diff --git a/CHANGELOG b/CHANGELOG
index e28bd0e1..194309af 100644
--- a/CHANGELOG
+++ b/CHANGELOG
@@ -1,7 +1,9 @@
 Development Version
 -------------------
 
-Nothing yet.
+Bug Fixes
+
+* Fix parsing of backticks (issue588).
 
 
 Release 0.4.1 (Oct 08, 2020)
diff --git a/sqlparse/keywords.py b/sqlparse/keywords.py
index a5deb938..c967b26c 100644
--- a/sqlparse/keywords.py
+++ b/sqlparse/keywords.py
@@ -93,7 +93,7 @@ def is_keyword(value):
         (r'[0-9_A-ZÀ-Ü][_$#\w]*', is_keyword),
         (r'[;:()\[\],\.]', tokens.Punctuation),
         (r'[<>=~!]+', tokens.Operator.Comparison),
-        (r'[+/@#%^&|`?^-]+', tokens.Operator),
+        (r'[+/@#%^&|^-]+', tokens.Operator),
     ]}
 
 FLAGS = re.IGNORECASE | re.UNICODE
diff --git a/tests/test_regressions.py b/tests/test_regressions.py
index b247ce21..38d18404 100644
--- a/tests/test_regressions.py
+++ b/tests/test_regressions.py
@@ -411,3 +411,10 @@ def test_format_invalid_where_clause():
     # did raise ValueError
     formatted = sqlparse.format('where, foo', reindent=True)
     assert formatted == 'where, foo'
+
+
+def test_splitting_at_and_backticks_issue588():
+    splitted = sqlparse.split(
+        'grant foo to user1@`myhost`; grant bar to user1@`myhost`;')
+    assert len(splitted) == 2
+    assert splitted[-1] == 'grant bar to user1@`myhost`;'