diff --git a/conans/client/conan_api.py b/conans/client/conan_api.py
index 6ffa2190141..53e04dfe2a5 100644
--- a/conans/client/conan_api.py
+++ b/conans/client/conan_api.py
@@ -1437,6 +1437,7 @@ def lock_create(self, path, lockfile_out,
                     base=None, lockfile=None):
         # profile_host is mandatory
         profile_host = profile_host or ProfileData(None, None, None, None, None)
+        profile_build = profile_build or ProfileData(None, None, None, None, None)
         cwd = os.getcwd()
 
         if path and reference:
@@ -1467,11 +1468,11 @@ def lock_create(self, path, lockfile_out,
                                       profile_host.options, profile_host.env, profile_host.conf,
                                       cwd, self.app.cache)
 
-        if profile_build and not pbuild:
+        if not pbuild:
             # Only work on the profile_build if something is provided
             pbuild = profile_from_args(profile_build.profiles, profile_build.settings,
                                        profile_build.options, profile_build.env, profile_build.conf,
-                                       cwd, self.app.cache)
+                                       cwd, self.app.cache, build_profile=True)
 
         root_ref = ConanFileReference(name, version, user, channel, validate=False)
         phost.process_settings(self.app.cache)
@@ -1557,14 +1558,14 @@ def get_graph_info(profile_host, profile_build, cwd, install_folder, cache, outp
         phost = profile_from_args(profile_host.profiles, profile_host.settings, profile_host.options,
                                   profile_host.env, profile_host.conf, cwd, cache)
         phost.process_settings(cache)
-        if profile_build:
-            # Only work on the profile_build if something is provided
-            pbuild = profile_from_args(profile_build.profiles, profile_build.settings,
-                                       profile_build.options, profile_build.env, profile_build.conf,
-                                       cwd, cache)
+
+        profile_build = profile_build or ProfileData(None, None, None, None, None)
+        # Only work on the profile_build if something is provided
+        pbuild = profile_from_args(profile_build.profiles, profile_build.settings,
+                                   profile_build.options, profile_build.env, profile_build.conf,
+                                   cwd, cache, build_profile=True)
+        if pbuild is not None:
             pbuild.process_settings(cache)
-        else:
-            pbuild = None
 
         root_ref = ConanFileReference(name, version, user, channel, validate=False)
         graph_info = GraphInfo(profile_host=phost, profile_build=pbuild, root_ref=root_ref)
diff --git a/conans/client/profile_loader.py b/conans/client/profile_loader.py
index 5683766361b..1ff366141d8 100644
--- a/conans/client/profile_loader.py
+++ b/conans/client/profile_loader.py
@@ -242,13 +242,25 @@ def get_package_name_value(item):
         base_profile.buildenv.update_profile_env(buildenv)
 
 
-def profile_from_args(profiles, settings, options, env, conf, cwd, cache):
+def profile_from_args(profiles, settings, options, env, conf, cwd, cache, build_profile=False):
     """ Return a Profile object, as the result of merging a potentially existing Profile
     file and the args command-line arguments
     """
-    default_profile = cache.default_profile  # Ensures a default profile creating
+    # Ensures a default profile creating
+    default_profile = cache.default_profile
+    create_profile = profiles or settings or options or env or conf or not build_profile
+
     if profiles is None:
-        result = default_profile
+        default_name = "core:default_build_profile" if build_profile else "core:default_profile"
+        default_conf = cache.new_config[default_name]
+        if default_conf is not None:
+            default_profile_path = default_conf if os.path.isabs(default_conf) \
+                else os.path.join(cache.profiles_path, default_conf)
+            result, _ = read_profile(default_profile_path, os.getcwd(), cache.profiles_path)
+        elif create_profile:
+            result = default_profile
+        else:
+            result = None
     else:
         result = Profile()
         for p in profiles:
@@ -260,7 +272,8 @@ def profile_from_args(profiles, settings, options, env, conf, cwd, cache):
     if result:
         result.compose_profile(args_profile)
     else:
-        result = args_profile
+        if create_profile:
+            result = args_profile
     return result
 
 
diff --git a/conans/test/integration/configuration/default_profile_test.py b/conans/test/integration/configuration/default_profile_test.py
index 9809ffbf60a..ae575e9fdda 100644
--- a/conans/test/integration/configuration/default_profile_test.py
+++ b/conans/test/integration/configuration/default_profile_test.py
@@ -1,4 +1,5 @@
 import os
+import textwrap
 import unittest
 
 from conans.client import tools
@@ -180,3 +181,19 @@ def build(self):
                           "an existing profile file.", client.out)
 
 
+def test_conf_default_two_profiles():
+    client = TestClient()
+    save(os.path.join(client.cache.profiles_path, "mydefault"), "[settings]\nos=FreeBSD")
+    save(os.path.join(client.cache.profiles_path, "mydefault_build"), "[settings]\nos=Android")
+    global_conf = textwrap.dedent("""
+        core:default_profile=mydefault
+        core:default_build_profile=mydefault_build
+        """)
+    save(client.cache.new_config_path, global_conf)
+    client.save({"conanfile.txt": ""})
+    client.run("install .")
+    assert "Configuration (profile_host):" in client.out
+    assert "os=FreeBSD" in client.out
+    assert "Configuration (profile_build):" in client.out
+    assert "os=Android" in client.out
+