diff --git a/CHANGELOG.md b/CHANGELOG.md
index a88e999bbc9..d33874d27cd 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -11,6 +11,7 @@ The version headers in this history reflect the versions of Apollo Server itself
 ## vNEXT
 
 - Add `document`, `variables`, `headers` as an option in the `ApolloServerPluginLandingPageLocalDefault` plugins. The embedded version of Apollo Sandbox can now use these options as an initial state. [PR #6628](https://github.com/apollographql/apollo-server/pull/6628)
+- Add `generateCacheKey` to `ApolloServerPluginResponseCache` to allow for custom cache keys. [PR #6655](https://github.com/apollographql/apollo-server/pull/6655)
 
 ## v3.9.0
 
diff --git a/docs/source/performance/caching.md b/docs/source/performance/caching.md
index e362c3de3f7..b6d47385acd 100644
--- a/docs/source/performance/caching.md
+++ b/docs/source/performance/caching.md
@@ -472,3 +472,4 @@ In addition to [the `sessionId` function](#identifying-users-for-private-respons
 | `extraCacheKeyData` | This function's return value (any JSON-stringifiable object) is added to the key for the cached response. For example, if your API includes translatable text, this function can return a string derived from `requestContext.request.http.headers.get('Accept-Language')`. |
 | `shouldReadFromCache` | If this function returns `false`, Apollo Server _skips_ the cache for the incoming operation, even if a valid response is available. |
 | `shouldWriteToCache` | If this function returns `false`, Apollo Server doesn't cache its response for the incoming operation, even if the response's `maxAge` is greater than `0`. |
+| `generateCacheKey` | Customize generation of the cache key. By default, this is the SHA256 hash of the JSON encoding of an object containing relevant data. |
diff --git a/packages/apollo-server-plugin-response-cache/src/ApolloServerPluginResponseCache.ts b/packages/apollo-server-plugin-response-cache/src/ApolloServerPluginResponseCache.ts
index 45009f88c65..2f5f123cf45 100644
--- a/packages/apollo-server-plugin-response-cache/src/ApolloServerPluginResponseCache.ts
+++ b/packages/apollo-server-plugin-response-cache/src/ApolloServerPluginResponseCache.ts
@@ -86,8 +86,23 @@ interface Options<TContext = Record<string, any>> {
   shouldWriteToCache?(
     requestContext: GraphQLRequestContext<TContext>,
   ): ValueOrPromise<boolean>;
+
+  // This hook allows one to replace the function that is used to create a cache
+  // key. By default, it is the SHA-256 (from the Node `crypto` package) of the result of
+  // calling `JSON.stringify(keyData)`. You can override this to customize the serialization
+  // or the hash, or to make other changes like adding a prefix to keys to allow for
+  // app-specific prefix-based cache invalidation. You may assume that `keyData` is an object
+  // and that all relevant data will be found by the kind of iteration performed by
+  // `JSON.stringify`, but you should not assume anything about the particular fields on
+  // `keyData`.
+  generateCacheKey?: GenerateCacheKeyFunction;
 }
 
+type GenerateCacheKeyFunction = (
+  requestContext: GraphQLRequestContext<Record<string, any>>,
+  keyData: unknown,
+) => string;
+
 enum SessionMode {
   NoSession,
   Private,
@@ -126,12 +141,6 @@ interface CacheValue {
   cacheTime: number; // epoch millis, used to calculate Age header
 }
 
-type CacheKey = BaseCacheKey & ContextualCacheKey;
-
-function cacheKeyString(key: CacheKey) {
-  return sha(JSON.stringify(key));
-}
-
 function isGraphQLQuery(requestContext: GraphQLRequestContext<any>) {
   return requestContext.operation?.operation === 'query';
 }
@@ -148,6 +157,9 @@ export default function plugin(
         'fqc:',
       );
 
+      const generateCacheKey: GenerateCacheKeyFunction =
+        options.generateCacheKey ?? ((_, key) => sha(JSON.stringify(key)));
+
       let sessionId: string | null = null;
       let baseCacheKey: BaseCacheKey | null = null;
       let age: number | null = null;
@@ -165,10 +177,13 @@ export default function plugin(
           async function cacheGet(
             contextualCacheKeyFields: ContextualCacheKey,
           ): Promise<GraphQLResponse | null> {
-            const key = cacheKeyString({
+            const cacheKeyData = {
               ...baseCacheKey!,
               ...contextualCacheKeyFields,
-            });
+            };
+
+            const key = generateCacheKey(requestContext, cacheKeyData);
+
             const serializedValue = await cache.get(key);
             if (serializedValue === undefined) {
               return null;
@@ -278,10 +293,13 @@ export default function plugin(
           const cacheSetInBackground = (
             contextualCacheKeyFields: ContextualCacheKey,
           ): void => {
-            const key = cacheKeyString({
+            const cacheKeyData = {
               ...baseCacheKey!,
               ...contextualCacheKeyFields,
-            });
+            };
+
+            const key = generateCacheKey(requestContext, cacheKeyData);
+
             const value: CacheValue = {
               data,
               cachePolicy: policyIfCacheable,