diff --git a/conan/tools/cmake/toolchain.py b/conan/tools/cmake/toolchain.py
index b1168ebc354..631cbbc3620 100644
--- a/conan/tools/cmake/toolchain.py
+++ b/conan/tools/cmake/toolchain.py
@@ -319,7 +319,8 @@ class AppleSystemBlock(Block):
         # but full path is necessary for others
         set(CMAKE_OSX_SYSROOT {{ CMAKE_OSX_SYSROOT }} CACHE STRING "" FORCE)
         {% if CMAKE_OSX_DEPLOYMENT_TARGET is defined %}
-        set(CMAKE_OSX_DEPLOYMENT_TARGET {{ CMAKE_OSX_DEPLOYMENT_TARGET }})
+        # Setting CMAKE_OSX_DEPLOYMENT_TARGET if "os.version" is defined by the used conan profile
+        set(CMAKE_OSX_DEPLOYMENT_TARGET "{{ CMAKE_OSX_DEPLOYMENT_TARGET }}" CACHE STRING "")
         {% endif %}
         """)
 
diff --git a/conans/test/unittests/tools/cmake/test_cmaketoolchain.py b/conans/test/unittests/tools/cmake/test_cmaketoolchain.py
index 081d518c686..d9a285e2e30 100644
--- a/conans/test/unittests/tools/cmake/test_cmaketoolchain.py
+++ b/conans/test/unittests/tools/cmake/test_cmaketoolchain.py
@@ -164,4 +164,4 @@ def conanfile_apple():
 def test_osx_deployment_target(conanfile_apple):
     toolchain = CMakeToolchain(conanfile_apple)
     content = toolchain.content
-    assert 'set(CMAKE_OSX_DEPLOYMENT_TARGET 10.15)' in content
+    assert 'set(CMAKE_OSX_DEPLOYMENT_TARGET "10.15" CACHE STRING "")' in content