diff --git a/.github/workflows/testing.yml b/.github/workflows/testing.yml
index be034ae9..6566800e 100644
--- a/.github/workflows/testing.yml
+++ b/.github/workflows/testing.yml
@@ -29,7 +29,7 @@ jobs:
     strategy:
       matrix:
         os: [ubuntu-latest, windows-latest, macos-latest]
-        python_version: [3.5, 3.6, 3.7, 3.8, 3.9, "3.10-dev", "pypy3"]
+        python_version: [3.6, 3.7, 3.8, 3.9, "3.10-dev", "pypy3"]
         exclude:
           # Do not test all minor versions on all platforms, especially if they
           # are not the oldest/newest supported versions
diff --git a/CHANGES.md b/CHANGES.md
index 211fdc87..2e1b6f00 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -4,6 +4,8 @@
 dev
 ===
 
+- Python 3.5 is no longer supported.
+
 - Fix a side effect altering dynamic modules at pickling time.
   ([PR #426](https://github.com/cloudpipe/cloudpickle/pull/426))
 
diff --git a/setup.py b/setup.py
index c429a014..c0ed734f 100644
--- a/setup.py
+++ b/setup.py
@@ -39,7 +39,6 @@ def find_version():
         'Operating System :: POSIX',
         'Operating System :: Microsoft :: Windows',
         'Operating System :: MacOS :: MacOS X',
-        'Programming Language :: Python :: 3.5',
         'Programming Language :: Python :: 3.6',
         'Programming Language :: Python :: 3.7',
         'Programming Language :: Python :: 3.8',
@@ -51,5 +50,5 @@ def find_version():
         'Topic :: System :: Distributed Computing',
     ],
     test_suite='tests',
-    python_requires='>=3.5',
+    python_requires='>=3.6',
 )