diff --git a/.github/workflows/python-deps.yml b/.github/workflows/python-deps.yml
index 3c616cf675..28efa81053 100644
--- a/.github/workflows/python-deps.yml
+++ b/.github/workflows/python-deps.yml
@@ -18,6 +18,11 @@ jobs:
           os: [ubuntu-latest, macos-latest]
           python_deps_type: [pipenv, poetry, requirements, setup_py]
           python_version: [2, 3]
+          exclude:
+            # Python2 and poetry are not supported. See https://github.com/actions/setup-python/issues/374
+            - python_version: 2
+              python_deps_type: poetry
+
 
     env:
       PYTHON_DEPS_TYPE: ${{ matrix.python_deps_type }}
@@ -115,6 +120,10 @@ jobs:
         matrix:
           python_deps_type: [pipenv, poetry, requirements, setup_py]
           python_version: [2, 3]
+          exclude:
+            # Python2 and poetry are not supported. See https://github.com/actions/setup-python/issues/374
+            - python_version: 2
+              python_deps_type: poetry
 
     env:
       PYTHON_DEPS_TYPE: ${{ matrix.python_deps_type }}
diff --git a/CHANGELOG.md b/CHANGELOG.md
index b6c93d3baf..4af60e5709 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -3,6 +3,7 @@
 ## [UNRELEASED]
 
 - CodeQL query packs listed in the `packs` configuration field will be skipped if their target language is not being analyzed in the current Actions job. Previously, this would throw an error. [#1116](https://github.com/github/codeql-action/pull/1116)
+- The combination of python2 and poetry is no longer supported. See https://github.com/actions/setup-python/issues/374 for more details. [#1124](https://github.com/github/codeql-action/pull/1124)
 
 ## 2.1.14 - 22 Jun 2022