diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index ce02e9ec1d1f..03782d03a3f8 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -391,6 +391,18 @@ jobs:
           node-version: 14.2
       - name: Test Node.js 14.2
         run: yarn test:runtime:node
+      - name: Use Node.js 16.5
+        uses: actions/setup-node@v2-beta
+        with:
+          node-version: 16.5
+      - name: Test Node.js 16.5
+        run: yarn test:runtime:node
+      - name: Use Node.js 16.6
+        uses: actions/setup-node@v2-beta
+        with:
+          node-version: 16.6
+      - name: Test Node.js 16.6
+        run: yarn test:runtime:node
 
   e2e-publish:
     name: Publish to local Verdaccio registry
diff --git a/test/runtime-integration/expected-cjs-16.0.txt b/test/runtime-integration/expected-cjs-16.0.txt
new file mode 100644
index 000000000000..7d29d238b301
--- /dev/null
+++ b/test/runtime-integration/expected-cjs-16.0.txt
@@ -0,0 +1,13 @@
+================= require - auto ====================
+typeof objectWithoutProperties: function
+typeof objectWithoutProperties.default: function
+obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
+================= require - esm =====================
+Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
+require() of ES modules is not supported.
+require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
+Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
+
+=============== require - corejs ====================
+typeof Set: function
+arr: 1,2,3
diff --git a/test/runtime-integration/expected-cjs-absolute-16.0.txt b/test/runtime-integration/expected-cjs-absolute-16.0.txt
new file mode 100644
index 000000000000..57e260d567f6
--- /dev/null
+++ b/test/runtime-integration/expected-cjs-absolute-16.0.txt
@@ -0,0 +1,13 @@
+================= require - auto ====================
+typeof objectWithoutProperties: function
+typeof objectWithoutProperties.default: function
+obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
+================= require - esm =====================
+Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
+require() of ES modules is not supported.
+require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/absolute/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
+Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
+
+=============== require - corejs ====================
+typeof Set: function
+arr: 1,2,3
diff --git a/test/runtime-integration/expected-cjs-absolute.txt b/test/runtime-integration/expected-cjs-absolute.txt
index 57e260d567f6..baf2a3a8fdfb 100644
--- a/test/runtime-integration/expected-cjs-absolute.txt
+++ b/test/runtime-integration/expected-cjs-absolute.txt
@@ -3,11 +3,8 @@ typeof objectWithoutProperties: function
 typeof objectWithoutProperties.default: function
 obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
 ================= require - esm =====================
-Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
-require() of ES modules is not supported.
-require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/absolute/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
-Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
-
+Error: require() of ES Module <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/absolute/require-esm.cjs not supported.
+Instead change the require of toPrimitive.js in <ROOT>/test/runtime-integration/src/absolute/require-esm.cjs to a dynamic import() which is available in all CommonJS modules.
 =============== require - corejs ====================
 typeof Set: function
 arr: 1,2,3
diff --git a/test/runtime-integration/expected-cjs.txt b/test/runtime-integration/expected-cjs.txt
index 7d29d238b301..0e2a3083fd52 100644
--- a/test/runtime-integration/expected-cjs.txt
+++ b/test/runtime-integration/expected-cjs.txt
@@ -3,11 +3,8 @@ typeof objectWithoutProperties: function
 typeof objectWithoutProperties.default: function
 obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
 ================= require - esm =====================
-Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
-require() of ES modules is not supported.
-require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
-Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
-
+Error: require() of ES Module <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs not supported.
+Instead change the require of toPrimitive.js in <ROOT>/test/runtime-integration/src/require-esm.cjs to a dynamic import() which is available in all CommonJS modules.
 =============== require - corejs ====================
 typeof Set: function
 arr: 1,2,3
diff --git a/test/runtime-integration/expected-esm-16.0.txt b/test/runtime-integration/expected-esm-16.0.txt
new file mode 100644
index 000000000000..dc7fd12b703c
--- /dev/null
+++ b/test/runtime-integration/expected-esm-16.0.txt
@@ -0,0 +1,22 @@
+================== import - auto ====================
+typeof inheritsLoose: function
+A.__proto__ === B true
+================= import - esm ======================
+typeof toArray: function
+arr: 1,2,3
+=============== import - corejs ====================
+typeof Set: function
+arr: 1,2,3
+================= require - auto ====================
+typeof objectWithoutProperties: function
+typeof objectWithoutProperties.default: function
+obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
+================= require - esm =====================
+Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
+require() of ES modules is not supported.
+require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
+Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
+
+=============== require - corejs ====================
+typeof Set: function
+arr: 1,2,3
diff --git a/test/runtime-integration/expected-esm.txt b/test/runtime-integration/expected-esm.txt
index dc7fd12b703c..3f911dddc92b 100644
--- a/test/runtime-integration/expected-esm.txt
+++ b/test/runtime-integration/expected-esm.txt
@@ -12,11 +12,8 @@ typeof objectWithoutProperties: function
 typeof objectWithoutProperties.default: function
 obj: { b: 2, [Symbol(Symbol.toStringTag)]: 5 }
 ================= require - esm =====================
-Error: Must use import to load ES Module: <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js
-require() of ES modules is not supported.
-require() of <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs is an ES module file as it is a .js file whose nearest parent package.json contains "type": "module" which defines all .js files in that package scope as ES modules.
-Instead rename toPrimitive.js to end in .cjs, change the requiring code to use import(), or remove "type": "module" from <ROOT>/packages/babel-runtime/helpers/esm/package.json.
-
+Error: require() of ES Module <ROOT>/packages/babel-runtime/helpers/esm/toPrimitive.js from <ROOT>/test/runtime-integration/src/require-esm.cjs not supported.
+Instead change the require of toPrimitive.js in <ROOT>/test/runtime-integration/src/require-esm.cjs to a dynamic import() which is available in all CommonJS modules.
 =============== require - corejs ====================
 typeof Set: function
 arr: 1,2,3
diff --git a/test/runtime-integration/node.cjs b/test/runtime-integration/node.cjs
index f87d44035156..527dbbd54dce 100644
--- a/test/runtime-integration/node.cjs
+++ b/test/runtime-integration/node.cjs
@@ -10,7 +10,11 @@ if (
   (major === 13 && minor >= 2)
 ) {
   const expectedEsm =
-    major === 13 && minor <= 3 ? "expected-esm-13.2.txt" : "expected-esm.txt";
+    major === 13 && minor <= 3
+      ? "expected-esm-13.2.txt"
+      : major < 16 || (major === 16 && minor <= 5)
+      ? "expected-esm-16.0.txt"
+      : "expected-esm.txt";
 
   test("ESM", "./src/main-esm.mjs", expectedEsm);
   // TODO: This never worked in any Babel version
@@ -24,6 +28,8 @@ const expectedCjs =
     ? "expected-cjs-13.0.txt"
     : major === 13 && minor <= 3
     ? "expected-cjs-13.2.txt"
+    : major < 16 || (major === 16 && minor <= 5)
+    ? "expected-cjs-16.0.txt"
     : "expected-cjs.txt";
 
 test("CJS", "./src/main-cjs.cjs", expectedCjs);
@@ -35,6 +41,8 @@ const expectedCjsAbsolute =
     ? "expected-cjs-absolute-13.0.txt"
     : major === 13 && minor <= 3
     ? "expected-cjs-absolute-13.2.txt"
+    : major < 16 || (major === 16 && minor <= 5)
+    ? "expected-cjs-absolute-16.0.txt"
     : "expected-cjs-absolute.txt";
 
 test(