diff --git a/setup.py b/setup.py
index b966d7a7..23131ef3 100644
--- a/setup.py
+++ b/setup.py
@@ -37,8 +37,8 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-cloud-core >= 1.4.0, <3.0.0dev",
-    "proto-plus >= 1.15.0, <2.0.0dev",
-    "protobuf >= 3.19.0, <4.0.0dev",
+    "proto-plus >= 1.22.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <5.0.0dev",
 ]
 extras = {"libcst": "libcst >= 0.2.5"}
 
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index b6789fb7..e3a84dcc 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -7,6 +7,6 @@
 # Then this file should have foo==1.14.0
 google-api-core==1.31.5
 google-cloud-core==1.4.0
-proto-plus==1.15.0
+proto-plus==1.22.0
 libcst==0.2.5
 protobuf==3.19.0