diff --git a/infection.json.dist b/infection.json.dist
index 7827eb88b..e6852ad96 100644
--- a/infection.json.dist
+++ b/infection.json.dist
@@ -10,5 +10,12 @@
         "badge": {
             "branch": "master"
         }
+    },
+    "mutators": {
+        "MethodCallRemoval": {
+            "ignore": [
+                "Infection\\Finder\\SourceFilesFinder::__construct::63"
+            ]
+        }
     }
 }
diff --git a/src/Mutator/Util/Mutator.php b/src/Mutator/Util/Mutator.php
index 019a2e08b..551f0943d 100644
--- a/src/Mutator/Util/Mutator.php
+++ b/src/Mutator/Util/Mutator.php
@@ -67,7 +67,11 @@ final public function shouldMutate(Node $node): bool
             return true;
         }
 
-        return !$this->config->isIgnored($reflectionClass->getName(), $node->getAttribute(ReflectionVisitor::FUNCTION_NAME, ''));
+        return !$this->config->isIgnored(
+            $reflectionClass->getName(),
+            $node->getAttribute(ReflectionVisitor::FUNCTION_NAME, ''),
+            $node->getLine()
+        );
     }
 
     final public static function getName(): string
diff --git a/src/Mutator/Util/MutatorConfig.php b/src/Mutator/Util/MutatorConfig.php
index d7e1c0618..6eb89339e 100644
--- a/src/Mutator/Util/MutatorConfig.php
+++ b/src/Mutator/Util/MutatorConfig.php
@@ -56,7 +56,7 @@ public function __construct(array $config)
         $this->mutatorSettings = $config['settings'] ?? [];
     }
 
-    public function isIgnored(string $class, string $method): bool
+    public function isIgnored(string $class, string $method, int $lineNumber = null): bool
     {
         if (\in_array($class, $this->ignoreConfig)) {
             return true;
@@ -67,7 +67,10 @@ public function isIgnored(string $class, string $method): bool
         }
 
         foreach ($this->ignoreConfig as $ignorePattern) {
-            if (fnmatch($ignorePattern, $class, FNM_NOESCAPE) || fnmatch($ignorePattern, $class . '::' . $method, FNM_NOESCAPE)) {
+            if (fnmatch($ignorePattern, $class, FNM_NOESCAPE)
+                || fnmatch($ignorePattern, $class . '::' . $method, FNM_NOESCAPE)
+                || ($lineNumber !== null && fnmatch($ignorePattern, $class . '::' . $method . '::' . $lineNumber, FNM_NOESCAPE))
+            ) {
                 return true;
             }
         }
diff --git a/tests/Mutator/Util/MutatorConfigTest.php b/tests/Mutator/Util/MutatorConfigTest.php
index e766b6a7d..617d57848 100644
--- a/tests/Mutator/Util/MutatorConfigTest.php
+++ b/tests/Mutator/Util/MutatorConfigTest.php
@@ -46,11 +46,11 @@ final class MutatorConfigTest extends TestCase
     /**
      * @dataProvider providesIgnoredValues
      */
-    public function test_is_ignored_returns_true_if_there_is_a_match(array $ignored, string $class, string $method): void
+    public function test_is_ignored_returns_true_if_there_is_a_match(array $ignored, string $class, string $method, int $lineNumber = null): void
     {
         $config = new MutatorConfig(['ignore' => $ignored]);
 
-        $this->assertTrue($config->isIgnored($class, $method));
+        $this->assertTrue($config->isIgnored($class, $method, $lineNumber));
     }
 
     public function providesIgnoredValues(): \Generator
@@ -90,6 +90,13 @@ public function providesIgnoredValues(): \Generator
             'Foo\Bar\Test',
             'method',
         ];
+
+        yield 'It ignores a specific line number' => [
+            ['Foo\Bar\Test::method::63'],
+            'Foo\Bar\Test',
+            'method',
+            63,
+        ];
     }
 
     /**