/src/index.ts b/packages/jest-runtime/src/index.ts
index 1f8f8f7ef6a7..8a443a8eef9e 100644
--- a/packages/jest-runtime/src/index.ts
+++ b/packages/jest-runtime/src/index.ts
@@ -1095,9 +1095,9 @@ class Runtime {
 
     this.jestObjectCaches.set(filename, jestObject);
 
-    const lastArgs: [Jest | undefined, ...Array<any>] = [
+    const lastArgs: [Jest | undefined, ...Array<Global.Global>] = [
       this._config.injectGlobals ? jestObject : undefined, // jest object
-      this._config.extraGlobals.map<unknown>(globalVariable => {
+      ...this._config.extraGlobals.map<Global.Global>(globalVariable => {
         if (this._environment.global[globalVariable]) {
           return this._environment.global[globalVariable];
         }
@@ -1126,6 +1126,7 @@ class Runtime {
         module.path, // __dirname
         module.filename, // __filename
         this._environment.global, // global object
+        // @ts-expect-error
         ...lastArgs.filter(notEmpty),
       );
     } catch (error) {