diff --git a/PyInstaller/depend/utils.py b/PyInstaller/depend/utils.py
index 4776676b7f..2000b3f554 100644
--- a/PyInstaller/depend/utils.py
+++ b/PyInstaller/depend/utils.py
@@ -372,6 +372,18 @@ def load_ldconfig_cache():
     for line in text:
         # :fixme: this assumes libary names do not contain whitespace
         m = pattern.match(line)
+
+        # Sanitize away any abnormal lines of output.
+        if m is None:
+            # Warn about it then skip the rest of this iteration.
+            if re.search("Cache generated by:", line):
+                # See #5540. This particular line is harmless.
+                pass
+            else:
+                logger.warning(
+                    "Unrecognised line of output %r from ldconfig", line)
+            continue
+
         path = m.groups()[-1]
         if is_freebsd:
             # Insert `.so` at the end of the lib's basename. soname
diff --git a/news/5540.bugfix.rst b/news/5540.bugfix.rst
new file mode 100644
index 0000000000..863ddb9736
--- /dev/null
+++ b/news/5540.bugfix.rst
@@ -0,0 +1,3 @@
+Linux: Fix binary dependency scanner to support `changes to ldconfig
+<https://sourceware.org/git/?p=glibc.git;a=commitdiff;h=dfb3f101c5ef23adf60d389058a2b33e23303d04>`_
+introduced in ``glibc`` 2.33.