diff --git a/cloudpickle/cloudpickle.py b/cloudpickle/cloudpickle.py
index 8e683e7a6..6043fd8ab 100644
--- a/cloudpickle/cloudpickle.py
+++ b/cloudpickle/cloudpickle.py
@@ -44,6 +44,7 @@
 
 import builtins
 import dis
+import inspect
 import opcode
 import platform
 import sys
@@ -87,6 +88,9 @@ def g():
 # communication speed over compatibility:
 DEFAULT_PROTOCOL = pickle.HIGHEST_PROTOCOL
 
+# Names of modules whose resources should be treated as dynamic.
+_CUSTOM_DYNAMIC_MODULES_BY_NAME = set()
+
 # Track the provenance of reconstructed dynamic classes to make it possible to
 # recontruct instances from the matching singleton class definition when
 # appropriate and preserve the usual "isinstance" semantics of Python objects.
@@ -123,6 +127,31 @@ def _lookup_class_or_track(class_tracker_id, class_def):
     return class_def
 
 
+def register_dynamic_module(module):
+    module_name = module.__name__ if inspect.ismodule(module) else module
+    _CUSTOM_DYNAMIC_MODULES_BY_NAME.add(module_name)
+
+
+def unregister_dynamic_module(module):
+    module_name = module.__name__ if inspect.ismodule(module) else module
+    _CUSTOM_DYNAMIC_MODULES_BY_NAME.remove(module_name)
+
+
+def _is_dynamic_module(module, submodules=True):
+    module_name = module.__name__ if inspect.ismodule(module) else module
+    if module_name in _CUSTOM_DYNAMIC_MODULES_BY_NAME:
+        return True
+    if submodules:
+        while True:
+            parent_name = module_name.rsplit(".", 1)[0]
+            if parent_name == module_name:
+                break
+            if parent_name in _CUSTOM_DYNAMIC_MODULES_BY_NAME:
+                return True
+            module_name = parent_name
+    return False
+
+
 def _whichmodule(obj, name):
     """Find the module an object belongs to.
 
@@ -205,6 +234,9 @@ def _lookup_module_and_qualname(obj, name=None):
     if module_name == "__main__":
         return None
 
+    if _is_dynamic_module(module_name):
+        return None
+
     # Note: if module_name is in sys.modules, the corresponding module is
     # assumed importable at unpickling time. See #357
     module = sys.modules.get(module_name, None)