diff --git a/packages/react-dom/src/client/ReactInputSelection.js b/packages/react-dom/src/client/ReactInputSelection.js
index 54ad4a937f33..f2d0987608b3 100644
--- a/packages/react-dom/src/client/ReactInputSelection.js
+++ b/packages/react-dom/src/client/ReactInputSelection.js
@@ -40,15 +40,29 @@ function isInDocument(node) {
   );
 }
 
+function isSameOriginFrame(iframe) {
+  try {
+    // Accessing the contentDocument of a HTMLIframeElement can cause the browser
+    // to throw, e.g. if it has a cross-origin src attribute.
+    // Safari will show an error in the console when the access results in "Blocked a frame with origin". e.g:
+    // iframe.contentDocument.defaultView;
+    // A safety way is to access one of the cross origin properties: Window or Location
+    // Which might result in "SecurityError" DOM Exception and it is compatible to Safari.
+    // https://html.spec.whatwg.org/multipage/browsers.html#integration-with-idl
+
+    return typeof iframe.contentWindow.location.href === 'string';
+  } catch (err) {
+    return false;
+  }
+}
+
 function getActiveElementDeep() {
   let win = window;
   let element = getActiveElement();
   while (element instanceof win.HTMLIFrameElement) {
-    // Accessing the contentDocument of a HTMLIframeElement can cause the browser
-    // to throw, e.g. if it has a cross-origin src attribute
-    try {
-      win = element.contentDocument.defaultView;
-    } catch (e) {
+    if (isSameOriginFrame(element)) {
+      win = element.contentWindow;
+    } else {
       return element;
     }
     element = getActiveElement(win.document);