diff --git a/Cargo.toml b/Cargo.toml
index bd30db578b..4a31e9b814 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -30,7 +30,7 @@ gif = { version = "0.10.0", optional = true }
 jpeg = { package = "jpeg-decoder", version = "0.1.17", default-features = false, optional = true }
 png = { version = "0.16.0", optional = true }
 scoped_threadpool = { version = "0.1", optional = true }
-tiff = { version = "0.4.0", optional = true }
+tiff = { version = "0.5.0", optional = true }
 
 [dev-dependencies]
 crc32fast = "1.2.0"
diff --git a/Cargo.toml.public-private-dependencies b/Cargo.toml.public-private-dependencies
index 281b0281ef..6f8ce64e3b 100644
--- a/Cargo.toml.public-private-dependencies
+++ b/Cargo.toml.public-private-dependencies
@@ -34,7 +34,7 @@ gif = { version = "0.10.0", optional = true }
 jpeg = { package = "jpeg-decoder", version = "0.1.17", default-features = false, optional = true }
 png = { version = "0.16.0", optional = true }
 scoped_threadpool = { version = "0.1", optional = true }
-tiff = { version = "0.4.0", optional = true }
+tiff = { version = "0.5.0", optional = true }
 
 [dev-dependencies]
 crc32fast = "1.2.0"
diff --git a/src/tiff.rs b/src/tiff.rs
index 91425babf3..1a28211c9a 100644
--- a/src/tiff.rs
+++ b/src/tiff.rs
@@ -13,15 +13,13 @@ use std::io::{self, Cursor, Read, Write, Seek};
 use std::marker::PhantomData;
 use std::mem;
 
-use byteorder::{NativeEndian, ByteOrder};
-
 use crate::color::{ColorType, ExtendedColorType};
 use crate::error::{
     DecodingError, EncodingError, ImageError, ImageResult, LimitError, LimitErrorKind,
     ParameterError, ParameterErrorKind, UnsupportedError, UnsupportedErrorKind,
 };
 use crate::image::{ImageDecoder, ImageEncoder, ImageFormat};
-use crate::utils::vec_u16_into_u8;
+use crate::utils;
 
 /// Decoder for TIFF images.
 pub struct TiffDecoder<R>
@@ -78,7 +76,7 @@ impl ImageError {
     fn from_tiff_decode(err: tiff::TiffError) -> ImageError {
         match err {
             tiff::TiffError::IoError(err) => ImageError::IoError(err),
-            err @ tiff::TiffError::FormatError(_) => {
+            err @ tiff::TiffError::FormatError(_) | err @ tiff::TiffError::IntSizeError => {
                 ImageError::Decoding(DecodingError::new(ImageFormat::Tiff.into(), err))
             }
             tiff::TiffError::UnsupportedError(desc) => {
@@ -96,7 +94,7 @@ impl ImageError {
     fn from_tiff_encode(err: tiff::TiffError) -> ImageError {
         match err {
             tiff::TiffError::IoError(err) => ImageError::IoError(err),
-            err @ tiff::TiffError::FormatError(_) => {
+            err @ tiff::TiffError::FormatError(_) | err @ tiff::TiffError::IntSizeError => {
                 ImageError::Encoding(EncodingError::new(ImageFormat::Tiff.into(), err))
             }
             tiff::TiffError::UnsupportedError(desc) => {
@@ -146,7 +144,9 @@ impl<'a, R: 'a + Read + Seek> ImageDecoder<'a> for TiffDecoder<R> {
             .map_err(ImageError::from_tiff_decode)?
         {
             tiff::decoder::DecodingResult::U8(v) => v,
-            tiff::decoder::DecodingResult::U16(v) => vec_u16_into_u8(v),
+            tiff::decoder::DecodingResult::U16(v) => utils::vec_u16_into_u8(v),
+            tiff::decoder::DecodingResult::U32(v) => utils::vec_u32_into_u8(v),
+            tiff::decoder::DecodingResult::U64(v) => utils::vec_u64_into_u8(v),
         };
 
         Ok(TiffReader(Cursor::new(buf), PhantomData))
@@ -163,7 +163,13 @@ impl<'a, R: 'a + Read + Seek> ImageDecoder<'a> for TiffDecoder<R> {
                 buf.copy_from_slice(&v);
             }
             tiff::decoder::DecodingResult::U16(v) => {
-                NativeEndian::write_u16_into(&v, buf);
+                buf.copy_from_slice(bytemuck::cast_slice(&v));
+            }
+            tiff::decoder::DecodingResult::U32(v) => {
+                buf.copy_from_slice(bytemuck::cast_slice(&v));
+            }
+            tiff::decoder::DecodingResult::U64(v) => {
+                buf.copy_from_slice(bytemuck::cast_slice(&v));
             }
         }
         Ok(())
diff --git a/src/utils/mod.rs b/src/utils/mod.rs
index 4b4fda670b..561115da35 100644
--- a/src/utils/mod.rs
+++ b/src/utils/mod.rs
@@ -1,8 +1,6 @@
 //!  Utilities
 
-use byteorder::{NativeEndian, ByteOrder};
 use num_iter::range_step;
-use std::mem;
 use std::iter::repeat;
 
 #[inline(always)]
@@ -69,15 +67,30 @@ pub(crate) fn expand_bits(bit_depth: u8, row_size: u32, buf: &[u8]) -> Vec<u8> {
 // When no image formats that use it are enabled
 pub(crate) fn vec_u16_into_u8(vec: Vec<u16>) -> Vec<u8> {
     // Do this way until we find a way to not alloc/dealloc but get llvm to realloc instead.
-    vec_u16_copy_u8(&vec)
+    vec_copy_to_u8(&vec)
 }
 
 #[allow(dead_code)]
 // When no image formats that use it are enabled
-pub(crate) fn vec_u16_copy_u8(vec: &[u16]) -> Vec<u8> {
-    let mut new = vec![0; vec.len() * mem::size_of::<u16>()];
-    NativeEndian::write_u16_into(&vec[..], &mut new[..]);
-    new
+pub(crate) fn vec_u32_into_u8(vec: Vec<u32>) -> Vec<u8> {
+    // Do this way until we find a way to not alloc/dealloc but get llvm to realloc instead.
+    vec_copy_to_u8(&vec)
+}
+
+#[allow(dead_code)]
+// When no image formats that use it are enabled
+pub(crate) fn vec_u64_into_u8(vec: Vec<u64>) -> Vec<u8> {
+    // Do this way until we find a way to not alloc/dealloc but get llvm to realloc instead.
+    vec_copy_to_u8(&vec)
+}
+
+#[allow(dead_code)]
+// When no image formats that use it are enabled
+pub(crate) fn vec_copy_to_u8<T>(vec: &[T]) -> Vec<u8>
+where
+    T: bytemuck::Pod,
+{
+    bytemuck::cast_slice(vec).to_owned()
 }