diff --git a/src/Mutator/Extensions/BCMath.php b/src/Mutator/Extensions/BCMath.php
index d734724019..921d32f4bf 100644
--- a/src/Mutator/Extensions/BCMath.php
+++ b/src/Mutator/Extensions/BCMath.php
@@ -217,6 +217,10 @@ private static function makeCastToStringMapper(Closure $converter): Closure
     private static function makeBinaryOperatorMapper(string $operator): Closure
     {
         return static function (Node\Expr\FuncCall $node) use ($operator): iterable {
+            if ($node->args[0] instanceof Node\VariadicPlaceholder || $node->args[1] instanceof Node\VariadicPlaceholder) {
+                return [];
+            }
+
             yield new $operator($node->args[0]->value, $node->args[1]->value);
         };
     }
@@ -237,6 +241,10 @@ private static function makeSquareRootsMapper(): Closure
     private static function makePowerModuloMapper(): Closure
     {
         return static function (Node\Expr\FuncCall $node): iterable {
+            if ($node->args[2] instanceof Node\VariadicPlaceholder) {
+                return [];
+            }
+
             yield new Node\Expr\BinaryOp\Mod(
                 new Node\Expr\FuncCall(
                     new Node\Name('\pow'),
diff --git a/src/Mutator/Extensions/MBString.php b/src/Mutator/Extensions/MBString.php
index 7bf1199817..10742cac30 100644
--- a/src/Mutator/Extensions/MBString.php
+++ b/src/Mutator/Extensions/MBString.php
@@ -202,6 +202,10 @@ private static function getConvertCaseModeValue(Node\Expr\FuncCall $node): ?int
             return null;
         }
 
+        if ($node->args[1] instanceof Node\VariadicPlaceholder) {
+            return null;
+        }
+
         $mode = $node->args[1]->value;
 
         if ($mode instanceof Node\Scalar\LNumber) {
@@ -244,7 +248,7 @@ private static function isInMbCaseMode(int $mode, string ...$cases): bool
     }
 
     /**
-     * @param Node\Arg[] $args
+     * @param array<Node\Arg|Node\VariadicPlaceholder> $args
      */
     private static function mapFunctionCall(Node\Expr\FuncCall $node, string $newFuncName, array $args): Node\Expr\FuncCall
     {
diff --git a/src/Mutator/Regex/AbstractPregMatch.php b/src/Mutator/Regex/AbstractPregMatch.php
index 0d46860f93..cf5824386d 100644
--- a/src/Mutator/Regex/AbstractPregMatch.php
+++ b/src/Mutator/Regex/AbstractPregMatch.php
@@ -60,14 +60,16 @@ abstract class AbstractPregMatch implements Mutator
      */
     public function mutate(Node $node): iterable
     {
-        $arguments = $node->args;
-        $firstArgument = $arguments[0];
-        $originalRegex = $this->pullOutRegex($firstArgument);
+        if ($node->args[0] instanceof Node\VariadicPlaceholder) {
+            return [];
+        }
+
+        $originalRegex = $this->pullOutRegex($node->args[0]);
 
         foreach ($this->mutateRegex($originalRegex) as $mutatedRegex) {
-            $newArgument = $this->getNewRegexArgument($mutatedRegex, $firstArgument);
+            $newArgument = $this->getNewRegexArgument($mutatedRegex, $node->args[0]);
 
-            yield new FuncCall($node->name, [$newArgument] + $arguments, $node->getAttributes());
+            yield new FuncCall($node->name, [$newArgument] + $node->args, $node->getAttributes());
         }
     }
 
@@ -76,6 +78,7 @@ public function canMutate(Node $node): bool
         return $node instanceof FuncCall
             && $node->name instanceof Node\Name
             && strtolower((string) $node->name) === 'preg_match'
+            && $node->args[0] instanceof Node\Arg
             && $node->args[0]->value instanceof Node\Scalar\String_
             && $this->isProperRegexToMutate($this->pullOutRegex($node->args[0]));
     }
diff --git a/src/Mutator/Regex/PregMatchMatches.php b/src/Mutator/Regex/PregMatchMatches.php
index a7b328dcad..310af0e3b6 100644
--- a/src/Mutator/Regex/PregMatchMatches.php
+++ b/src/Mutator/Regex/PregMatchMatches.php
@@ -89,6 +89,10 @@ public static function getDefinition(): ?Definition
      */
     public function mutate(Node $node): iterable
     {
+        if ($node->args[2] instanceof Node\VariadicPlaceholder) {
+            return [];
+        }
+
         yield new Node\Expr\Cast\Int_(new Node\Expr\Assign($node->args[2]->value, new Node\Expr\Array_()));
     }
 
diff --git a/src/Mutator/Regex/PregQuote.php b/src/Mutator/Regex/PregQuote.php
index f6dbb3db28..072cf1d8d8 100644
--- a/src/Mutator/Regex/PregQuote.php
+++ b/src/Mutator/Regex/PregQuote.php
@@ -84,6 +84,10 @@ public static function getDefinition(): ?Definition
      */
     public function mutate(Node $node): iterable
     {
+        if ($node->args[0] instanceof Node\VariadicPlaceholder) {
+            return [];
+        }
+
         yield $node->args[0];
     }
 
diff --git a/src/Mutator/Unwrap/AbstractUnwrapMutator.php b/src/Mutator/Unwrap/AbstractUnwrapMutator.php
index 6fb42c6834..f9c48ae314 100644
--- a/src/Mutator/Unwrap/AbstractUnwrapMutator.php
+++ b/src/Mutator/Unwrap/AbstractUnwrapMutator.php
@@ -58,6 +58,10 @@ abstract class AbstractUnwrapMutator implements Mutator
     final public function mutate(Node $node): iterable
     {
         foreach ($this->getParameterIndexes($node) as $index) {
+            if ($node->args[$index] instanceof Node\VariadicPlaceholder) {
+                continue;
+            }
+
             if ($node->args[$index]->unpack) {
                 continue;
             }