diff --git a/conan/tools/cmake/toolchain/blocks.py b/conan/tools/cmake/toolchain/blocks.py
index fca65c2fc85..26576cd260b 100644
--- a/conan/tools/cmake/toolchain/blocks.py
+++ b/conan/tools/cmake/toolchain/blocks.py
@@ -852,13 +852,21 @@ def template(self):
 
         return textwrap.dedent("""
            set(CMAKE_INSTALL_PREFIX "{{package_folder}}")
+           {% if default_bin %}
            set(CMAKE_INSTALL_BINDIR "{{default_bin}}")
            set(CMAKE_INSTALL_SBINDIR "{{default_bin}}")
            set(CMAKE_INSTALL_LIBEXECDIR "{{default_bin}}")
+           {% endif %}
+           {% if default_lib %}
            set(CMAKE_INSTALL_LIBDIR "{{default_lib}}")
+           {% endif %}
+           {% if default_include %}
            set(CMAKE_INSTALL_INCLUDEDIR "{{default_include}}")
            set(CMAKE_INSTALL_OLDINCLUDEDIR "{{default_include}}")
+           {% endif %}
+           {% if default_res %}
            set(CMAKE_INSTALL_DATAROOTDIR "{{default_res}}")
+           {% endif %}
         """)
 
     def _get_cpp_info_value(self, name):
diff --git a/conans/__init__.py b/conans/__init__.py
index 1ff11cb03de..cc354d76021 100644
--- a/conans/__init__.py
+++ b/conans/__init__.py
@@ -20,4 +20,4 @@
 SERVER_CAPABILITIES = [COMPLEX_SEARCH_CAPABILITY, REVISIONS]  # Server is always with revisions
 DEFAULT_REVISION_V1 = "0"
 
-__version__ = '1.50.0'
+__version__ = '1.50.1'
diff --git a/conans/client/migrations_settings.py b/conans/client/migrations_settings.py
index 25b2bd1bf09..b66cb0cdc72 100644
--- a/conans/client/migrations_settings.py
+++ b/conans/client/migrations_settings.py
@@ -3713,3 +3713,4 @@
 """
 
 settings_1_50_0 = settings_1_49_0
+settings_1_50_1 = settings_1_50_0
diff --git a/conans/test/functional/toolchains/cmake/test_cmake_toolchain.py b/conans/test/functional/toolchains/cmake/test_cmake_toolchain.py
index c7101504c78..095ae5c61aa 100644
--- a/conans/test/functional/toolchains/cmake/test_cmake_toolchain.py
+++ b/conans/test/functional/toolchains/cmake/test_cmake_toolchain.py
@@ -918,3 +918,94 @@ def test_cmake_presets_forbidden_build_type():
     client.run("install . {}".format(settings_layout), assert_error=True)
     assert "Error, don't include 'settings.build_type' in the " \
            "'tools.cmake.cmake_layout:build_folder_vars' conf" in client.out
+
+
+def test_resdirs_cmake_install():
+    """If resdirs is declared, the CMAKE_INSTALL_DATAROOTDIR folder is set"""
+
+    client = TestClient(path_with_spaces=False)
+
+    conanfile = textwrap.dedent("""
+            from conan import ConanFile
+            from conan.tools.cmake import CMakeToolchain, CMake, cmake_layout
+
+            class AppConan(ConanFile):
+                settings = "os", "compiler", "build_type", "arch"
+                exports_sources = "CMakeLists.txt", "my_license"
+                name = "foo"
+                version = "1.0"
+
+                def generate(self):
+                    tc = CMakeToolchain(self)
+                    tc.generate()
+
+                def layout(self):
+                    self.cpp.package.resdirs = ["res"]
+
+                def build(self):
+                    cmake = CMake(self)
+                    cmake.configure()
+                    cmake.build()
+
+                def package(self):
+                    cmake = CMake(self)
+                    cmake.install()
+            """)
+
+    cmake = """
+    cmake_minimum_required(VERSION 3.15)
+    set(CMAKE_CXX_COMPILER_WORKS 1)
+    project(foo)
+    if(NOT CMAKE_INSTALL_DATAROOTDIR)
+        message(FATAL_ERROR "Cannot install stuff")
+    endif()
+    install(FILES my_license DESTINATION ${CMAKE_INSTALL_DATAROOTDIR}/licenses)
+    """
+
+    client.save({"conanfile.py": conanfile, "CMakeLists.txt": cmake, "my_license": "MIT"})
+    client.run("create .")
+    assert "/res/licenses/my_license" in client.out
+    assert "Packaged 1 file: my_license" in client.out
+
+
+def test_resdirs_none_cmake_install():
+    """If no resdirs are declared, the CMAKE_INSTALL_DATAROOTDIR folder is not set"""
+
+    client = TestClient(path_with_spaces=False)
+
+    conanfile = textwrap.dedent("""
+            from conan import ConanFile
+            from conan.tools.cmake import CMakeToolchain, CMake, cmake_layout
+
+            class AppConan(ConanFile):
+                settings = "os", "compiler", "build_type", "arch"
+                exports_sources = "CMakeLists.txt", "my_license"
+                name = "foo"
+                version = "1.0"
+
+                def generate(self):
+                    tc = CMakeToolchain(self)
+                    tc.generate()
+
+                def build(self):
+                    cmake = CMake(self)
+                    cmake.configure()
+                    cmake.build()
+
+                def package(self):
+                    cmake = CMake(self)
+                    cmake.install()
+            """)
+
+    cmake = """
+    cmake_minimum_required(VERSION 3.15)
+    set(CMAKE_CXX_COMPILER_WORKS 1)
+    project(foo)
+    if(NOT CMAKE_INSTALL_DATAROOTDIR)
+        message(FATAL_ERROR "Cannot install stuff")
+    endif()
+    """
+
+    client.save({"conanfile.py": conanfile, "CMakeLists.txt": cmake, "my_license": "MIT"})
+    client.run("create .", assert_error=True)
+    assert "Cannot install stuff" in client.out